Oral erosive lichen planus associated with thymoma treated with etretinate

Miyagaki, Tomomitsu; Sugaya, Makoto; Miyamoto, Akihito; Nagata, Mayumi; Ichimura, Yohei; Mitsui, Hiroshi; Sato, Shinichi

doi:10.1111/j.1440-0960.2011.00818.x

Cited by 11 publications

(8 citation statements)

References 12 publications

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“…Three LP patients accompanied by thymoma are summarized in Table . In addition, we summarize 29 LP patients accompanied by thymoma previously reported in the English‐language published works (Table ) . The mean age of patients was 56.2 ± 11 years, and the male : female ratio was 1:1.…”

Section: Discussionmentioning

confidence: 95%

Lichen planus complicated with thymoma: Report of three Japanese cases and review of the published work

Motegi

Uchiyama

Yamada

et al. 2015

The Journal of Dermatology

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Thymoma is recognized to be complicated with autoimmune diseases, such as myasthenia gravis, pemphigus vulgaris and bullous pemphigoid. Abnormal regulation of autoreactive lymphocytes may be involved in the pathogenesis of the autoimmune diseases. The association of thymoma and lichen planus (LP) is relatively rare. Among 50 patients with LP, we identified three patients with LP accompanied by thymoma (6%; 3/50) in our department from 2004 to 2014. This is the first report identifying the frequency of thymoma accompanied by LP among patients with LP. We herein report three cases of LP accompanied by thymoma along with clinical and histological features. In addition, we summarize 29 LP patients accompanied by thymoma previously reported in the English-language published works. Regarding the complications, hypogammaglobulinemia accompanied 58.6% (17/29) of patients diagnosed with Good's syndrome. Alopecia was present in 13.8% (4/29) of patients, and myasthenia gravis was present in 17.2% (5/29) of patients with LP and thymoma. Among the 27 patients with thymectomy, only 25.9% (7/27) experienced the improvement of LP, suggesting that thymectomy may not be effective for the lesions of LP. Treatment-resistant LP was reported in 54.2% (13/24) of patients. In all our cases, oral lesions were intractable to treatment with oral predonisone and topical steroids and/or tacrolimus. It is important for dermatologists to recognize the clinical characteristics of the patients with both LP and thymoma.

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Section: Discussionmentioning

confidence: 95%

Lichen planus complicated with thymoma: Report of three Japanese cases and review of the published work

Motegi

Uchiyama

Yamada

et al. 2015

The Journal of Dermatology

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“…Le diagnostic du syndrome APECED a été confirmé dans le cas décrit par la mutation du gène AIRE qui a été recherché devant les signes cliniques évocateurs du syndrome, notamment une candidose chronique cutanéo-muqueuse. En revanche, l'apparition de lésion de lichen plan buccal connue dans les post-thymectomies [11,12] n'est pas associée au syndrome APECED.…”

Section: Discussionunclassified

Syndrome APECED et lichen plan atrophique : un cas

Regnault

Catros

Sibaud

et al. 2016

Med Buccale Chir Buccale

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-Introduction:Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an autosomal recessive disease defined by two of the following conditions: hypoparathyroidism, adrenocortical failure and chronic mucocutaneous candidiasis. Other autoimmune disorders may be associated with it. Chronic candidiasis is usually the first and most common aspect of the syndrome. Case report: We report the case of a 19-year-old man whose clinical manifestations of APECED comprised adrenocortical failure, keratopathy and alopecia. Chronic candidiasis was previously clinically suspected, but never demonstrated with mucocutaneous scraping and cultures. APECED status was confirmed after identification of a mutation in the AIRE gene. In the oral mucosa, atrophic and erosive lesions were observed, which were compatible with oral lichen planus. This was histologically confirmed. Discussion: The finding of oral lichen planus in an APECED patient is unusual, and it poses the question of the occurrence of misdiagnosis of candidiasis in some cases of APECED, which could be due to the lack of histological examinations of these lesions. Conclusion: Dentists should be aware of this dystrophy, as oral manifestations are not specific but can be related to more common oral diseases such as oral lichen planus or candidiasis.

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“…The incidence of thymoma is rare, but it can present as a benign lesion or a highly infiltrative and even a metastasizing tumor [9]. Complete resection is crucial for stage III thymoma, despite the involvement of adjacent structures, and only 60% have a complete resection.…”

Section: Discussionmentioning

confidence: 99%

Postoperative radiotherapy for completely resected Masaoka stage III thymoma: a retrospective study of 65 cases from a single institution

et al. 2013

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BackgroundThe role of adjuvant radiotherapy (RT) for patients with stage III thymoma after complete resection is not definite. Some authors have advocated postoperative RT after complete tumor resection, but some others suggested observation. In this study, we retrospectively evaluated the effect of postoperative RT on survival as well as tumor control in patients with Masaoka stage III thymoma.MethodsBetween June 1982 and December 2010, 65 patients who underwent complete resection of stage III thymoma entered the study. Fifty-three patients had adjuvant RT after surgery (S + R) and 12 had surgery only (S alone). Of patients who had adjuvant RT, 28 had three-dimensional conformal RT (3D-CRT)/intensity modulated RT (IMRT) and 25 had conventional RT. A median prescribed dose of 56 Gy (range, 28–60 Gy) was given.ResultsThe median follow-up time was 50 months (range, 5–360 months). Five- and 10-year overall survival (OS) rates were 91.7% and 71.6%, respectively, for S + R and 81.5% and 65.2% for S alone (P = 0.5), respectively. In the subgroup analysis, patients with 3D-CRT/IMRT showed a trend of improved 5-year OS rate compared with conventional RT (100% vs. 86.9%, P =0.12). Compared with S alone, the 5-year OS rate was significantly improved (100% vs. 81.5%, P = 0.049). Relapses occurred in 15 patients (23.1%). There was a trend of lower crude local recurrence rates for S + R (3.8%) compared with S alone (16.7%) (P = 0.09), whereas the crude regional recurrence rates were similar (P = 0.9). No clear dose–response relationship was found according to prescribed doses.ConclusionsAdjuvant 3D-CRT/IMRT showed potential advantages in improving survival and reducing relapse in patients with stage III thymoma after complete resection, whereas adjuvant RT did not significantly improve survival or reduce recurrence for the cohort as a whole. Doses of ≤ 50 Gy may be effective and could be prescribed for adjuvant RT. To confirm the role of adjuvant 3D-CRT/IMRT in patients who undergo a complete resection of thymoma, a multicenter randomized study should be performed.

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Oral erosive lichen planus associated with thymoma treated with etretinate

Cited by 11 publications

References 12 publications

Lichen planus complicated with thymoma: Report of three Japanese cases and review of the published work

Lichen planus complicated with thymoma: Report of three Japanese cases and review of the published work

Syndrome APECED et lichen plan atrophique : un cas

Postoperative radiotherapy for completely resected Masaoka stage III thymoma: a retrospective study of 65 cases from a single institution

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