Mesoproterozoic crust is widely exposed in the Grenville Province portion of northeastern Laurentia, where it is interpreted as an assemblage of two continental-arc segments separated by a composite arc belt (Quebecia) with island-arc remnants. A synthesis of the geologic context, types, and geochemical patterns of 1.5–1.35 Ga granitoids reveals a regional distribution in each segment, with dioritic to granitic plutonism variably associated with arc-related volcano-sedimentary belts in the south and inboard monzonitic to granitic plutonism in the north. In addition, belts of dioritic to granitic orthogneisses occupy intermediate positions in Quebecia and in the west. The inboard granites are consistently old in all segments (1.5–1.45 Ga), but the preserved volcano-sedimentary belts are older in the east and in Quebecia (1.5–1.45 Ga) and younger in the west (1.39? and 1.36 Ga), while the belts of orthogneisses show a large spread of ages at 1.45–1.37 Ga. Granitoids in the volcano-sedimentary belts and the orthogneisses include magnesian, calcic to calc-alkalic components to ferroan, alkali-calcic components. In contrast, the inboard plutons are dominantly ferroan and alkali-calcic to alkalic in the continental-arc segments, where they are locally associated with anorthosite-mangerite-charnockite-granite (AMCG) suites. Collectively, the different types of granitoid magmatism can be linked to an active margin, with subduction under northeastern Laurentia, involving arc building, arc rifting, back-arc opening and inboard extension, and amalgamation processes variably operating at different parts of the margin and at different times. In addition, the data provide a basis for comparison with other parts of the eastern to southwestern Laurentian margin in the 1.5–1.35 Ga time frame.