Oral sucrose for pain control in nonneonate infants during minor painful procedures

Abstract

Oral sucrose solution should be used as a pain reduction intervention in infants up to 12 months of age undergoing minor painful procedures. Its proven effectiveness as an analgesic, low rate of minor adverse events, ease of administration, and excellent availability make sucrose a good choice for this purpose. Additional research is needed regarding dose response in different infant age groups, optimal concentration of sucrose solution, need for multiple sucrose dosing, adjustment for multiple painful procedures, and addition of optimal nonpharmacologic interventions as a combination approach.

Live Music Therapy as an Active Focus of Attention for Pain and Behavioral Symptoms of Distress During Pediatric Immunization

“…Various measures to reduce pain during immunization have been explored, including breastfeeding during immunization procedure, use of topical anesthetics, oral analgesics, oral sucrose solutions, positioning, tactile stimulation, skin-cooling techniques, use of microneedles, skin-toskin care, psychological interventions, distraction, music therapy, and so on. [4][5][6][7][8][9][10] Music therapy offers a safe and harmless intervention for reducing pain in children.…”

Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq

“…Sucrose (4.5%) is an important nutrient energy source, but its imbalance or excessive consumption has multiple deleterious effects on human health [ 66 , 67 ]. It has been also demonstrated to exert pain preventive effect on infants [ 68 , 69 ].…”

Eficácia de métodos farmacológicos e não farmacológicos de manejo da dor em crianças durante venipuntura: uma revisão narrativa

“…Em contrapartida, o estudo de McCall et al (2013) mostrou que a administração de sacarose oral pré-procedimento apresenta benefícios analgésicos em bebês de até 12 meses de idade durante injeções intramusculares e punção venosa, sustentando a ideia de ser uma boa opção para prevenir a dor, além de mostrar baixa taxa de eventos adversos, facilidade de administração e grande disponibilidade (McCall et al, 2013). Ademais, Desjardins et al (2016) realizou uma pesquisa com crianças de 28 dias a 3 meses de idade que obtiveram acesso venoso, divididas em grupo controle e de intervenção, o qual recebeu sacarose, encontrando uma diferença estatisticamente significativa nos tempos médios de choro entre os grupos, sendo 41 e 17 segundos respectivamente (Desjardins et al, 2016).…”