Organo-bridged silsesquioxane incorporated mesoporous silica as a carrier for the controlled delivery of ibuprofen and fluorouracil

Rehman, Fozia; Kettab, Ahmed; Rahim, Abdur; Muhammad, Nawshad; Tariq, Sarah; Azhar, Usaid; Khan, Asif Jamal; Sama, Zaib us; Volpe, Pedro L. O.; Airoldi, Cláudio

doi:10.1016/j.molliq.2018.03.057

Cited by 49 publications

(42 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reported slow release properties of the synthetic EXK/CF as a carrier for the OL drug might be ascribed to the expected formation of strong hydrogen bonds between the active functional groups of the drug and the siloxane groups of exfoliated kaolinite that became highly reactive after the exfoliation processes. 25 It was reported that the release profiles that exhibit continuous and slow diffusion properties are of promising effect during the treatment of the cancer cell. This was related to the constant exposure of the cancer cells to the released drug molecules, inducing the inhibition of the proliferation of the target cancer cells.…”

Section: Resultsmentioning

confidence: 99%

Insight into the Loading and Release Properties of an Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrier for Oxaliplatin Drug: Cytotoxicity and Release Kinetics

et al. 2020

View full text Add to dashboard Cite

Kaolinite layers were exfoliated as single sheets and admixed with cellulose fibers, forming an advanced exfoliated kaolinite/cellulose fiber (EXK/CF) composite, which was characterized as a promising carrier for the oxaliplatin (OL) drug to induce safety as well as the therapeutic effect. The EXK/CF composite exhibited promising loading capacity and achieved an experimental value of 670 mg/g and an expected theoretical value of 704.4 mg/g. The loading behavior of OL using the EXK/CF composite followed the pseudo-first-order kinetic model and the Langmuir equilibrium model, achieving an adsorption energy of 7.7 kJ/mol. This suggested physisorption and homogeneous loading behavior of the OL molecules in a monolayer form. The release profile of OL from EXK/CF continued for about 100 h with maximum release percentages of 86.4 and 95.2% in the phosphate and acetate buffers, respectively. The determined diffusion exponent from the Korsmeyer–Peppas kinetic model suggested non-Fickian transport behavior of the OL molecules and releasing behavior controlled by erosion as well as diffusion mechanisms. Regarding the cytotoxic effect, the EXK/CF composite has a high safety impact on the normal colorectal cells (CCD-18Co) and higher toxic impacts on the colorectal cancer cell (HCT116) than the free oxaliplatin drug.

show abstract

Section: Resultsmentioning

confidence: 99%

Insight into the Loading and Release Properties of an Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrier for Oxaliplatin Drug: Cytotoxicity and Release Kinetics

et al. 2020

View full text Add to dashboard Cite

show abstract

“…where Q t is a fraction of the famotidine released at t (time), Q 0 is the initial amount of famotidine, K 0 , K 1 , K KP , K HC , and K H F I G U R E 1 Schematic of synthesis of grafting 3-aminophenol on modified ZnS and drug loading. ZnS, zinc sulphide are the kinetic constants, and n is the value of the diffusion exponent characteristic of the famotidine-release mechanism [24].…”

Section: Kinetic Modelling Of Famotidine Releasementioning

confidence: 99%

Design of 3‐aminophenol‐grafted polymer‐modified zinc sulphide nanoparticles as drug delivery system

Abniki

Azizi

Panahi

2021

IET Nanobiotechnology

View full text Add to dashboard Cite

Zinc sulphide (ZnS) nanoparticles were synthesized by the coprecipitation method. The ZnS nanoparticle surface was polymerized with allyl glycidyl ether (AGE), and 3aminophenol was then deposited as a ligand on nanosorbent. The modified nanosorbent was investigated with Fourier transform infrared spectroscopy and thermogravimetric analysis. The particle size of the modified nanosorbent was studied with scanning electron microscopy. Some characteristic factors of the adsorption process such as pH and time were investigated for famotidine using the modified nanosorbent. The equilibrium adsorption study of famotidine by 3-aminophenol-grafted AGE/ZnS was analysed by adsorption isotherms of the Langmuir, Freundlich, and Temkin models. The famotidine-releasing process was investigated in simulated biological fluids (intestinal fluid at pH of 7.4 and gastric fluid at pH of 1.2) and demonstrated 65% and 73% famotidine release during periods of 30 h (pH = 7.4) and 60 min (pH = 1.2), respectively. These results reveal the optimal performance of 3-aminophenol-grafted AGE/ZnS for sustained drug delivery.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

“…[16][17][18] Ibuprofen is a recognized analgesic and antiinflammatory drug. 19 Currently, the drug usually enters the body by oral administration. 20,21 However, its poor water solubility results in poor bioavailability of high oral doses.…”

Section: Introductionmentioning

confidence: 99%

“…Ibuprofen is a recognized analgesic and anti‐inflammatory drug 19 . Currently, the drug usually enters the body by oral administration 20,21 .…”

Section: Introductionmentioning

confidence: 99%

Sustained‐release ibuprofen prodrug particle: Emulsifier and initiator regulate the diameter and distribution

Wang

Zhang

Qian

et al. 2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

Polymers have played a vital part in the development of drug delivery systems (DDS). For DDS, having a controllable diameter and distribution are conducive to reproducibility of drug release behavior and efficacy. In this work, an ibuprofen prodrug (Ibu@PMMA) was synthesized by methyl methacrylate (MMA), ibuprofen monomer (Ibu@HEMA), and ethylene glycol dimethacrylate (EGDMA) via emulsion polymerization. The Ibu@PMMA exhibits spherical shapes, and its structural properties were characterized by NMR, FTIR, and SEM techniques. In addition, the hydrodynamic diameter and polydispersity index (PDI) of Ibu@PMMA were reduced by increasing the proportion of emulsifier. Meanwhile, by increasing the amount of initiator, the hydrodynamic diameter and PDI of Ibu@PMMA were decreased. Moreover, Ibu@PMMA exhibits good sustainedrelease ability in vitro, which could be used as a potential delivery system for antiinflammatory agents.

show abstract

Organo-bridged silsesquioxane incorporated mesoporous silica as a carrier for the controlled delivery of ibuprofen and fluorouracil

Cited by 49 publications

References 50 publications

Insight into the Loading and Release Properties of an Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrier for Oxaliplatin Drug: Cytotoxicity and Release Kinetics

Insight into the Loading and Release Properties of an Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrier for Oxaliplatin Drug: Cytotoxicity and Release Kinetics

Design of 3‐aminophenol‐grafted polymer‐modified zinc sulphide nanoparticles as drug delivery system

Sustained‐release ibuprofen prodrug particle: Emulsifier and initiator regulate the diameter and distribution

Contact Info

Product

Resources

About