The inducing of caspase and Bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats

Aslan, Abdullah Nabi; Can, Muhammed İsmail; Gök, Özlem; Beyaz, Seda; Parlak, Gozde; Ozercan, İbrahim Hanifi

doi:10.1007/s11356-021-16456-z

Cited by 10 publications

(3 citation statements)

References 26 publications

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“…The findings of quantitative real-time PCR displayed that the expression level of Bcl2 was considerably ( p < 0.05) downregulated in the tumor after treatment of the EST-suffering mice with RJ at the doses of 200 and 400 mg/kg, respectively. Similarly, Aslan et al and Ali et al, have demonstrated that royal jelly elevates the caspase and Bcl-2 expression level and subsequently declined the muscle tissue injury induced with fluoride in rats [ 56 , 57 ].…”

Section: Resultsmentioning

confidence: 99%

Antitumor Activity of Royal Jelly and Its Cellular Mechanisms against Ehrlich Solid Tumor in Mice

Albalawi

Althobaiti

Alrdahe

et al. 2022

BioMed Research International

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Objective. The present study was aimed at evaluating the antitumor effects of royal jelly (RJ) obtained from Apis mellifera compared with cyclophosphamide against the Ehrlich solid tumors (EST) in mice. Methods. Tumor growth inhibition, body weight, the serum level of alpha-fetoprotein (AFP) and carcinoembryonic antigen tumor (CAE), liver and kidney enzymes, tumor lipid peroxidation (LPO), nitric oxide (NO), antioxidant enzymes (glutathione peroxidase (GPx), catalase enzyme (CAT), and superoxide dismutase enzyme activity (SOD)), tumor necrosis factor alpha level (TNF-α), and the apoptosis-regulatory genes expression were assessed in EST mice treated with RJ (200 and 400 mg/kg orally once a day for 2 weeks). Results. The results showed that treatment of EST-suffering mice with RJ at the doses of 200 and 400 mg/kg causes significant reduction in tumor volume and inhibition rate, body weight, tumor markers (AFP and CEA), serum level of liver and kidney, LPO and NO, TNF-α level, as well as the expression level of Bcl-2 in comparison with the EST mice receiving the normal saline; whereas RJ at the doses of 200 and 400 mg/kg/day significantly increased ( p < 0.05 ) the level of antioxidant enzymes of GPx, CAT, and SOD and the expression level of caspase-3 and Bax genes. Conclusion. The findings revealed that oral administration of royal jelly especially at the doses of 200 and 400 mg/kg exhibited promising antitumor effects against EST in mice through induction of apoptosis as well as its antioxidant and anti-inflammatory effects, which suggest it as a novel anticancer agent against tumor; however, additional surveys especially in clinical setting are necessary to approve these findings.

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Section: Resultsmentioning

confidence: 99%

Antitumor Activity of Royal Jelly and Its Cellular Mechanisms against Ehrlich Solid Tumor in Mice

Albalawi

Althobaiti

Alrdahe

et al. 2022

BioMed Research International

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“…On the other hand, inflammatory factors are also important. TNF-α can promote apoptosis by increasing caspase (44). However, the anti-inflammatory effects of exercise and resveratrol on reducing TNF-α have been reported as well (43).…”

Section: Discussionmentioning

confidence: 99%

The combined effect of eight-week resveratrol supplementation and interval training on some regulatory and executive factors of hepatocyte apoptosis in male rats with diabetes

Negarestani

Nobahar

Mehri

2022

J Shahrekord Univ Med Sci

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Background and aims: The aim of this study was to investigate the combined effect of interval training and resveratrol consumption on the regulatory and executive factors of hepatocyte apoptosis in male rats with diabetes. Methods: Frothy-two male Wistar rats were randomly divided into healthy control, diabetic, saline diabetic, resveratrol supplement, intermittent exercise, and resveratrol+intermittent exercise groups. The interval training program consisted of 8 weeks of training with an intensity of 50%-70% of the maximum oxygen consumption. Resveratrol was injected in two training groups with resveratrol supplement and resveratrol+supplement at a dose of 20 mg. Results: The concentrations of caspase-3 and BAX in diabetic saline and diabetic groups were significantly higher than in control groups (P=0.001). On the other hand, Bcl-2 (B-cell lymphoma 2) levels in diabetic saline and diabetic were significantly lower than in the control groups (P=0.001). The concentration of the BAX/Bcl-2 ratio in diabetic and diabetic saline was significantly higher compared to control groups (P=0.001) The effect of interval training, administration of resveratrol alone, or especially with interval training caused a significant decrease in the concentration of BAX and caspase-3 (P=0.001), a significant increase in the mean Bcl-2 concentration (P=0.001), and a significant decrease in the mean BAX/Bcl-2 ratio (P=0.001) in male rats with diabetes compared with the diabetic and diabetic groups. Conclusion: The combined effect of eight-week resveratrol supplementation and interval training decreased apoptosis markers, while it increased the concentration of Bcl-2 in male rats with type 2 diabetes.

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“…Group 3 (glucocorticoid + ALA treated group): Rats were injected with methyl-prednisolone in the same dose as the previous group for 2 months, the rats were administrated simultaneously with ALA solution with a gastric tube in a dose of 100mg/kg/day for the same period (11) . Group 4 (glucocorticoid + Royal jelly treated group): Rats were injected with methyl-prednisolone in the same dose as group II, and were fed by gastric tube with RJ in a dosage of 100mg/kg B.W per day simultaneously (13). One day after the last dose, rats of all studied groups were anesthetized with intraperitoneal injection of sodium thiopental 200mg/kg BW (14) Then, the shaft of the femur of all animals was cautiously dissected and handled for histological studies.…”

Section: Experimental Designmentioning

confidence: 99%

The Possible Pre-emptive Role of Royal Jelly and Alpha Lipoic Acid on Osteoporosis Caused by Glucocorticoid in Adult Male Albino Rats

Ibrahim¹,

Abdow²

2022

The Egyptian Journal of Hospital Medicine

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Introduction: extreme or extended glucocorticoid (GC) management may lead to high risk of bone fractures and osteoporosis (OP). Alpha lipoic acid and Royal Jelly are effective anti-oxidants. Objective: This study examined effects of glucocorticoid on the bone structure and the possible preventive role of alpha Lipoic acid and royal jelly. Materials and Methods: Forty rats were categorized into four groups. Control group, corticosteroid group: rats were administrated with glucocorticoid at a dose of 30 mg/kg/day S.C for 60 days, third group rats were given Glucocorticoid and 100 mg/kg/day of alpha lipoic acid orally for 60 days. Group IV: rats were given glucocorticoid and royal jelly 100 mg/Kg /day orally for 2 months. Bone specimens were prepared for the histological and immunohistochemical studies. Results: Glucocorticoid induced resorption and damage of the bone histological structure. Percent of both collagen fibre deposition and osteopontin immunoreactivity were markedly decreased in comparison with the control group. Royal jelly and alpha lipoic acid reversed the damage effect of glucocorticoid on the bone histological structure. Conclusion: Chronic use of glucocorticoid in adult male albino rats caused osteoporosis that could be reversed by administration of royal jelly and alpha lipoic acid.

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The inducing of caspase and Bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats

Cited by 10 publications

References 26 publications

Antitumor Activity of Royal Jelly and Its Cellular Mechanisms against Ehrlich Solid Tumor in Mice

Antitumor Activity of Royal Jelly and Its Cellular Mechanisms against Ehrlich Solid Tumor in Mice

The combined effect of eight-week resveratrol supplementation and interval training on some regulatory and executive factors of hepatocyte apoptosis in male rats with diabetes

The Possible Pre-emptive Role of Royal Jelly and Alpha Lipoic Acid on Osteoporosis Caused by Glucocorticoid in Adult Male Albino Rats

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