Oral delayed-release system for colonic specific delivery

Gazzaniga, A.; Iamartino, P.; Maffione, G.; Sangalli, M.E.

doi:10.1016/0378-5173(94)90418-9

Cited by 156 publications

(63 citation statements)

References 12 publications

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“…The negative sign in equation (1) signifies that diffusion occurs in a direction opposite to that of increasing concentration.…”

Section: Diffusion Modelsmentioning

confidence: 99%

“…While efforts have been concentrated in the past on absorption of drugs from the stomach, duodenum and the upper part of the small intestine (in the case of enteric coated drugs), only recently has it emerged that specific sites exist in the distal parts of the small intestine and the colon where large drug molecules can be absorbed into systemic circulation if only they can get there. 1 Of particular interest in this regard are proteins and peptides. This group of drugs is usually administered parenterally.…”

Section: Introduction Drug Absorption Via the Oral Routementioning

confidence: 99%

See 1 more Smart Citation

An overview of site-specific delivery of orally administered proteins/peptides and modelling considerations

Arhewoh¹,

Okhamafe²

2009

Journal of Medicine and Biomedical Research

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“…The negative sign in equation (1) signifies that diffusion occurs in a direction opposite to that of increasing concentration.…”

Section: Diffusion Modelsmentioning

confidence: 99%

Section: Introduction Drug Absorption Via the Oral Routementioning

confidence: 99%

An overview of site-specific delivery of orally administered proteins/peptides and modelling considerations

Arhewoh¹,

Okhamafe²

2009

Journal of Medicine and Biomedical Research

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“…In pressure-controlled ethylcellulose singleunit capsules the drug is in a liquid. Lag times of three to five hours in relation to drug absorption were noted when pressure-controlled capsules were administered to human [26].…”

Section: Rubin Et Al 1992mentioning

confidence: 99%

Primary and novel approaches for colon targeted drug delivery – A review

Tiwari¹,

Tiwari²,

Wal³

et al. 2010

Int. J. Drug Delivery

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The colon is a site where both local and systemic delivery of drugs can take place. Local delivery could, for example, allow topical treatment of inflammatory bowel disease. Treatment could be made more effective if it were possible for drugs to be targeted directly on the colon. Systemic side effects could also be reduced. Colon specific systems might also allow oral administration of peptide and protein drugs, which are normally inactivated in the upper parts of the gastrointestinal tract. Primary approaches for CDDS (Colon Specific Drug Delivery), which includes prodrugs, pH and time dependent systems and microbially triggered drug delivery system achieved limited success and having limitations. Newly developed CDDS, which includes pressure controlled colonic delivery capsules (PCDCS), CODES TM and osmotic controlled drug delivery are unique in terms of achieving in vivo site specificity and feasibility of manufacturing process. This review also focuses on evaluations of CDDS in general.

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“…The time lag depends on the thickness of the coating layer [46]. The Time Clock® system consists of a solid dosage form coated with lipid barriers containing carnauba wax and bees wax along with surfactants, such as polyoxyethylene sorbitan monooleate [47,48]. This coat erodes or emulsifies in the aqueous environment in a time proportional to the thickness of the film, and the core is then available for dispersion.…”

Section: Iiport Systemsmentioning

confidence: 99%

Recent trends in pulsatile drug delivery systems - A review.

Sharma¹,

Srikanth²,

Uhumwangho³

et al. 2010

Int j Drug delivery

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The purpose of writing this review on pulsatile drug delivery systems (PDDS) is to compile the recent literatures with special focus on the different types and approaches involved in the development of the formulation. PDDS are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site. Some of the disease conditions wherein PDDS are promising include duodenal ulcer, cardiovascular diseases, arthritis, asthma, diabetes, neurological disorder, cancer, hypertension and hypercholesterolemia. PDDS can be classified into time controlled systems wherein the drug release is controlled primarily by the delivery system, stimuli induced PDDS in which release is controlled by the stimuli, such as the pH or enzymes present in the intestinal tract or enzymes present in the drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation. This review also summarizes some current PDDS already available in the market. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.

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Oral delayed-release system for colonic specific delivery

Cited by 156 publications

References 12 publications

An overview of site-specific delivery of orally administered proteins/peptides and modelling considerations

An overview of site-specific delivery of orally administered proteins/peptides and modelling considerations

Primary and novel approaches for colon targeted drug delivery – A review

Recent trends in pulsatile drug delivery systems - A review.

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