Oral delivery of curcumin bound to chitosan nanoparticles cured Plasmodium yoelii infected mice

Akhtar, Feroz; Rizvi, Abbas; Kar, Sasmita

doi:10.1016/j.biotechadv.2011.05.009

Cited by 187 publications

(97 citation statements)

References 37 publications

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“…Their nanoparticles size was 100 ± 20 nm with spherical shape (27). Akhtar et.al also produced curcumin-loaded chitosan nanoparticles with size of more than 200 nm while curcumin-loaded chitosan nanoparticles with size of 160 nm were made in our research (30). Here, surface charge of the produced curcumin-loaded chitosan nanoparticles was +7 ± 2 mV whereas the surface charge of chitosan-TPP nanoparticles alone has been reported +25 ± 4 mV.…”

Section: Discussionmentioning

confidence: 46%

Curcumin-loaded Chitosan Tripolyphosphate Nanoparticles as a safe,natural and effective antibiotic inhibits the infection of Staphylococcusaureus and Pseudomonas aeruginosa in vivo

Jahromi¹,

Al-Musawi²,

Pirestani³

et al. 2014

Iran J Biotech

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Section: Discussionmentioning

confidence: 46%

Curcumin-loaded Chitosan Tripolyphosphate Nanoparticles as a safe,natural and effective antibiotic inhibits the infection of Staphylococcusaureus and Pseudomonas aeruginosa in vivo

Jahromi¹,

Al-Musawi²,

Pirestani³

et al. 2014

Iran J Biotech

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“…3 The poor solubility of curcumin limits its absorption and results in low bioavailability. 4 Many new drug delivery systems have been developed to increase the aqueous solubility and the bioavailability of curcumin by using a variety of drug carriers, including liposomes, 5 phospholipid, 6 cyclodextrin, 7 chitosan nanoparticles, 8 protein nanoparticles such as silk fibroin, 9 zein, 10 and bovine serum albumin, 11 synthetic polymer nanoparticles such as PLGA, 12,13 PCL-PEG-PCL triblock copolymer, 14 and polymer nanofibers such as polyvinyl alcohol (PVA), 15 poly-(ε-caprolactone), 16 and zein. 17 Another approach for improving the bioavailability of poorly water-soluble drugs is the micronization of these drugs.…”

Section: Introductionmentioning

confidence: 99%

Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

Zhao¹,

Xie²,

Li³

et al. 2015

IJN

138

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In order to enhance the bioavailability of poorly water-soluble curcumin, solution-enhanced dispersion by supercritical carbon dioxide (CO 2 ) (SEDS) was employed to prepare curcumin nanoparticles for the first time. A 2 4 full factorial experiment was designed to determine optimal processing parameters and their influence on the size of the curcumin nanoparticles. Particle size was demonstrated to increase with increased temperature or flow rate of the solution, or with decreased precipitation pressure, under processing conditions with different parameters considered. The single effect of the concentration of the solution on particle size was not significant. Curcumin nanoparticles with a spherical shape and the smallest mean particle size of 325 nm were obtained when the following optimal processing conditions were adopted: P =20 MPa, T =35°C, flow rate of solution =0.5 mL·min −1 , concentration of solution =0.5%. Fourier transform infrared (FTIR) spectroscopy measurement revealed that the chemical composition of curcumin basically remained unchanged. Nevertheless, X-ray powder diffraction (XRPD) and thermal analysis indicated that the crystalline state of the original curcumin decreased after the SEDS process. The solubility and dissolution rate of the curcumin nanoparticles were found to be higher than that of the original curcumin powder (approximately 1.4 μg/mL vs 0.2 μg/mL in 180 minutes). This study revealed that supercritical CO 2 technologies had a great potential in fabricating nanoparticles and improving the bioavailability of poorly water-soluble drugs.

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“…[33][34][35][36] Some reports on CS-CN-NPs revealed enhanced bioavailability of anticancer and antimalarial drugs in comparison with pure CN but did not show the effect of acidic pH on release of NPs. [37][38][39] In this study, the coating of chitosan nanoparticles with pH sensitive Eudragit polymer was exhaustively studied to overcome the effect of highly acidic environment.…”

mentioning

confidence: 99%

Biodistribution and targeting potential assessment of mucoadhesive chitosan nanoparticles designed for ulcerative colitis via scintigraphy

Raj

Kaul

et al. 2018

RSC Adv.

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aIn the present investigation we have prepared and characterized curcumin (CN)-containing chitosan nanoparticles (CS-NPs) coated with Eudragit FS 30D for colon-specific drug delivery for treatment of ulcerative colitis. Methods: CS-NPs were prepared by ionic gelation using tripolyphosphate. To specify pH sensitive delivery, CS-CN-NPs were coated with Eudragit FS 30D by using a solvent evaporation method. Different process parameters were evaluated, and the optimized formulation was characterized by particle size, size distribution, zeta potential and encapsulation efficiency before lyophilization. The lyophilized product was further subjected to Fourier-transform infrared spectroscopy, and particle morphology and in vitro drug release in different media were studied. Results: the kinetics of in vitro drug release from the CS-CN-NPs revealed sustained release behaviour of the developed carriers. In vivo biodistribution study by gamma-scintigraphy showed good accumulation of the developed nanocarriers in the colonic region. Conclusion: sustained and pH stimulated delivery of CN to the colon was successfully attained via coating of CS-NPs with Eudragit FS 30D to circumvent poor absorption and availability of CN.

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Oral delivery of curcumin bound to chitosan nanoparticles cured Plasmodium yoelii infected mice

Cited by 187 publications

References 37 publications

Curcumin-loaded Chitosan Tripolyphosphate Nanoparticles as a safe,natural and effective antibiotic inhibits the infection of Staphylococcusaureus and Pseudomonas aeruginosa in vivo

Curcumin-loaded Chitosan Tripolyphosphate Nanoparticles as a safe,natural and effective antibiotic inhibits the infection of Staphylococcusaureus and Pseudomonas aeruginosa in vivo

Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

Biodistribution and targeting potential assessment of mucoadhesive chitosan nanoparticles designed for ulcerative colitis via scintigraphy

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