Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients

Fernández, Antonio J. Sánchez; Cordero, Mario D.; Garrido-Maraver, Juan; Alcocer-Gómez, Elísabet; Barquero, N. Casas; Carmona-López, María Inés; Sánchez-Alcázar, José Antonio; Miguel, Manuel de

doi:10.1016/j.jpsychires.2011.11.002

Cited by 49 publications

(30 citation statements)

References 26 publications

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“…Dessa forma, os artigos que foram lidos na íntegra e não incluídos na análise crítica, por não preencherem os critérios de inclusão, muitas vezes foram citados na discussão. Os temas abordados nesses artigos foram o estresse oxidativo e a suplementação com coenzima Q10 (coQ10), 25,[27][28][29][30]32 composição corporal e sintomas da fibromialgia 35,37,39 e deficiência de vitamina D e sua influência na fibromialgia. 41 17 os autores analisaram artigos sobre dietas vegetarianas, ricas em antioxidantes, embora existam poucos estudos e com número pequeno de indivíduos.…”

Section: Resultsunclassified

“…A suplementação com CoQ10 pode prevenir ou reduzir os efeitos de amitriptilina. 32 Outros efeitos relacionados ao tratamento medicamentoso podem ser citados, como ganho de peso, edema, constipação e náusea. 33 O índice de massa corporal (IMC) aumentado influencia na qualidade do sono, hiperalgesia e na qualidade de vida, o que pode complicar o quadro clínico, na medida em que a força física e a flexibilidade são afetadas, além da sensibilidade à dor, especialmente na parte inferior do corpo.…”

Section: Discussionunclassified

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Recomendações Nutricionais Para O Tratamento Da Fibromialgia

Silva

Schieferdecker

2017

DEMETRA

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A fibromialgia é uma síndrome clínica caracterizada pela presença de dor crônica, fadiga, alterações de sono, ansiedade e depressão. O objetivo desta revisão foi atualizar os conhecimentos dietoterápicos acerca da fibromialgia. Realizou-se uma revisão integrativa, na qual foram consultadas as bases de dados Science Direct, Medline Pubmed e Scientific Electronic Library Online (Scielo) no período de julho a setembro de 2016, com os descritores fibromyalgia e nutrition, buscando artigos originais, de revisão, guias e consensos de recomendações nacionais e internacionais publicados de 2003 a 2016. A fibromialgia ocorre com maior frequência em mulheres com 35 a 60 anos, comumente com sobrepeso ou obesidade. Existem poucos estudos originais sobre nutrientes ou terapia nutricional para fibromialgia, não há recomendações nutricionais específicas. Existe relação importante com o estresse oxidativo, em que possivelmente há disfunção mitocondrial, o que tornaria benéfica a terapia com nutrientes antioxidantes, como as vitaminas C, E o β-caroteno. Há relatos da redução da vitamina E em indivíduos com fadiga e depressão. Alguns temas abordados em estudos foram o estresse oxidativo e a suplementação com coenzima Q10 (coQ10), a relação entre a composição corporal e sintomas da fibromialgia e a deficiência de vitamina D. A fadiga pode ser agravada em indivíduos com sensibilidade ao glúten não celíaca, contudo, ainda são necessários estudos que investiguem melhor essa relação. Embora não existam recomendações nutricionais específicas, esses enfermos podem beneficiar-se com dieta baseada nos princípios da nutrição saudável, rica em antioxidantes, e da redução de peso, quando houver indicação.

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Section: Discussionunclassified

Recomendações Nutricionais Para O Tratamento Da Fibromialgia

Silva

Schieferdecker

2017

DEMETRA

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“…Depressed patients have lower mitochondrial ATP production, lower CoQ10 levels and increased mitochondrial ROS, all of which indicate mitochondrial damage [60–63]. The mitochondrial impairments may be due to increased mtDNA damage, and elevated levels of mtDNA deletions are found in depressed patients’ muscles and PBMCs [61,62]. Such deletions can be triggered by DNA damage, and one of the most frequently occurring deletions, called “common deletion”, is triggered by a single-strand break following incomplete DNA damage repair, when ligase does not seal the nick in the last step of BER [64].…”

Section: Discussionmentioning

confidence: 99%

Single-Nucleotide Polymorphisms of Genes Involved in Repair of Oxidative DNA Damage and the Risk of Recurrent Depressive Disorder

et al. 2016

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BackgroundDepressive disorder, including recurrent type (rDD), is accompanied by increased oxidative stress and activation of inflammatory pathways, which may induce DNA damage. This thesis is supported by the presence of increased levels of DNA damage in depressed patients. Such DNA damage is repaired by the base excision repair (BER) pathway. BER efficiency may be influenced by polymorphisms in BER-related genes. Therefore, we genotyped nine single-nucleotide polymorphisms (SNPs) in six genes encoding BER proteins.Material/MethodsUsing TaqMan, we selected and genotyped the following SNPs: c.-441G>A (rs174538) of FEN1, c.2285T>C (rs1136410) of PARP1, c.580C>T (rs1799782) and c.1196A>G (rs25487) of XRCC1, c.*83A>C (rs4796030) and c.*50C>T (rs1052536) of LIG3, c.-7C>T (rs20579) of LIG1, and c.-468T>G (rs1760944) and c.444T>G (rs1130409) of APEX1 in 599 samples (288 rDD patients and 311 controls).ResultsWe found a strong correlation between rDD and both SNPs of LIG3, their haplotypes, as well as a weaker association with the c.-468T>G of APEXI which diminished after Nyholt correction. Polymorphisms of LIG3 were also associated with early onset versus late onset depression, whereas the c.-468T>G polymorphism showed the opposite association.ConclusionsThe SNPs of genes involved in the repair of oxidative DNA damage may modulate rDD risk. Since this is an exploratory study, the results should to be treated with caution and further work needs to be done to elucidate the exact involvement of DNA damage and repair mechanisms in the development of this disease.

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“…Beta blockers propranolol and metoprolol [Kishi et al, 1977], and phenothiazines and tricyclic antidepressants have been shown to inhibit CoQ 10 -dependent enzymes [Moreno-Fernández et al, 2012]. CoQ 10 's effects on platelet function may increase the risk of bleeding in patients taking antiplatelet drugs such as aspirin [Serebruany et al, 1997].…”

Section: Drug-nutrient Interactionsmentioning

confidence: 99%

Coenzyme Q<sub>10</sub> Therapy

Garrido-Maraver¹,

Cordero²,

et al. 2014

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For a number of years, coenzyme Q₁₀ (CoQ₁₀) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in blood plasma, and extensively investigated its antioxidant role. These 2 functions constitute the basis for supporting the clinical use of CoQ₁₀. Also, at the inner mitochondrial membrane level, CoQ₁₀ is recognized as an obligatory cofactor for the function of uncoupling proteins and a modulator of the mitochondrial transition pore. Furthermore, recent data indicate that CoQ₁₀ affects the expression of genes involved in human cell signaling, metabolism and transport, and some of the effects of CoQ₁₀ supplementation may be due to this property. CoQ₁₀ deficiencies are due to autosomal recessive mutations, mitochondrial diseases, aging-related oxidative stress and carcinogenesis processes, and also statin treatment. Many neurodegenerative disorders, diabetes, cancer, and muscular and cardiovascular diseases have been associated with low CoQ₁₀ levels as well as different ataxias and encephalomyopathies. CoQ₁₀ treatment does not cause serious adverse effects in humans and new formulations have been developed that increase CoQ₁₀ absorption and tissue distribution. Oral administration of CoQ₁₀ is a frequent antioxidant strategy in many diseases that may provide a significant symptomatic benefit.

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Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients

Cited by 49 publications

References 26 publications

Recomendações Nutricionais Para O Tratamento Da Fibromialgia

Recomendações Nutricionais Para O Tratamento Da Fibromialgia

Single-Nucleotide Polymorphisms of Genes Involved in Repair of Oxidative DNA Damage and the Risk of Recurrent Depressive Disorder

Coenzyme Q<sub>10</sub> Therapy

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