Organoid-Transplant Model Systems to Study the Effects of Obesity on the Pancreatic Carcinogenesis in vivo

Lupo, Fabio; Piro, Geny; Torroni, Lorena; Delfino, Pietro; Trovato, Rosalinda; Rusev, Borislav; Fiore, Alessandra; Filippini, Dea; Sanctis, Francesco De; Manfredi, Marcello; Marengo, Emílio; Lawlor, Rita T.; Martini, Maurizio; Ugel, Stefano; Corbo, Vincenzo; Melisi, Davide; Carbone, Carmine

doi:10.3389/fcell.2020.00308

Cited by 10 publications

(9 citation statements)

References 67 publications

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“…In addition to the implementation of the most innovative “omics” techniques, the ability to develop predictable, reproducible, and reliable preclinical study models is an essential tool to accelerate the successful incorporation of Precision Medicine into mainstream clinical practice. In the oncology field, for instance, the evolution of research technologies has led to the generation of genetically engineered animal models spontaneously developing tumors, patient-derived xenografts and humanized immune-avatar models in which host immune system is replaced by patient’s cells [ 2 , 3 , 4 , 5 , 6 ]. Thus, precision animal modeling is the link between individualized care in human and advances in animal technologies and genetic manipulation.…”

Section: Introductionmentioning

confidence: 99%

Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go

Marchiano

Sante

Piro

et al. 2021

JPM

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The advent of Precision Medicine has globally revolutionized the approach of translational research suggesting a patient-centric vision with therapeutic choices driven by the identification of specific predictive biomarkers of response to avoid ineffective therapies and reduce adverse effects. The spread of “multi-omics” analysis and the use of sensors, together with the ability to acquire clinical, behavioral, and environmental information on a large scale, will allow the digitization of the state of health or disease of each person, and the creation of a global health management system capable of generating real-time knowledge and new opportunities for prevention and therapy in the individual person (high-definition medicine). Real world data-based translational applications represent a promising alternative to the traditional evidence-based medicine (EBM) approaches that are based on the use of randomized clinical trials to test the selected hypothesis. Multi-modality data integration is necessary for example in precision oncology where an Avatar interface allows several simulations in order to define the best therapeutic scheme for each cancer patient.

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Section: Introductionmentioning

confidence: 99%

Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go

Marchiano

Sante

Piro

et al. 2021

JPM

Self Cite

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“…Increasing age is a risk factor for the incidence and mortality of PAAD, while PAAD is more frequent in males than in females [2]. Smoking cigarettes, obesity, heavy alcohol abuse and family history are known risk factors for PAAD patients [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Increasing age is a risk factor for the incidence and mortality of PAAD, while PAAD is more frequent in males than in females 2 . Smoking cigarettes, obesity, heavy alcohol abuse and family history are known risk factors for PAAD patients 3 - 5 . Smoking cigarettes can alter the microenvironment of pancreatic tissue, lead to long-standing inflammation, increase onco-miRNA expression, induce KRAS mutations and affect enzyme secretion 6 .…”

Section: Introductionmentioning

confidence: 99%

Integrate analysis of the promote function of Cell division cycle-associated protein family to pancreatic adenocarcinoma

Chen¹,

Wang²,

Zhu³

et al. 2021

Int. J. Med. Sci.

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“…Organoids maintain the in vivo characteristics of pre-neoplastic cells and are able to progress into invasive tumors following orthotopic transplantation in syngeneic hosts [ 24 , 83 ]. Murine organoids generated from either preinvasive or neoplastic pancreases have been injected into diabetic mice and have shown, in vivo, that the diabetic microenvironment promotes PDAC progression [ 88 ]. Orthotopic syngeneic transplant models assist with studying the role of immune cell infiltration as lesions progress from preinvasive to metastatic disease [ 24 ], which is not possible in immune incompetent patient derived xenografts.…”

Section: Preclinical Models Of Pancreatic Ductal Adenocarcinomamentioning

confidence: 99%

The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids

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Lim

Nguyen

et al. 2021

Cancers

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Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies. While immortalized cancer cell lines and genetically engineered murine models have increased our understanding of PDAC tumorigenesis, they do not recapitulate inter- and intra-patient heterogeneity. PDAC patient derived organoid (PDO) biobanks have overcome this hurdle, and provide an opportunity for the high throughput screening of potential new therapies. This review provides a summary of the PDAC PDO biobanks established to date, and discusses how they have advanced our understanding of PDAC biology. Looking forward, the development of coculturing techniques for specific immune or stromal cell populations will enable a better understanding of the crosstalk that occurs within the tumor microenvironment, and the impact of this crosstalk on treatment response.

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Organoid-Transplant Model Systems to Study the Effects of Obesity on the Pancreatic Carcinogenesis in vivo

Cited by 10 publications

References 67 publications

Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go

Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go

Integrate analysis of the promote function of Cell division cycle-associated protein family to pancreatic adenocarcinoma

The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids

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