Oral florid papillomatosis: Topical treatment with 5% imiquimod in orabase

Ruiz-Huertas, Pedro; Borrego-Luque, Alicia; Toledano-Valero, Pilar; Manzotti, Carolina; Mayordomo, Ángel Rollón

doi:10.1002/cre2.557

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…Indeed, as reported in a recent clinical study, HA accelerates the re-epithelization process in human skin wounds compared to pre-treatments with saline solution [ 91 ]. Moreover, in the case of florid oral papillomatosis, the treatment with HA gel helps to regenerate the perilesional mucosa, thus preventing the occurrence of side effects and reducing the need for additional surgical intervention, with the consequent improvement in patients’ quality of life [ 92 ].…”

Section: Hyaluronic Acidmentioning

confidence: 99%

Preventing Persistence of HPV Infection with Natural Molecules

et al. 2023

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Human papillomavirus (HPV) infection is one the most common sexually transmitted infections worldwide. In most cases, the infection is temporary and asymptomatic; however, when persistent, it may lead to lesions that can evolve into cancer in both women and men. Nowadays, prophylactic vaccination is the primary preventive strategy for HPV infections, but vaccines do not cover all types of HPV strains. Scientific research has uncovered the beneficial role of some natural supplements in preventing persistent HPV infections or treating HPV-related lesions. We review the current insight into the roles of natural molecules in HPV infection with a special focus on epigallocatechin gallate (EGCG), folic acid, vitamin B12, and hyaluronic acid (HA). Specifically, EGCG from green tea extracts plays a critical role in suppressing HPV oncogenes and oncoproteins (E6/E7), which are responsible for HPV oncogenic activity and cancer development. Folic acid and vitamin B12 are essential vitamins for multiple functions in the body, and accumulating evidence suggests their importance in maintaining a high degree of methylation of the HPV genome, thus decreasing the likelihood of causing malignant lesions. HA, due to its re-epithelizing property, may prevent HPV virus entry in damaged mucosa and epithelia. Thereby, based on these premises, the combination of EGCG, folic acid, vitamin B12, and HA may be a very promising therapeutic approach to prevent HPV persistence.

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Section: Hyaluronic Acidmentioning

confidence: 99%

Preventing Persistence of HPV Infection with Natural Molecules

et al. 2023

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“…• Multiple verruciform and papillomatous growths that converge forming plaques and vegetations • Considered as a variant of low degree of malignancy of oral mucosal verrucous carcinoma 10 Chemical Chemical burns • Caused by topical applications of medications/therapeutics (aspirin, adalimumab, dental products, etc) and various foods (notably garlic). • A grayish-white fibrin-coated ulcer at the site of application associated with burning sensation/pain.…”

Section: Leukoplakiamentioning

confidence: 99%

White sponge nevus of the oral cavity: Affecting members of two generations in a family

Gupta

Lamichhane

Redhu

2023

Clinical Case Reports

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The typical feature is the autosomal dominant heritance and clinically dormant, non-scarpalble, white diffuse, soft, thickened white plaques with a corrugated surface affecting mostly the buccal mucosa bilaterally which can substantially lead to the diagnosis of white sponge nevus. K E Y W O R D Sautosomal dominant, Cannon's disease, oral mucosa, white lesion, white sponge nevus How to cite this article: Gupta A, Lamichhane RS, Redhu A. White sponge nevus of the oral cavity: Affecting members of two generations in a family.

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Oral florid papillomatosis: Topical treatment with 5% imiquimod in orabase

Ruiz-Huertas

Borrego-Luque

Toledano-Valero

et al. 2022

Clinical & Exp Dental Res

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Background Florid oral papillomatosis is characterized by its tendency to local recurrence that requires multiple treatments, leading to important functional sequelae. Methods We present 74‐year‐old woman with oral florid papillomatosis (OFP) who refused a new surgical treatment, and was treated with imiquimod 5% in orabase on alternate days for 16 weeks. Treatment was complemented with application of hyaluronic acid gel. Results There were no side effects to the treatment, nor signs of local recurrence, in the treated area at 2 years of follow‐up. Conclusions After reviewing the literature and according to our knowledge, this is the first published case of oral florid papillomatosis treated topically with imiquimod 5% successfully. Topical treatment with imiquimod 5% in orabase may be a valid alternative for patients with recurrent OFP located in the anterior area of the oral cavity who refuse surgical treatment, although we must closely monitor the patient for the possibility of recurrence or malignant degeneration.

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Oral florid papillomatosis: Topical treatment with 5% imiquimod in orabase

Cited by 7 publications

References 21 publications

Preventing Persistence of HPV Infection with Natural Molecules

Preventing Persistence of HPV Infection with Natural Molecules

White sponge nevus of the oral cavity: Affecting members of two generations in a family

Oral florid papillomatosis: Topical treatment with 5% imiquimod in orabase

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