Oral Intake of the Commercial Probiotic Blend Synbio® for the Management of Vaginal Dysbiosis

Abstract

A healthy vaginal microbiota is Lactobacillus-dominated. Several factors can interfere with the state of balance leading to dysbiosis, such as vaginal infections caused by bacteria and Candida species. The present single-arm, uncontrolled open-label study aimed to evaluate the ability of the SYNBIO® probiotic combination, taken as an oral formulation, to contribute to vaginal health. Thirty pre-menopausal participants were included in the study. Participants were instructed for daily oral intake of SYNBIO® probiotic capsules for 15 days. Vaginal swabs were collected at baseline (T0), 15 days after the start of the treatment (T1), and 7 days after the end of the treatment (T2). Amsel criteria, Nugent score, and vaginal pH were evaluated at each sampling time. In addition, the participants’ quality of life was assessed by the WHOQOL-BREF questionnaire. The administration of SYNBIO® once daily for 15 days resulted in a substantial improvement in the vaginal flora in terms of an increase in lactobacilli and a decrease in enterococci, staphylococci, Gardnerella spp., and Candida spp. According to the results, statistically significant changes in leucorrhoea, itching, and vulvo-vaginal erythema/edema as well as a decrease in all the Amsel criteria were recorded. The oral consumption of SYNBIO® demonstrated enhanced benefits for vaginal health.

Lactobacillus Probiotics Improve Vaginal Dysbiosis in Asymptomatic Women

“…L. acidophilus, L. rhamnosus, and L. reuteri are used as raw materials in healthy functional foods (daily intake of 10 8 -10 10 CFU) according to Health Functional Food Standards, Ministry of Food and Drug Safety. In another study, administering a 1:1 combination of L. rhamnosus IMC 501 ® and Lactobacillus paracasei IMC 502 ® (5 × 10 9 CFU/capsule/day for 15 consecutive days) improved leucorrhea, itching, and vulvo-vaginal erythema/edema [29]. In the present study, L. acidophilus, L. rhamnosus and L. reuteri abundance showed a decrease at visit 2 (Figure 6).…”

“…Specific probiotics, such as Lactobacillus probiotics (LBPs), are suggested to have safe and promising therapeutic effects to modulate microbiota homeostasis in the general population [27]. Studies have shown that oral LBP intake not only improves vaginal microbiota dysbiosis significantly, but also improves leucorrhea, itching, and vulvo-vaginal erythema/edema [28,29]. In addition, Lactobacillus surface active molecules (peptidoglycan, lipoteichoic acid, exopolysaccharides, etc.)…”

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

“…Participants taking daily oral probiotic lactobacilli capsules can lead to a substantial improvement in the vaginal flora in terms of an increase in lactobacilli and a decrease in enterococci, staphylococci, Gardnerella spp., and Candida spp. in mixed vaginal infected patients ( Pino et al., 2022b ; Rapisarda et al., 2023 ).…”