Oral drug absorption enhancement by chitosan and its derivatives

Thanou, Maya; Verhoef, J.; Junginger, Hans E.

doi:10.1016/s0169-409x(01)00231-9

Cited by 618 publications

(336 citation statements)

References 47 publications

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“…In addition, its mucoadhesive property [10] is another advantage for promoting drug adsorption due to combination with anionic substructures such as sialic acid moieties of the mucosa layer. The adhesion of chitosan at the site of drug absorption offers various advantages for an improved uptake of therapeutic peptides [11,12].…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of new insulin containing polysaccharide nanoparticles

Sarmento

Ribeiro

Veiga

et al. 2006

Colloids and Surfaces B: Biointerfaces

230

140

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A nanoparticle insulin delivery system was prepared by complexation of dextran sulfate and chitosan in aqueous solution. Parameters of the formulation such as the final mass of polysaccharides, the mass ratio of the two polysaccharides, pH of polysaccharides solution, and insulin theorical loading were identified as the modulating factors of nanoparticle physical properties. Particles with a mean diameter of 500 nm and a zeta potential of approximately −15 mV were produced under optimal conditions of DS:chitosan mass ratio of 1.5:1 at pH 4.8. Nanoparticles showed spherical shape, uniform size and good shelf-life stability. Polysaccharides complexation was confirmed by differential scanning calorimetry and Fourier transformed infra-red spectroscopy. An association efficiency of 85% was obtained. Insulin release at pH below 5.2 was almost prevented up to 24 h and at pH 6.8 the release was characterized by a controlled profile. This suggests that release of insulin is ruled by a dissociation mechanism and DS/chitosan nanoparticles are pH-sensitive delivery systems. Furthermore, the released insulin entirely maintained its immunogenic bioactivity evaluated by ELISA, confirming that this new formulation shows promising properties towards the development of an oral delivery system for insulin.

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Section: Introductionmentioning

confidence: 99%

Development and characterization of new insulin containing polysaccharide nanoparticles

Sarmento

Ribeiro

Veiga

et al. 2006

Colloids and Surfaces B: Biointerfaces

230

140

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show abstract

“…However, poor hydrophilicity limit the utility of PLLA [25]. Chitosan grafting is a common way to improve the properties of material such as bacteriostatic effect [26], enhancing adsorption properties [27], and improving biocompatibility [28]. In our research, chitosan helped to promote hydrophilicity of the PLLA membrane.…”

Section: Characterization Of Plla-cs Membranementioning

confidence: 80%

Biodegradable electrospun PLLA/chitosan membrane as guided tissue regeneration membrane for treating periodontitis

et al. 2013

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This paper explores the application potential of a biodegradable PLLA/chitosan electrospun composite membrane for guided periodontal tissue regeneration which in addition serves as a fibroblast barrier. Electrospinning was applied to fabricate the PLLA membrane and aminolysis method was applied to graft chitosan on its surface. The morphology of the PLLA/chitosan membrane was observed by SEM. The surface chemical composition was analyzed by XPS. The appearance of N 1s peak in XPS demonstrated the successful grafting of chitosan on the PLLA electrospin membrane. After the modification, the water contact angle decreased from 136.9 ± 2.18°to 117.0 ± 2.10°, representing an improved hydrophilicity of the membrane. The bioactivity of the membrane was analyzed by XPS after soaking in SBF. The deposits had a Ca/P ratio of 1.6, indicating the hydroxyapatite formation on PLLA/chitosan membrane. The degradation rate was determined by measuring mass loss after immersion in PBS at different time periods. Compared to pure PLLA electrospun membrane which was almost nondegradable, the degradation rate of PLLA/chitosan composite membrane was up to 20 % in 6 weeks while maintaining its basic architecture to keep supporting the regenerated tissue. Live-dead cell staining of MC3T3 E1 cells cultured on the surface of the membrane showed a good biocompatibility of the PLLA/chitosan membrane. Furthermore, fibroblast cell line NIH 3T3 was cultured on surface of the membrane for the evaluation of cell penetration. The result demonstrated that the membrane worked as a fibroblast barrier to minimize the unfavorable effect of fibroblasts on periodontal tissue regeneration. Therefore, this electrospun PLLA/chitosan composite membrane has more potential for clinical application compared to old generation regeneration membrane with both suitable degradation rate and non-fibroblast penetration property.

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“…Many researches have been done to find the toxicity of chitosan [9,23,24] . Chitosan is widely regarded as a non-toxic, biologically compatible polymer [25] . It is approved for dietary applications in Japan, Italy and Finland [26] .…”

Section: Discussionmentioning

confidence: 99%

In vitro treatments of Echinococcus granulosus with fungal chitosan, as a novel biomolecule

Esboei

Fakhar

Chabra

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Oral drug absorption enhancement by chitosan and its derivatives

Cited by 618 publications

References 47 publications

Development and characterization of new insulin containing polysaccharide nanoparticles

Development and characterization of new insulin containing polysaccharide nanoparticles

Biodegradable electrospun PLLA/chitosan membrane as guided tissue regeneration membrane for treating periodontitis

In vitro treatments of Echinococcus granulosus with fungal chitosan, as a novel biomolecule

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