Organogels as Matrices for Controlled Drug Delivery: A Review on the Current State

Sagiri, Sai S.; Behera, Beauty; Rafanan, Ruby; Bhattacharya, C.; Pal, Kunal; Banerjee, Indranil; Rousseau, De ́rick

doi:10.1080/1539445x.2012.756016

Cited by 118 publications

(74 citation statements)

References 307 publications

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“…Physical encapsulation of an API effectively forms a multi-component gel 6 -the drug may form direct interactions with the gelator, or be passively adsorbed within the gel matrix. Organogels based on pharmaceutically relevant oils can be used for API formulation, 7 for example Naproxen salts form organogels capable of controlled API release. 8 However, hydrogels offer potentially greater biocompatibility.…”

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confidence: 99%

Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

2015

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confidence: 99%

Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

2015

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“…These types of gels consist of two parts, gelling agent (network forming) and liquid solvent phase (hydrophilic or hydrophobic). However, depending on the polarity of the liquid immobilized within the networked structure, gels may be termed either as hydro gels (polar solvent-water) or organogels (organic solvent) [1]. An organ gel can be defined as an organic liquid entrapped within a thermo-reversible, anhydrous and structured viscous-elastic material by a three-dimensional gel network, also referred to as oleo gels if the organic phase is edible oil.…”

Section: Introductionmentioning

confidence: 99%

Organogelation: It’s Food Application

Kaushik

Jain

et al. 2017

MOJFPT

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There is growing evidence that dietary fat may linked to risk of a number of chronic disorders, such as coronary heart disease or type 2 diabetes. Due to increasing consumer awareness to healthy and risk of saturated fat, food manufacturers are switching on novel technologies. One of novel technology is organogelation/oleogelation i.e. structuring of edible oils. The unique physical, functional, and nutritional properties of edible oil organogels has caught the eye of the food and pharmaceutical industries. These organogels are formed upon self assembly of surfactant-like small molecules into crystalline fibers at very low concentrations (wt 2%), which could be exploited for a variety of purposes in food products, from the manufacture of spreads to the solubilization, stabilization and delivery of lipid-soluble nutraceuticals. The use of oleo gels in the food industry is still in its infancy, but the potential is significant. This paper reviews about the traditional and current strategies of structuring oleo gels, types of gelators used in structuring and food applications.

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“…Low-molecular-weight organogelators (LMOG), which are able to self-assembled form gels (organogels) with organic solvents, have been extensively studied in recent decades due to their potential wide applications in industrial fields, such as cosmetics, foods, medical engineering, and drug delivery (Vintiloiu & Leroux, 2008;Pandey et al, 2010;Basak et al, 2012;Jiao et al, 2012b;Balata et al, 2013;Sagiri et al, 2014). The growth of LMOG units usually result in the formation of various supramolecular polymers, such as fibers, ribbons, and sheets as a result of hydrogen bonding, van der Waals (hydrophobic) and -stacking interactions (Florent et al, 2010;Jiao et al, 2013;Guo et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Self-assembled drug delivery system based on low-molecular-weight bis-amide organogelator: synthesis, properties and in vivo evaluation

Cao

et al. 2016

Drug Delivery

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(2016) Self-assembled drug delivery system based on low-molecular-weight bisamide organogelator: synthesis, properties and invivo evaluation, Drug Delivery, 23:8, 3168-3178, DOI: 10.3109/10717544.2016 RESEARCH ARTICLESelf-assembled drug delivery system based on low-molecular-weight bis-amide organogelator: synthesis, properties and in vivo evaluation Zhen Li, Jinxu Cao, Heran Li, Hongzhuo Liu, Fei Han, Zhenyun Liu, Chao Tong, and Sanming Li School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, P.R. China Abstract Context: Orgnaogels based on amino acid derivatives have been widely used in the area of drug delivery. Objective: An organogel system based on L-lysine derivatives was designed and prepared to induce a thermal sensitive implant with higher transition temperature, better mechanical strength, and shorter gelation time. Materials and methods: The organogel was prepared by injectable soybean oil and methyl (S)-2,5-ditetradecanamidopentanoate (MDP), which was synthesized for the first time. Candesartan cilexetil (CC) was chosen as model drug. Different formulations were designed and optimized by response surface method. Thermal, rheology properties, and gelation kinetics of the optimized formulation had been characterized. The release behaviors in vitro, as well as in vivo were evaluated in comparison with the oily solution of drugs. Finally, the local inflammation response of in situ organogel was assessed by histological analysis. Results and discussion: Results showed that the synthesized gelator, MDP, had a good gelation ability and the organogels obtained via the self-assembly of gelators in vegetable oils exhibited great thermal and rheology properties, which guaranteed their state in body. In vivo pharmacokinetic demonstrated that the organogel formulation could extend the drug release and maintain a therapeutically effective plasma concentration at least 10 d. In addition, this implant showed acceptable moderate inflammation. Conclusion: The in situ forming L-lysine-derivative-based organogel could be a promising matrix for sustained drug delivery of the drugs with low solubility. KeywordsBiocompatibility, gelator, in situ implant system, in vivo release, organogel History

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Organogels as Matrices for Controlled Drug Delivery: A Review on the Current State

Cited by 118 publications

References 307 publications

Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

Organogelation: It’s Food Application

Self-assembled drug delivery system based on low-molecular-weight bis-amide organogelator: synthesis, properties and in vivo evaluation

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