Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease

Silva, Tiago Guardia de Souza e; Paulo, Maria Eliza Ferreira do Val de; Silva, Jeferson Rubens Mamona da; Alves, Adilson da Silva; Britto, Luiz Roberto Giorgetti de; Xavier, Gilberto Fernando; Sandoval, Maria Regina Lopes

doi:10.1016/j.heliyon.2020.e03281

Cited by 35 publications

(27 citation statements)

References 79 publications

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“…Therefore, it is assumed that orally administered ACh is mostly degenerated in the process of absorption and blood transport before it reaches the ACh receptor expressed in brain cholinergic synapses and autonomously innervated organs, such as smooth muscles of blood vessels and intestines, pancreas, and LGs. Nevertheless, it has been reported that orally administered RJ has ACh-like effects, such as improvement of Alzheimer’s disease [ 35 ], vasodilation induced by nitric oxide production [ 36 ], and induction of insulin secretion [ 37 ]. Moreover, our previous report showed that RJ had a tear secretion capability via muscarinic acetylcholine receptor (mAChR) signaling induced by intracellular Ca 2+ increase in LGs, which was suppressed by the mAChR antagonist atropine and by inhibitors of phospholipase C and ER-Ca 2+ -ATPase essential enzyme pathways [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice

Yamaga¹,

Iwasaku

Tani³

et al. 2021

Nutrients

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Dry eye is a multifactorial disease characterized by ocular discomfort and visual impairment. Our previous studies have shown that royal jelly (RJ) has restored the capacity for tear secretion by modulating muscarinic calcium signaling. RJ contains acetylcholine, which is a major cholinergic neurotransmitter, and a unique set of fatty acids with C 8 to 12 chains, which are expected to be associated with health benefits. The purpose of the present study was to investigate the active components involved in tear secretion capacity, focusing on acetylcholine and fatty acids in RJ. Using the stress-induced dry-eye model mice, it was confirmed that acetylcholine with three fatty acids (10-hydroxydecanoic acid, 8-hydroxyoctanoic acid, and (R)-3,10-dihydroxydecanoic acid) was essential for tear secretion. In ex vivo Ca2+ imaging, these three fatty acids suppressed the decrease in intracellular modulation of Ca2+ in the lacrimal gland by acetylcholine when treated with acetylcholinesterase, indicating that the specific type of RJ fatty acids contributed to the stability of acetylcholine. To our knowledge, this study is the first to confirm that a specific compound combination is important for the pharmacological activities of RJ. Our results elucidate the active molecules and efficacy mechanisms of RJ.

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Section: Discussionmentioning

confidence: 99%

Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice

Yamaga¹,

Iwasaku

Tani³

et al. 2021

Nutrients

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“…RJ significantly improved spatial learning and enhanced memory retention by up to 48.5% in normally aged rats [ 107 , 108 , 109 , 110 ]. It also corrected cognitive deficits in different AD models such as copper and cholesterol-fed rabbits [ 70 ], streptozotocin-induced hippocampal neuronal death [ 111 ], trimethyltin-induced hippocampal neuronal death [ 112 ], and double transgenic APP/PS1 mice, which express two mutations associated with early-onset AD—chimeric mouse/human APP (Mo/HuAPP695swe) and human PS1 (PS1-dE9) [ 28 ].…”

Section: Effect Of Royal Jelly On Cognitive Performance and Relatementioning

confidence: 99%

Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review

Ali

2020

Antioxidants

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The astronomical increase of the world’s aged population is associated with the increased prevalence of neurodegenerative diseases, heightened disability, and extremely high costs of care. Alzheimer’s Disease (AD) is a widespread, age-related, multifactorial neurodegenerative disease that has enormous social and financial drawbacks worldwide. The unsatisfactory outcomes of available AD pharmacotherapy necessitate the search for alternative natural resources that can target various the underlying mechanisms of AD pathology and reduce disease occurrence and/or progression. Royal jelly (RJ) is the main food of bee queens; it contributes to their fertility, long lifespan, and memory performance. It represents a potent nutraceutical with various pharmacological properties, and has been used in a number of preclinical studies to target AD and age-related cognitive deterioration. To understand the mechanisms through which RJ affects cognitive performance both in natural aging and AD, we reviewed the literature, elaborating on the metabolic, molecular, and cellular mechanisms that mediate its anti-AD effects. Preclinical findings revealed that RJ acts as a multidomain cognitive enhancer that can restore cognitive performance in aged and AD models. It promotes brain cell survival and function by targeting multiple adversities in the neuronal microenvironment such as inflammation, oxidative stress, mitochondrial alterations, impaired proteostasis, amyloid-β toxicity, Ca excitotoxicity, and bioenergetic challenges. Human trials using RJ in AD are limited in quantity and quality. Here, the limitations of RJ-based treatment strategies are discussed, and directions for future studies examining the effect of RJ in cognitively impaired subjects are noted.

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“…It is also used as a semen diluent due to its sperm quality and fertility-enhancing properties (Ghanbari et al 2015 ). In a study conducted by creating a sporadic Alzheimer’s disease model in 2020, it was stated that royal jelly has positive effects on memory and neuroprotective effects in rats (Silva et al 2020 ). Latterly, honeybee and royal jelly products have been recommended as a potential coherent antiseptic to help preserve against the Covid-19 based on the biocidal effect of H 2 O 2 and other phytochemicals existing in bee and royal jelly products (Shaldam et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The inducing of caspase and Bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats

Aslan

Can

Gök

et al. 2021

Environ Sci Pollut Res

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Graphical abstract In this study, 42 Wistar albino male rats ( n = 42, 8 weeks old) were used. Rats were divided into 6 groups and 7 rats included each group. Groups: (i) Control group: Standard diet; (ii) RJ (royal jelly) group: Standard diet + royal jelly; (iii) F50 group: Standard diet + 50 mg/kg fluoride; (iv): F100 group: Standard diet + 100 mg/kg fluoride; (v) F50+RJ group: Standard diet + 50 mg/kg fluoride + royal jelly; (vi): F100+RJ group: Standard diet + 100 mg/kg fluoride + royal jelly. After 8 weeks, the rats were decapitated, and their muscle tissues were removed. Expression levels of Caspase-3, Caspase-6, Bax, tumor necrosis factor-α (TNF-α), interleukin 1 alpha (IL1-α) and Bcl-2 proteins in muscle tissue were determined by western blotting method. Histopathological analyses were also performed on the muscle tissue. Malondialdehyde (MDA), glutathione (GSH) and catalase (CAT) analyses were determined by a spectrophotometer. According to the obtained results, Bcl-2, TNF-α and IL1-α protein expression was increased in damage groups compared to the control and royal jelly groups, while Caspase-3, Caspase-6 and Bax protein expression levels decreased in damage groups. MDA level increased in damage groups compared to the control and royal jelly groups, while CAT and GSH levels increased with royal jelly application in royal jelly-given group in comparison to the flouride-exposed group. According to histopathological analysis results, edema and inflammatory cell formations were found in the injury groups, a tendency to decrease in these injuries was observed in the treatment groups. Based on these results, we can say that royal jelly has protective effects on muscle tissue against fluoride damage.

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Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease

Cited by 35 publications

References 79 publications

Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice

Acetylcholine and Royal Jelly Fatty Acid Combinations as Potential Dry Eye Treatment Components in Mice

Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review

The inducing of caspase and Bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats

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