Organobismuthines Containing Aromatic Heterocycles: Synthesis and Charcterization

Lemus, Adela; Sharma, Pankaj; Cabrera, Armando; Rosas, N.; Álvarez, C.; Gómez, Elizabeth; Sharma, Manoj; Céspedes, Carlos L.; Hernández, Santiago Cortés

doi:10.1515/mgmc.2001.24.12.835

Cited by 8 publications

(9 citation statements)

References 9 publications

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“…2-thienyl-stibine and -bismuthine. 12,13 In stibine 5, the average Sb-C bond distance is 2.121(3)Å; to the best of our knowledge, this is the shortest Sb-C distance reported so far for compounds of this type. This may be due to the electronegativity of chlorine atoms present in the ring and pπ -dπ bonding between antimony and the carbon atom of the ring.…”

Section: Methodsmentioning

confidence: 66%

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Substituted thienyl stibines and bismuthines: syntheses, structures and cytotoxicity

Sharma¹,

Rosas²,

Cabrera³

et al. 2005

Appl. Organometal. Chem.

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New stibine and bismuthine substituted thienyl ring compounds, i.e. tris(3-methyl-2-thienyl)stibine (1), tris(3-methyl-2-thienyl)bismuthine (2), tris(3-thienyl)stibine (3), tris(3-thienyl)bismuthine (4) and tris(5-chloro-2-thienyl)stibine (5), have been synthesized and characterized by IR, mass, 1 H, 13 C, COSY, and HETCOR NMR spectroscopy. The metal centres in all compounds are pyramidal, and molecules in the stibine compound (1) and bismuthine compound (2) associate via Sb· · ·S or Bi· · ·S interactions to form supramolecular chains.The cytotoxicity of compounds 1 and 5 was determined. For compound 5, 85% of carcinogenic cell growth inhibition (U, K and H) was observed. Compound 1 shows a significant selectivity (>80%) for carcinogenic cell growth (K and U) inhibition. Both the compounds are highly toxic for the growth of normal lymphocytes with ∼95% lethality. Compound 1 is approximately 20 times more toxic than 5 against Artemia salina.

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Section: Methodsmentioning

confidence: 66%

“…At ambient temperature, four 13 C NMR signals were observed for these compounds in the aromatic region. In bismuthine, most of the protons are deshielded in comparison with stibines; similar observations were also reported earlier.…”

Section: Main Group Metal Compoundsmentioning

confidence: 99%

Substituted thienyl stibines and bismuthines: syntheses, structures and cytotoxicity

Sharma¹,

Rosas²,

Cabrera³

et al. 2005

Appl. Organometal. Chem.

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“…On the basis of the structures of other tertiary stibines and bismuthines containing C-heterocyclic ring [5,6], a pyramidal structure may be assigned to (1) and (2). Stibine (C 4 H 3 Se) 3 Sb (1) is pyramidal.…”

Section: Resultsmentioning

confidence: 99%

“…1 H and 13 C NMR spectra were recorded in CDCl 3 or CD 3 OD on JEOL ECLIPSE 300 ( 1 H: 300.5311 MHz; 13 C: 75.5757 31 P{ 1 H}: 121 MHz) spectrometer. The cytotoxicity experiments against carcinogenic cells [37] leukaemia K562, CNS U251 and colon cancer HCT15 and toxicity experiments against Artemia Salina [6] were carried out as reported earlier by our group.…”

Section: Methodsmentioning

confidence: 99%

“…Recently our group have reported some new stibines and bismuthines containing C-attached 2-thienyl, 2-furyl and 2-(N-methylpyrrolyl) group. X-ray structures and biological activities of these stibines and bismuthines have also been reported [5][6][7]. On the other hand, selenophen-2-yl substituted derivative of p-block metals/metalloids are very rare in literature, which is evident from the fact that a framework (including any metal-selenophenyl, benzoselenophenyl and their g-complexes) generates only 97 entries through a search of the Science Finder.…”

Section: Introductionmentioning

confidence: 99%

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