Organic matrix-free imaging mass spectrometry

Kim, Eun Jin; Kim, Jisu; Choi, Inseong; Lee, Jeong-Wook; Yeo, Woon‐Seok

doi:10.5483/bmbrep.2020.53.7.078

Cited by 6 publications

(3 citation statements)

References 70 publications

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“…Therefore, it is necessary to develop novel methods to address these issues. Over the past decade, significant progress has been made in the application of nanomaterials in MALDI/MS . Carbon-based nanomaterials, noble metal nanoparticles, metal, metal oxides, metal–organic frameworks (MOFs), and organic covalent frameworks (COFs) have been successfully applied for the MALDI/MS analysis of small molecules. − When used as the MALDI/MS matrix, these nanomaterials minimize the spectral interference.…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Heterostructure-Assisted Laser Desorption Ionization Mass Spectrometry Analysis and Imaging of Quinolones

Wang,

Zhang,

Liang

et al. 2024

ACS Appl. Mater. Interfaces

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Quinolone residues resulting from body metabolism and waste discharge pose a significant threat to the ecological environment and to human health. Therefore, it is essential to monitor quinolone residues in the environment. Herein, an efficient and sensitive matrix-assisted laser desorption/ionization mass spectrometry (MALDI/MS) method was devised by using a novel molecularly imprinted heterojunction (MIP-TNs@GCNs) as the matrix. Molecularly imprinted titanium dioxide nanosheets (MIP-TNs) and graphene-like carbon nitrides (GCNs) were associated at the heterojunction interface, allowing for the specific, rapid, and high-throughput ionization of quinolones. The mechanism of MIP-TNs@GCNs was clarified using their adsorption properties and laser desorption/ionization capability. The prepared oxygen-vacancy-rich MIP-TNs@GCNs heterojunction exhibited higher light absorption and ionization efficiencies than TNs and GCNs. The good linearity (in the quinolone concentration range of 0.5−50 pg/ μL, R 2 > 0.99), low limit of detection (0.1 pg/μL), good reproducibility (n = 8, relative standard deviation [RSD] < 15%), and high salt and protein resistance for quinolones in groundwater samples were achieved using the established MIP-TNs@GCNs−MALDI/ MS method. Moreover, the spatial distributions of endogenous compounds (e.g., amino acids, organic acids, and flavonoids) and xenobiotic quinolones from Rhizoma Phragmitis and Rhizoma Nelumbinis were visualized using the MIP-TNs@GCNs film as the MALDI/MS imaging matrix. Because of its superior advantages, the MIP-TNs@GCNs−MALDI/MS method is promising for the analysis and imaging of quinolones and small molecules.

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Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Heterostructure-Assisted Laser Desorption Ionization Mass Spectrometry Analysis and Imaging of Quinolones

Wang,

Zhang,

Liang

et al. 2024

ACS Appl. Mater. Interfaces

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“…Various types of nanoparticles such as metallic, metal oxides, silicon-based, quantum dots, carbon-based, and porous nanoparticles have been successfully demonstrated as matrix. , Bimetallic MOF-NPs have improved physical and chemical characteristics as a result of the complementary nature of the two metals. Bimetallic MOF-NPs are fascinating materials that have a wide range of uses, such as gas adsorption, catalysis, energy storage, and luminescence sensing .…”

Section: Introductionmentioning

confidence: 99%

Bimetallic Metal–Organic Framework Nanoparticles for Monitoring Metabolic Changes in Cardiovascular Disorders

Rejeeth

Sharma

Kumar

et al. 2023

ACS Appl. Nano Mater.

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A group of disorders known as cardiovascular diseases (CVDs) affect the blood vessels that supply the heart muscle. CVDs are the leading global cause of death; however, the absence of a successful metabolomic strategy has impeded the advancement of CVD research. Because of this great challenge, bimetallic metal−organic framework (MOF) nanoparticles (NPs) have been developed for metabolic finger printings (MFs) in the study of molecular changes in CVD and coronary artery disease (CAD). A simple method for the design of various bimetallic MOF-NPs based on Zeolitic Imidazolate Frameworks (ZIFs) and bimetallic structure is reported. The serum MF was determined by examining 500 nL of natural serum in a few of seconds using the best bimetallic MOFs candidate (containing both Zn and Cu) integrated with assisted laser desorption/ionization mass spectrometry (LDI MS). Through the disclosed technology and a serum-based organization model, CVD patients could be differentiated from controls and CAD that have a sensitivity of 96% and a specificity of 93%. Furthermore, a portion of serum metabolic profiles with consistent changes can be used to track the progression of CVD, CAD, and controls. This study presents a state-of-the-art molecular approach for the metabolomic characterization of CVD and CAD that could one day be utilized to mimic clinical decisions in personalized therapy for cardiovascular disorders.

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“…FIGURE 4 | LDI MSI with organic matrix-free systems harnessing nanostructured surfaces or nanoparticles(Kim et al, 2020).…”

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confidence: 99%

Advances in MALDI Mass Spectrometry Imaging Single Cell and Tissues

Zhu

Chen

et al. 2022

Front. Chem.

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Compared with conventional optical microscopy techniques, mass spectrometry imaging (MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique, which can sensitively and simultaneously detect, quantify, and map hundreds of biomolecules, such as peptides, proteins, lipid, and other organic compounds in cells and tissues. So far, although several soft ionization techniques, such as desorption electrospray ionization (DESI) and secondary ion mass spectrometry (SIMS) have been used for imaging biomolecules, matrix-assisted laser desorption/ionization (MALDI) is still the most widespread MSI scanning method. Here, we aim to provide a comprehensive review of MALDI-MSI with an emphasis on its advances of the instrumentation, methods, application, and future directions in single cell and biological tissues.

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Organic matrix-free imaging mass spectrometry

Cited by 6 publications

References 70 publications

Molecularly Imprinted Heterostructure-Assisted Laser Desorption Ionization Mass Spectrometry Analysis and Imaging of Quinolones

Molecularly Imprinted Heterostructure-Assisted Laser Desorption Ionization Mass Spectrometry Analysis and Imaging of Quinolones

Bimetallic Metal–Organic Framework Nanoparticles for Monitoring Metabolic Changes in Cardiovascular Disorders

Advances in MALDI Mass Spectrometry Imaging Single Cell and Tissues

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