Oral potentially malignant disorders: clinical-pathological study of 684 cases diagnosed in a Brazilian population

Pires, Fábio Ramôa; Barreto, Maria Eduarda Zeraik; Nunes, Jéssica Gomes Rodrigues; Carneiro, Natália Santos; Azevedo, Alexandro Barbosa de; Santos, Teresa Cristina Ribeiro Bartholomeu dos

doi:10.4317/medoral.23197

Cited by 14 publications

(17 citation statements)

References 20 publications

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“…Some clinical predictors of the malignancy of OL are advanced age, female gender, smoking, long duration of the lesion, diameter greater than two centimetres, non-homogeneous type, location on the tongue’s lateral edge or the mouth’s floor, and presence of OED [ 5 , 9 , 10 ]. The chances of a malignant transformation occurring in a longer and larger lesion are higher than in a small lesion [ 3 ]. Although this case’s patient did not know the evolution timeline, and the lesion’s small size at the time of diagnosis, the presence of OED was established.…”

Section: Discussionmentioning

confidence: 99%

“…Alterations in the epithelium’s tissue architecture were found, with atypical cells. OL without dysplasia has a worldwide prevalence of 4.1%, whereas, when with OED, the prevalence is of 4.4% [ 3 ]. Among the microscopic findings, irregular stratification of the parabasal epithelium, hyperchromatism, and nuclear pleomorphism were observed, characteristics already described in the literature [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Among the oral lesions that present malignant transformation potentiality are leucoplakia, erythroplakia, erythroleukoplakia, and actinic keratosis [ 3 ]. Most of the agents associated with oral cancer development are also involved in the aetiology of OPMDs, such as chronic exposure to ultraviolet radiation, alcohol consumption, tobacco use (smoking), nutritional deficiency, and genetic inheritance [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, OL is a clinical term used to describe white plaques of questionable risk, which does not fall under any other classification of this group [ 2 ]. The prevalence of OL is of 1 to 4% in the world population, being the OPMDs are more common, representing 85% of these lesions [ 3 ]. This disorder’s clinical aspect represents two types, classified as homogeneous or non-homogeneous OL [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Small Dysplastic Oral Leucoplakia in a Smoking Woman: a Case Report

Pedroso¹,

Schemberger²,

Dziadzio³

et al. 2021

JOMR

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Background Oral leucoplakia is clinical term used to describe white plaques, and that is part of the group of oral potentially malignant disorders. Leucoplakia may show epithelial dysplasia, mainly in harder smoking patient. This case report discusses a small leucoplakia with dysplasia on the tongue’s lateral border in a woman, diagnosed early after a routine clinical consultation. Methods A 57-year-old female patient consulted to the Oral Diagnosis and Surgery Service of the State University of Ponta Grossa, Brazil. First, the patient was referred for the extraction of her lower incisors due to periodontal disease. During clinical examination, was identified a sessile white plaque, of small size, and located on the tongue’s left lateral border. Thus, the lesion’s diagnostic hypothesis was oral leucoplakia due to patient be chronic smoker for 40 years. The incisional biopsy was performed, with the epithelial tissue and part of the connective tissue removed. Results The histopathological examination revealed a stratified and keratinized pavement epithelium, with cellular atypia, and presence of hyperchromatism and nuclear pleomorphism. However, the alterations were restricted to the epithelium’s basal, characterizing a mild dysplasia. The proposed treatment was surgical removal of the lesion, and the patient was also instructed to quit smoking, as well as she continues to follow-up. Conclusions The presented case emphasizes the importance of early diagnosis and the orientation of risk factors to smoking patients, even in small lesions that can clinically appear harmless.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Small Dysplastic Oral Leucoplakia in a Smoking Woman: a Case Report

Pedroso¹,

Schemberger²,

Dziadzio³

et al. 2021

JOMR

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“…A significant number of OSCCs develop from a group of precursor lesions [ 5 ] termed “potentially malignant disorders” by the World Health Organization (WHO) and encompassing lesions or conditions at risk of malignant transformation [ 6 ]. The most common of these oral potentially malignant disorders (OPMD) are leukoplakia, oral lichen planus, and actinic cheilitis [ 7 ]. Oral leukoplakia (OLK) presents as a white area or plaque that cannot be characterized as any other lesion clinically or histologically, and is the most common OPMD, with a prevalence between 0.6% to 4.6% [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of MicroRNA Signatures Associated with the Progression of Leukoplakia with and without Epithelial Dysplasia

et al. 2021

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Oral cancer is a significant public health issue, being the eighth most common cancer worldwide with over 300,000 cases diagnosed annually. Early diagnosis and adequate management of oral potentially malignant disorders (OPMDs) before transformation into oral squamous cell carcinoma (OSCC) is critical to reduce deaths, morbidity, and to improve overall prognosis. MicroRNAs (miRNAs) are small noncoding RNAs involved in the post-transcriptional regulation of protein expression and implicated in the control of numerous cellular pathways and impacting physiological, developmental, and pathological processes. Dysregulation of miRNAs has been reported in many cancers and has been demonstrated to play a critical role in cancer initiation, progression, apoptosis, invasion and metastasis. This systematic review provides a comprehensive summary of the prevailing literature on miRNA signatures in OPMDs, specifically leukoplakia with or without oral epithelial dysplasia, and their utility in predicting malignant transformation into OSCC. Eighteen articles describing 73 unique and differentially expressed microRNAs met the criteria for inclusion in this review. We reviewed the characteristics and methodology for each of these studies and assessed the sensitivity and specificity of the studied miRNAs in predicting malignant transformation. This systematic review highlights the significant interest in miRNAs and their tremendous potential as prognostic markers for predicting the malignant transformation of OPMDs into OSCC.

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Analysis on the Knowledge about Oral Potentially Malignant Disorders of a Male Motorcycle Community in Indonesia

Ahmada,

Ramadhanti,

Surboyo

et al. 2023

Journal of Health and Allied Sciences NU

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Background Oral potentially malignant disorders (OPMDs) are a group of oral lesions or conditions with a higher risk of malignant transformation. OPMD affects 4.47% of people worldwide, with predilection in males. The high tendency of frequent tobacco smoking and alcohol consumption may lead the male motorcycle community to have a higher risk for developing OPMD and malignant transformation. Objectives This article determines the level of knowledge about OPMD within a male motorcycle community. Methods This study uses a survey research design that is a questionnaire-based and descriptive study. Data were obtained using a Google Form, and IBM SPSS was used for analysis. Simple random sampling is the sampling method applied. The total knowledge score is divided into three levels, low (0–4), moderate (5–9), and high (10–15). Results The questionnaire was finished by 60 people entirely. All respondents (100%) were men, and the majority (83.00%) was aged between 20 and 21. A total of 26 respondents (43.30%) had moderate knowledge levels, followed by 21 with high knowledge levels (35.0%), and 13 with low knowledge levels (21.70%). Conclusion The majority of the male motorcycle community (43.30%) has a moderate knowledge level regarding OPMD. This study indicates the need for educational measures to improve awareness regarding OPMD in a high-risk community.

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Oral potentially malignant disorders: clinical-pathological study of 684 cases diagnosed in a Brazilian population

Cited by 14 publications

References 20 publications

Small Dysplastic Oral Leucoplakia in a Smoking Woman: a Case Report

Small Dysplastic Oral Leucoplakia in a Smoking Woman: a Case Report

A Systematic Review of MicroRNA Signatures Associated with the Progression of Leukoplakia with and without Epithelial Dysplasia

Analysis on the Knowledge about Oral Potentially Malignant Disorders of a Male Motorcycle Community in Indonesia

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