Oral microbiota affects the efficacy and prognosis of radiotherapy for colorectal cancer in mouse models

Dong, Jing; Li, Yuan; Xiao, He; Zhang, Shuqin; Wang, Bin; Wang, Haichao; Li, Yiliang; Fan, Saijun; Cui, Ming

doi:10.1016/j.celrep.2021.109886

Cited by 44 publications

(41 citation statements)

References 55 publications

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“…Moreover, it can migrate to the CRC locus, impair the therapeutic efficacy of radiotherapy, and affect patient prognosis. The use of metronidazole to kill F. nucleatum can reduce CRC radiotherapy resistance induced by oral microbiota (Dong et al, 2021). To enhance the chemotherapy effect of CRC, Zheng et al (2019) linked the F. nucleatum-specific phage with dextran nanoparticles loaded with CRC chemotherapeutic drugs form phage-guided nanoparticles, which can effectively inhibit the growth of F. nucleatum, significantly prolong the survival time of CRC mice and reduce the number of adenomas in Apc mice prone to intestinal adenomas.…”

Section: Crcmentioning

confidence: 99%

More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

Chen

Huang

Tang

et al. 2022

Front. Cell. Infect. Microbiol.

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Fusobacterium nucleatum is a common oral opportunistic bacterium that can cause different infections. In recent years, studies have shown that F. nucleatum is enriched in lesions in periodontal diseases, halitosis, dental pulp infection, oral cancer, and systemic diseases. Hence, it can promote the development and/or progression of these conditions. The current study aimed to assess research progress in the epidemiological evidence, possible pathogenic mechanisms, and treatment methods of F. nucleatum in oral and systemic diseases. Novel viewpoints obtained in recent studies can provide knowledge about the role of F. nucleatum in hosts and a basis for identifying new methods for the diagnosis and treatment of F. nucleatum-related diseases.

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Section: Crcmentioning

confidence: 99%

More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

Chen

Huang

Tang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…In parallel, oral Th17 cells induced by oral pathobiont expansion migrate to the gut and promote colitis, constituting both microbial and immunological pathways that link oral and gut health. Furthermore, Dong et al showed that the alterations of the oral microbiota, especially F. nucleatum colonization in CRC locus, can change the gut bacterial composition within tumours and influence the therapeutic efficacy and prognosis of radiotherapy for primary rectal cancer and CRC liver metastases in mouse models [ 125 ]. Kartal et al applied shotgun metagenomic and 16S rRNA sequencing to faecal and saliva samples from pancreatic ductal adenocarcinoma (PDAC) to identify diagnostic classifiers [ 96 ].…”

Section: Oral Pathogens and Systemic Diseasesmentioning

confidence: 99%

Leaky Gum: The Revisited Origin of Systemic Diseases

Park¹,

Park²,

Lee³

et al. 2022

Cells

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The oral cavity is the gateway for microorganisms into your body where they disseminate not only to the directly connected respiratory and digestive tracts but also to the many remote organs. Oral microbiota, travelling to the end of the intestine and circulating in our bodies through blood vessels, not only affect a gut microbiome profile but also lead to many systemic diseases. By gathering information accumulated from the era of focal infection theory to the age of revolution in microbiome research, we propose a pivotal role of “leaky gum”, as an analogy of “leaky gut”, to underscore the importance of the oral cavity in systemic health. The oral cavity has unique structures, the gingival sulcus (GS) and the junctional epithelium (JE) below the GS, which are rarely found anywhere else in our body. The JE is attached to the tooth enamel and cementum by hemidesmosome (HD), which is structurally weaker than desmosome and is, thus, vulnerable to microbial infiltration. In the GS, microbial biofilms can build up for life, unlike the biofilms on the skin and intestinal mucosa that fall off by the natural process. Thus, we emphasize that the GS and the JE are the weakest leaky point for microbes to invade the human body, making the leaky gum just as important as, or even more important than, the leaky gut.

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“…Dong and colleagues showed that F. nucleatum migrates from the oral cavity to the intestine, where it harbours within colorectal cancers and promotes radioresistance. Given the accumulated evidence pointing towards a role of F. nucleatum in modulating inflammation and driving HN-SCC, these results may offer new avenues of research [104].…”

Section: Efficacy Studiesmentioning

confidence: 88%

The microbiota and radiotherapy for head and neck cancer: What should clinical oncologists know?

Ferreira¹,

Pastò²,

Ng³

et al. 2022

Cancer Treatment Reviews

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Oral microbiota affects the efficacy and prognosis of radiotherapy for colorectal cancer in mouse models

Cited by 44 publications

References 55 publications

More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum

Leaky Gum: The Revisited Origin of Systemic Diseases

The microbiota and radiotherapy for head and neck cancer: What should clinical oncologists know?

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