An overview is given of physics differences between stellarators and tokamaks, including magnetohydrodynamic equilibrium, stability, fast-ion physics, plasma rotation, neoclassical and turbulent transport, and edge physics. Regarding microinstabilities, it is shown that the ordinary, collisionless trapped-electron mode is stable in large parts of parameter space in stellarators that have been designed so that the parallel adiabatic invariant decreases with radius. Also, the first global, electromagnetic, gyrokinetic stability calculations done for Wendelstein 7-X suggest that kinetic ballooning modes are more stable than in a typical tokamak.