Oral Leukoplakia – Is Biopsy at the Initial Appointment a Must?

Mutalik, Sunil; Mutalik, Vimi Sunil; Pai, Keerthilatha M.; Naikmasur, Venkatesh G; Phaik, Khoo Suan

doi:10.7860/jcdr/2014/8717.4659

Cited by 3 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, a similar frequency was reported for lip and floor of the mouth, while no case of tongue OSCC originating from a white lesion was reported. A recent study reported that different clinical types of leukoplakia were clinically misdiagnosed in 16,52% of cases, while malignancies were detected in 6,96% of cases when it was not initially suspected [15]. In the current study, the frequency of OSCC in leukoplakia was found to be even greater (11.11%), while the frequency of OSCC in the total number of white lesions subjected to histopathology was 2.84%.…”

Section: Discussionsupporting

confidence: 39%

Oral epithelial dysplasia and oral cancer prevalence in routine white lesion biopsies – a 6-year retrospective study

Kuzio

Wapniarska

Danilewicz

et al. 2020

J Pre Clin Clin Res.

View full text Add to dashboard Cite

Introduction. Leukoplakia and oral lichen planus (OLP) are common diseases manifesting as white lesions that are considered potentially malignant disorders (PMD). Epithelial dysplasia may be an early sign of potency for the future transformation into oral squamous cell carcinoma (OSCC). A routine biopsy and close observation are recommended for persistent white oral lesions. As frictional keratosis may mimic oral leukoplakia, the question arises:Is there a need for a biopsy of persistent white lesion of traumatic origin? Materials and methods. Data from 643 oral tissue biopsies were retrospectively analyzed. A total of 176 (27.37%) results with provisional diagnosis of leukoplakia (36 cases), OLP (77 cases) and frictional keratosis (63 cases) were selected. Retrospective data collected included age, gender, smoking status, provisional and histopathological diagnosis. The data was analyzed to assess the prevalence of epithelial dysplasia and OSCC in terms of age, gender and smoking status. Results. Five (2.84%) cases of OSSC were reported, all of them were graded as G1; four cases of OSCC were found in clinically defined leukoplakia lesions; one case of OSCC (1.3%) was found in OLP biopsy; epithelial dysplasia was reported in 5 lesions (2.84%) provisionally diagnosed as OLP (3 cases), and leukoplakia in 2 cases. No dysplasia or OSCC were found in the lesions diagnosed as frictional keratosis. Conclusions. Epithelial dysplasia and OSCC may be found in leukoplakia or OLP lesions not initially suspected of any malignancy. In some cases, clinical features are not sufficient to diagnose a lesion without histopathology. Frictional keratosis is easily identified by clinicians, and may not require a biopsy in every case. Clinical and histopathological evaluation of the white lesions still needs improvement.

show abstract

Section: Discussionsupporting

confidence: 39%

Oral epithelial dysplasia and oral cancer prevalence in routine white lesion biopsies – a 6-year retrospective study

Kuzio

Wapniarska

Danilewicz

et al. 2020

J Pre Clin Clin Res.

View full text Add to dashboard Cite

show abstract

“…There are multiple genetic mutations that must occur for normal tissues to progress to dysplasia or squamous cell carcinoma. Biopsy remains the gold standard for the investigating for Oral epithelial dysplasia and oral squamous cell carcinoma (Mutalik et al, 2014;Boeve et al, 2018). Two common conditions of precancerous lesions were included in the current study; leukoplakia and erythroplakia.…”

Section: Introductionmentioning

confidence: 99%

Ki-67 Prognostic Value in Different Histological Grades of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Takkem

Barakat

Zakaraia

et al. 2018

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Introduction:Abnormal cell proliferation appears to be a possible predictor of tumorigenesis, Ki-67 protein expression is closely related to the cell proliferation and could be used as a biomarker for the growth in the most of human tumors. The aim of the study: Investigating of Ki-67 expression in the pathological grades of oral epithelial dysplasia and oral squamous cell carcinomas.Materials and Methods:The sample consisted of 30 formalin-fixed, paraffin-embedded specimens of oral epithelial dysplasia (OED), 30 other of oral squamous cell carcinomas (OSCC), and 10 normal oral epithelium (NOE) were conventionally stained with hematoxylin and eosin and immunohistochemically stained with Ki-67 monoclonal antibody.Results:Expression of Ki-67 was restricted to the basal layers in the normal oral epithelium whereas Ki-67 positive cells in oral epithelial dysplasia (OED) were located in the basal, suprabasal and spinous layers, Ki-67 expression was increased in high-risk cases. Ki-67 positive cells in well-differentiated (OSCC) were located mainly in the periphery of the tumor nests, in moderately-differentiated (OSCC) were located in both peripheral and part of a center of the tumor nests whereas it was diffused in most of the Poorly-differentiated (OSCC). Statistical analysis indicated a significant difference between the expression in (OED) and (NOE), (OSCC) and (NOE), and no differences between (OED) and (OSCC).Conclusion:This study has concluded that Ki-67 antigen could be used as a marker for the histological grading of OED and OSCC, Expression of Ki 67 increased according to the severity of oral epithelial dysplasia.

show abstract

Analysis of Incidence of Clinically Diagnosed Oral Leukoplakia Patients Undergoing Incisional Biopsy Using Certainty Factor: An Institutional Study

Thamilselvan¹,

Ramasubramanian²,

Ramani³

et al. 2022

World Journal of Dentistry

View full text Add to dashboard Cite

Oral Leukoplakia – Is Biopsy at the Initial Appointment a Must?

Cited by 3 publications

References 24 publications

Oral epithelial dysplasia and oral cancer prevalence in routine white lesion biopsies – a 6-year retrospective study

Oral epithelial dysplasia and oral cancer prevalence in routine white lesion biopsies – a 6-year retrospective study

Ki-67 Prognostic Value in Different Histological Grades of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Analysis of Incidence of Clinically Diagnosed Oral Leukoplakia Patients Undergoing Incisional Biopsy Using Certainty Factor: An Institutional Study

Contact Info

Product

Resources

About