Oral focal mucinosis: report of 15 cases and review of the literature

Aldred, Michael J.; Talacko, Anna; Ruljancich, Kevin; Story, Rowan D.; Newland, Stuart; Chen, Stephen T.; O'Grady, John F.; Bergman, John D.; Smith, A. Gordon; Dimitroulis, George; Redman, John F.; Sheldon, William R.; Mansour, Alan K.; Watkins, Don; Radden, B. G.

doi:10.1080/00313020310001602639

Cited by 48 publications

(57 citation statements)

References 8 publications

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“…In this respect, the rarity must also be emphasised of the oral lesions of mixomatous nature (6). Such lesions include, besides the described case, soft tissue myxoma, nerve sheath myxomas, odontogenic myxoma, myxomatous changes in fibrous lesions, neurofibroma with myxomatous transformation, oral mucous escape reaction or mucocele, and the ectomesenchymal chondromyxoid tumor of the anterior tongue (6,8,9,(13)(14)(15).…”

Section: Discussionmentioning

confidence: 88%

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Oral Focal Mucinosis of the Tongue: A Rare Clinical Case

et al. 2012

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Oral focal mucinosis (OFM) is a rare mucosal lesion of unknown etiopathogenesis. It is considered the oral counterpart of cutaneous focal mucinosis. From the anatomo-pathological point of view it is characterised by a focal degeneration of myxoid type of connective tissue. A literature survey revealed 50 reports of OFM cases worldwide. Here, we present an even more rare case with tongue involvement. Particular emphasis is placed on diagnostic-differential aspects of this kind of lesion, both from the clinical and the histopathological point of view, in respect to other manifestations of tongue mucosa.

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Section: Discussionmentioning

confidence: 88%

“…Excluding this one with tongue localization, 52 cases ofOFM have been documented worldwide since the original study of Tomich (4)(5)(6). Only three other cases of tongue OFM have been previously recorded (3,(7)(8)(9)(10).…”

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confidence: 99%

Oral Focal Mucinosis of the Tongue: A Rare Clinical Case

et al. 2012

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“…As the differential diagnosis also includes myxoid neural lesions, S100 staining is important in establishing the diagnosis, with cases of OFM being negative (1) . In our case, negativity for S100 was observed in the mucinous area, what reinforced the diagnosis of OFM.…”

Section: Discussionmentioning

confidence: 99%

“…The myxomatosis/mucinosis area is a loose connective tissue composed by an accumulation of hyaluronic acid and collagen fibrils that are widely separated and interspersed with stellate-shaped fibroblasts, with or without inflammation, and covered with stratified squamous epithelium (1,2,5,7) . All the histological features were observed in the present case.…”

Section: Discussionmentioning

confidence: 99%

Large oral focal mucinosis: a case report

Silva

Monteiro

Norões

et al. 2014

J. Bras. Patol. Med. Lab.

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The aim of this article is to report the case of a 23-year-old female patient that sought dental service for examination of an asymptomatic slow-growing large lump in the mandibular gingiva causing displacement of the right first molar. Excisional biopsy, histopathological analysis, Alcian blue/periodic acid-Schiff (PAS) staining and immunohistochemistry analysis for S-100 were performed. The diagnosis established was oral focal mucinosis. After three years, the patient is still under follow-up, without any recurrences. Although cases of oral focal mucinosis of this particular size are rare, this entity should be considered in the differential diagnosis of oral lesions located in the gingiva.

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“…Therefore, they are often diagnosed as gingival hyperplasia, fibroma, pyogenic granuloma or fibrous epulis. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Histopathology of OFM shows a focal myxoid degeneration of the connective tissue, possibly due to the over production of hyaluronic acid by fibroblasts during collagen production, and is the definitive diagnosis for OFM. 2 In the current case report, OFM occurred after a routine crown lengthening procedure with clinical presentation resembling that of Desquamative Gingivitis (DG).…”

Section: -17mentioning

confidence: 99%

A Rare Oral Focal Mucinosis Presentation in the Aesthetic Zone: A Case Report

Tiwana¹,

Janic²,

Wheater³

et al. 2016

Dent Open J

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The current case report presents a rare oral pathology of Oral Focal Mucinosis (OFM). The patient developed marginal gingival inflammation subsequent to esthetic crown lengthening surgery. The differential diagnosis included candidal infection, foreign body gingivitis, and Desquamative Gingivitis (DG). An incisional biopsy was performed, indicating a definitive histopathological diagnosis of OFM. OFM is a lesion developing due to over production of hyaluronic acid by fibroblasts, compromising the normal collagen production. Treatment of OFM is excisional biopsy, however; its location near the gingival margin in the aesthetic zone required a minimally invasive surgical approach. Therefore, a less invasive treatment using corticosteroids was administered, leading to resolution of the inflammation.

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Oral focal mucinosis: report of 15 cases and review of the literature

Cited by 48 publications

References 8 publications

Oral Focal Mucinosis of the Tongue: A Rare Clinical Case

Oral Focal Mucinosis of the Tongue: A Rare Clinical Case

Large oral focal mucinosis: a case report

A Rare Oral Focal Mucinosis Presentation in the Aesthetic Zone: A Case Report

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