ORIGINAL ARTICLE Journal of Evolution of Medical and Dental Sciences/ Volume 2/ Issue 37/ September 16, 2013 Page 7120 ENDOMETRIAL THICKNESS AND PREGNANCY OUTCOME IN IUI CYCLES

Abstract

OBJECTIVES: To investigate whether endometrial thickness on the day of hCG administration is a predictor of intrauterine insemination (IUI) success. MATERIAL AND METHODS: Three hundred and eighty women undergoing IUI cycles are analysed for Endometrial thickness on the day of hCG administration, Endometrial thickness measurement was done on the day of HCG administration. Correlation between endometrial thickness and factors such as age, dominant follicle numbers, stimulation protocols and pregnancy rate were assessed& compared between pregnant and non pregnant patients. A similar comparison was made between ongoing pregnancies and those that resulted in a loss in a University hospital-based infertility center from Dec 2011-Nov 2012. Main Outcome Measure(s): Endometrial thickness versus IUI outcome. RESULTS: In 220 couples, 365 cycles performed. Pregnancy rate was 14.5%. 90% of pregnancies were ongoing. The mean age of females was 28.6 & mean ET was 8.1mm +-1.47. The mean ET in age range 17-25 yrs was 7.4±1.98 mm and in age range of >40 years was 6.9±1.7 mm (p=0<001HS). With increasing the number of 16-18 mm follicles pregnancy rate was 16%, 11% &15.6% with 1,2 & >3 follicles . No statistically significant correlation was found between the two. INTRODUCTION:To obtain a higher likelihood of achieving pregnancy, IUI is usually synchronized with ovulation, either in a natural or a stimulated cycle. The overall success of IUI varies, with pregnancy rates between 5 and 26% per cycle (1). During ovulatory cycles, pattern and thickness of endometrial is variable. After menstruation, endometrium is thin and becomes thicker gradually. Although many studies were done about affecting factors on endometrial thickness in infertile women, over the years, but the results is still unclear ( 2 ,3).The aim of this study was to determine the effect of some factors such as age, number of follicles on the endometrial thickness and its impact on pregnancy in intrauterine insemination cycles. OBJECTIVE:To discover the factors contributing to endometrial thickness, and to assess the impact of endometrial thickness on pregnancy rates (PRs) according to these factors. MATERIAL &METHODS:In this study we have evaluated a total of 365 IUI cycles at SMS Medical College Jaipur (Dec 2011 to Nov 2012 infertile women considered for intrauterine insemination (IUI). Endometrial thickness measurement was done on the day of HCG administration. Cycles were natural/stimulated with letrozole 5 clomiphene citrate and/or gonadotrophins (HMG/FSH). Letroz5 50-100 mg clomiphene citrate (D3-D7), followed by 75-150 IU of gonadotrophins added Correlation between endometrial thickness and factors such as age, total follicle number and pregnancy rate were assessed. Ovarian (Follicle maturation) and endometrial responses monitored by serial TVS D9-13. 5000-10000 IU HCG administered (when at least one follicle mean diameter was >18 mm. On the day of hCG administration, TVS scan measure endometrial thickness &

Factors Influencing the Pregnancy Outcome of Intrauterine Insemination and Follow-Up Treatment

“…EMT and classification can be used as an index to evaluate endometrial receptivity. A large number of studies have shown that the pregnancy outcome is affected by the EMT on the day of IUI performance,[ 5 26 ] and the clinical pregnancy rate was highest when EMT was between 8 and 12 mm. [ 16 ] One retrospective research that assessed 1065 IUI cycles indicated that when the EMT was <7 mm or more than 14 mm, the clinical pregnancy rate was lower than the thickness between 7 and 14 mm.…”