Oral tranexamic acid for the treatment of melasma

Abstract

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Tratamiento de melasma refractario con ácido tranexámico oral como monoterapia: reporte de un caso y revisión de la literatura

“…Otros mecanismos de acción propuestos del AT en el melasma son la inhibición de la interacción queratinocito-melanocito (al reducir el transporte de gránulos de melanina), activación del sistema autofágico celular con la consecuente degradación de los melanosomas. El AT también puede inhibir la angiogénesis y disminuir la expresión del factor de crecimiento vascular endotelial y la endotelina 1,8,[11][12][13] .…”

Comparison of efficacy and safety of tranexamic acid mesotherapy versus oral tranexamic acid in patients with melasma undergoing Q‐switched fractional 1064‐nm Nd:YAG laser: A blinded RCT and follow‐up

“…There are several methods for the treatment of melasma; however, no single treatment has been discovered with the ability to maintain and control melisma effectively 1 . Moreover, the treatment of melasma becomes challenging for clinicians and frustrating for patients 2 …”

“…1 Moreover, the treatment of melasma becomes challenging for clinicians and frustrating for patients. 2 Topical hydroquinone plus tretinoin have been the most effective treatment for melasma, but during long-term use for lightening the spots, it accompanies undesirable side effects such as skin irritation and hyperpigmentation after paradoxical inflammation; so, the use of this combination can lead to a difficult situation. 3 Although laser therapy in melasma disorder can stimulate melanocytes and inflammatory processes, the use of low-energy Q-switched with recurrent episodes is recognized as a safe and effective method in melasma treatment.…”