“…Diffuse lymphatic carcinomatous infiltration which produces secondary vascular thrombosis (Brill and Robertson, 1937) was reviewed by Harold (1952), but only one of this author's personal series of 24 cases showed terminal cardiac failure, and such a termination is rarely recorded (Greenspan, 1934;Krygier and Brill, 1942). Whilst lymphatic permeation has been noted frequently at necropsy since the time of Troisier (1873), it is only recently that the resulting disturbed physiology has become recognized as a cause of the clinical syndrome of alveolar-capillary block (Arnott, 1955). Many patients do not survive to reach this stage but post-mortem search often reveals widespread microscopic involvement (Harold, 1952;Willis, 1960).…”