Organic effects of associating paclitaxel with a lipid-based nanoparticle system on a nonhuman primate, &lt;em&gt;Cebus apella&lt;/em&gt;

Feio, Danielle Cristinne Azevedo; Oliveira, Nayara Cristina Lima de; Pereira, Elói; Morikawa, Aleksandra Tiemi; Muniz, José Augusto Pereira Carneiro; Montenegro, Raquel Carvalho; Alves, Ana Paula Negreiros Nunes; Lima, Patrícia Danielle Lima de; Maranhão, Raul C.; Burbano, Rommel Rodrı́guez

doi:10.2147/ijn.s129153

Cited by 10 publications

(1 citation statement)

References 42 publications

(44 reference statements)

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“…The anticancer action of PTX by stabilizing microtubules during mitosis, preventing the formation of spindle fiber and promoting Bcl-2 phosphorylation which leads to the arrest of the cell cycle, and induces tumor cell death (Alves et al, 2018). Despite its powerful antitumor activities, PTX produces severe side effects, including peripheral neuropathy (Park, 2014), inflammatory reaction, immunosuppression (Feio et al, 2017), cardiovascular toxicity (Malekinejad et al, 2016;Vassilakopoulou et al, 2010) and lung injury (Liu et al, 2015), which limit its efficacy. Antioxidant agents have been extensively used for the prevention of damage induced by oxidative stress (El-Sayed et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effects of propolis and coenzyme Q10 against short-term paclitaxel associated cardiopulmonary toxicity: histopathological and immunohistochemical evaluation.

Aly,

Almashed,

Tantawy

et al. 2023

Benha Veterinary Medical Journal

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This study aimed to assess the protective effects of Coenzyme Q10 (CoQ10) and propolis on paclitaxel (PTX)-induced cardiopulmonary toxicity. Thirty male albino rats were divided into six equal groups. Group I (control), group II (CoQ10), group III (propolis), group IV (PTX), group V (CoQ10+ PTX) and group VI (propolis+ PTX). Intraperitoneal injection of PTXinduced myocardial hyalinosis and necrosis associated with focal hemorrhages, swelling and damage of the endothelium lining the myocardial blood vessels with perivascular edema and mononuclear cells infiltration. Also, PTX significantly elevated serum CK-MB and LDH levels. Furthermore, PTX causes focal hemorrhage, perivascular edema, mononuclear cell infiltrations and fibrinoid necrotizing vasculitis in the lungs with hyperplasia and desquamation of the bronchiolar epithelium. Strong positive immunoreactivity of TNF-α and low expression of Bcl-2 were recorded in the heart and lungs of rats in the PTX group. Pretreatment with propolis or CoQ10 markedly improved the microscopic pictures of the heart and lungs confirmed by significantly mild immunoreaction of TNF-α and moderate expression of Bcl-2 in the hearts and lungs and reversed the elevated CK-MB and LDH levels. In conclusion, pretreatment with CoQ10 or propolis had a significant protective effect against PTX-induced cardiopulmonary toxicity through attenuation of proinflammatory cytokines and the apoptotic pathway.

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Section: Introductionmentioning

confidence: 99%

Ameliorative effects of propolis and coenzyme Q10 against short-term paclitaxel associated cardiopulmonary toxicity: histopathological and immunohistochemical evaluation.

Aly,

Almashed,

Tantawy

et al. 2023

Benha Veterinary Medical Journal

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Metagenomic assessment of the Cebus apella gut microbiota

Firrman

Liu

Tanes

et al. 2019

American J Primatol

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Cebus Apella (C. apella) is a species of Nonhuman Primate (NHP) used for biomedical research because it is phylogenetically similar and shares anatomical commonalities with humans. Here, the gut microbiota of three C. apella were examined in the different regions of the intestinal tract. Using metagenomics, the gut microbiota associated with the luminal content and mucus layer for each intestinal region was identified, and functionality was investigated by quantifying the levels of short chain fatty acids (SCFAs) produced. The results of this study show a high degree of similarity in the intestinal communities among C. apella subjects, with multiple shared characteristics. First, the communities in the lumen were more phylogenetically diverse and rich compared to the mucus layer communities throughout the entire intestinal tract. The small intestine communities in the lumen displayed a higher Shannon diversity index compared to the colon communities. Second, all the communities were dominated by aero-tolerant taxa such as Streptococcus, Enterococcus, Abiotrophia, and Lactobacillus, although there was preferential colonization of specific taxa observed. Finally, the primary SCFA produced throughout the intestinal tract was acetic acid, with some propionic acid and butyric acid detected in the colon regions. The small intestine microbiota produced significantly less SCFAs compared to the communities in the colon. Collectively, these data provide an in-depth report on the composition, distribution, and SCFA production of the gut microbiota along the intestinal tract of the C. apella NHP animal model. K E Y W O R D SCebus apella, gut microbiota, in vivo studies, intestinal tract, primate research, tufted capuchin

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Phase II study of paclitaxel associated with lipid core nanoparticles (LDE) as third-line treatment of patients with epithelial ovarian carcinoma

et al. 2017

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Ovarian cancer is often diagnosed at advanced stages, when poorly responsive to standard treatment. First-line treatment consists in schemes including cytoreductive surgery followed by adjuvant chemotherapy schemes with platinum and taxane derivatives. Second-line regimens are based on gemcitabine and liposomal doxorubicin. Third line is often not worthwhile because of the high toxicity with poor response to treatment. Previously, we showed that paclitaxel (PTX) carried in non-protein lipid core nanoparticles (LDE) resembling the chemical structure of LDL has remarkably reduced toxicity. Here, the hypothesis was tested whether PTX-LDE could safely benefit patients in third-line treatment setting. Fourteen women unresponsive to second-line chemotherapy for ovarian cancer, aged 61 ± 10 years, clinical stage IV and TqNqM1, were included. PTX-LDE was administered at 175 mg/m, 3/3 week dose. Patients were submitted to clinical examinations before each chemotherapy cycle. Serum biochemistry and imaging examinations to monitor disease progression were performed. In total, 74 cycles of chemotherapy were done and, in all cycles, clinical or laboratorial toxicities were not observed. Median progression-free survival (PFS) was 3.0 months (95% CI 2.0-3.9). In four patients, PFS was >6 months and in 2 > 1 year. The unpreceded, striking absence of toxicity and consistently long PFS, compared to previous results, indicate that at least 4 among 14 patients had tumor arrest by the treatment and clear benefit of PTX-LDE at third-line setting. The absence of observable toxicity allows dose escalating to improve response to treatment, as perspective to be tested in the ensuing studies.

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Organic effects of associating paclitaxel with a lipid-based nanoparticle system on a nonhuman primate, <em>Cebus apella</em>

Cited by 10 publications

References 42 publications

Ameliorative effects of propolis and coenzyme Q10 against short-term paclitaxel associated cardiopulmonary toxicity: histopathological and immunohistochemical evaluation.

Ameliorative effects of propolis and coenzyme Q10 against short-term paclitaxel associated cardiopulmonary toxicity: histopathological and immunohistochemical evaluation.

Metagenomic assessment of the Cebus apella gut microbiota

Phase II study of paclitaxel associated with lipid core nanoparticles (LDE) as third-line treatment of patients with epithelial ovarian carcinoma

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