Organic optoelectronics for lab-on-chip fluorescence detection

Jahns, Sabrina; Iwers, Andre F. K.; Balke, Jan; Gerken, Martina

doi:10.1515/teme-2017-0034

Cited by 8 publications

(9 citation statements)

References 9 publications

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“…[160][161][162] Two main measurement principles have been employed for on-chip sensing with OLEDs: sample transmission/absorption [95,163,164] and detection of photoluminescence from a compound in the sample. [78,[164][165][166][167][168][169][170][171][172][173][174][175][176] Both modalities can be set up to record signals at different wavelengths and can multiplex several analytes in parallel, e.g., through the use of multiple microfluidic channels on a chip.…”

Section: Oleds For Lab-on-chip Applicationsmentioning

confidence: 99%

Emerging Biomedical Applications of Organic Light‐Emitting Diodes

Murawski

Gather

2021

Advanced Optical Materials

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As solid‐state light sources based on amorphous organic semiconductors, organic light‐emitting diodes (OLEDs) are widely used in modern smartphone displays and TVs. Due to the dramatic improvements in stability, efficiency, and brightness achieved over the last three decades, OLEDs have also become attractive light sources for compact and “imperceptible” biomedical devices that use light to probe, image, manipulate, or treat biological matter. The inherent mechanical flexibility of OLEDs and their compatibility with a wide range of substrates and geometries are of particular benefit in this context. Here, recent progress in the development and use of OLEDs for biomedical applications is reviewed. The specific requirements that this poses are described and compared to the current state of the art, in particular in terms of the brightness, patterning, stability, and encapsulation of OLEDs. Examples from several main areas are then discussed in some detail: on‐chip sensing and integration with microfluidics, wearable devices for optical monitoring, therapeutic devices, and the emerging use in neuroscience for targeted photostimulation via optogenetics. The review closes with a brief outlook on future avenues to scale the manufacturing of OLED‐based devices for biomedical use.

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Section: Oleds For Lab-on-chip Applicationsmentioning

confidence: 99%

Emerging Biomedical Applications of Organic Light‐Emitting Diodes

Murawski

Gather

2021

Advanced Optical Materials

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“…The proposed solution proved stability and high commercialization potential. Organic optoelectronics for building compact lab-on-a-chip applications was used by Jahns et al (2017) who introduced two devices. For the first device, four 5 mm 2 OLEDs and four 5 mm 2 OPDs were manufactured separately on two 25 × 25 mm 2 glass substrates.…”

Section: Organic Electronic-based Designsmentioning

confidence: 99%

Miniaturization of fluorescence sensing in optofluidic devices

Măriuța

Colin

Barrot-Lattes

et al. 2020

Microfluid Nanofluid

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Successful development of a micro-total-analysis system (µTAS, lab-on-a-chip) is strictly related to the degree of miniaturization, integration, autonomy, sensitivity, selectivity, and repeatability of its detector. Fluorescence sensing is an optical detection method used for a large variety of biological and chemical assays, and its full integration within lab-on-a-chip devices remains a challenge. Important achievements were reported during the last few years, including improvements of previously reported methodologies, as well as new integration strategies. However, a universal paradigm remains elusive. This review considers achievements in the field of fluorescence sensing miniaturization, starting from off-chip approaches, representing miniaturized versions of their lab counter-parts, continuing gradually with strategies that aim to fully integrate fluorescence detection on-chip, and reporting the results around integration strategies based on optical-fiber-based designs, optical layer integrated designs, CMOS-based fluorescence sensing, and organic electronics. Further successful development in this field would enable the implementation of sensing networks in specific environments that, when coupled to Internet-of-Things (IoT) and artificial intelligence (AI), could provide real-time data collection and, therefore, revolutionize fields like health, environmental, and industrial sensing.

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“…While very impressive results are achieved with the lamination of several ultraflexible substrates, this procedure is not easily upscaled for the parallel fabrication of many sensor units. We have previously demonstrated the integration of OLEDs and OPDs on single rigid substrates in a monolithic integration approach [6] and proposed a device configuration for fluorescence measurements [7]. Our long-term goal is the realization of a small, multiplexed sensor for point-of-need analysis.…”

Section: Introductionmentioning

confidence: 99%

OLED-OPD Matrix for Sensing on a Single Flexible Substrate

et al. 2020

Self Cite

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Integration of organic light emitting diodes (OLEDs) and organic photodetectors (OPDs) on flexible plastic substrates promises compact and low-cost optical detection units for multiplex sensors. These units may be laminated to a microfluidic system for sensing applications in a liquid. Here, a 6 × 6 element matrix of alternating blue OLEDs and OPDs is demonstrated on a single flexible plastic substrate. The devices are fabricated by masked thermal evaporation on a 200 µm thick polyethylene terephthalate (PET) foil. The individual device size is 1 mm × 1 mm. Both OLEDs and OPDs are demonstrated to work. The spectral characteristics are shown to be suitable for fluorescence measurements. Signals from fluorescence-labeled spots above the OPDs under OLED excitation are investigated. Successful operation of the OLED-OPD matrix for reflection measurement is demonstrated.

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Organic optoelectronics for lab-on-chip fluorescence detection

Abstract: We present two designs of organic optoelectronics for compact lab-on-chip fluorescence detection. In the first configuration, organic light emitting diode (OLED) and organic photo diode (OPD) are fabricated

Cited by 8 publications

References 9 publications

Emerging Biomedical Applications of Organic Light‐Emitting Diodes

Emerging Biomedical Applications of Organic Light‐Emitting Diodes

Miniaturization of fluorescence sensing in optofluidic devices

OLED-OPD Matrix for Sensing on a Single Flexible Substrate

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