Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice

Huang, Hongjuan; Cai, Hengji; Zhang, Li; Hua, Zhixiang; Shi, Jian; Wei, Yuegang

doi:10.1016/j.intimp.2019.106123

Cited by 22 publications

(9 citation statements)

References 35 publications

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“…Gao et al [51] discovered in their study of Long noncoding RNAs (lncRNAs) that SHCBP1 served as a tumor promoter and was lowly expressed in non-small cell lung cancer. The results of the work of Huang et al [52] inferred that inhibition of SHCBP1 to achieve lower levels of inflammatory factors may be part of the mechanism why lignocaine A can be used against skin cancer. Our work laid the cornerstone for further identifying SHCBP1 as a therapeutic target and biomarker in its capacity as a tumor-promoting factor.…”

Section: Discussionmentioning

confidence: 99%

SHCBP1: A Novel Potential Molecular Target for Pan- Cancer Therapy

Xin¹,

Wang²,

Li³

et al. 2022

NDSI

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Purpose: Although many experimentally validated evidence and clinical data support the link between SHCBP1 (SHC-Binding and Spindle-Associated 1) and cancer, there is no pan-cancer analysis available. Based on various databases, we analyzed the roles assumed by SHCBP1 in different cancers to provide new targets for cancer therapy. Methods: We used versatile public databases such as TIMER, Interactive Analysis of Gene Expression Profile, 2nd Edition (GEPIA), UALCAN, The Cancer Genome Atlas (TCGA), cBioPortal, Clinical Bioinformatics Assistant, DiseaseMeth, TISIDB, Human Protein Atlas (HPA), STRING and Database for Annotation, Visualization, and Integrated Discovery (DAVID) to analyze SHCBP1 expression, mutation, methylation in tumors, as well as its survival analysis, tumor-immune interactions and functional networks. Results: SHCBP1 was highly expressed in most tumors leading to poor prognosis and the degree of expression was positively correlated with the degree of infiltration by activated memory CD4+ T cells. We observed cancer-associated fibroblast infiltration in Breast Invasive Carcinoma (BRCA), Renal Clear Cell Carcinoma (KIRC) and Thyroid Cancer (THCA). Protein kinase activity and microtubules can influence gene enrichment, while "cell cycle", "oocyte meiosis" and "viral carcinogenesis" are possible pathways of SHCBP1 involvement in tumorigenesis. Conclusion: Altogether, our first pan-cancer analysis of SHCBP1 demonstrated its potential as a biomarker for tumor prognosis diagnosis or as a molecular target for immunotherapy.

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Section: Discussionmentioning

confidence: 99%

SHCBP1: A Novel Potential Molecular Target for Pan- Cancer Therapy

Xin¹,

Wang²,

Li³

et al. 2022

NDSI

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“…Besides, OA has shown promising effects against skin cancer progression. In a recent study, OA was shown to decrease the inflammatory factors and hyperplasia via the suppression of NF-κB signaling and SHC SH2 domain-binding protein 1 (SHCBP1) in skin cancer in vitro and in vivo models [ 137 ]. In addition, fruitful results have been obtained from studies using OA against cervical cancer, which is one of the major causes of cancer deaths in women around the world.…”

Section: Oa For Cancermentioning

confidence: 99%

Oroxylin A: A Promising Flavonoid for Prevention and Treatment of Chronic Diseases

et al. 2022

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There have been magnificent advancements in the understanding of molecular mechanisms of chronic diseases over the past several years, but these diseases continue to be a considerable cause of death worldwide. Most of the approved medications available for the prevention and treatment of these diseases target only a single gene/protein/pathway and are known to cause severe side effects and are less effective than they are anticipated. Consequently, the development of finer therapeutics that outshine the existing ones is far-reaching. Natural compounds have enormous applications in curbing several disastrous and fatal diseases. Oroxylin A (OA) is a flavonoid obtained from the plants Oroxylum indicum, Scutellaria baicalensis, and S. lateriflora, which have distinctive pharmacological properties. OA modulates the important signaling pathways, including NF-κB, MAPK, ERK1/2, Wnt/β-catenin, PTEN/PI3K/Akt, and signaling molecules, such as TNF-α, TGF-ꞵ, MMPs, VEGF, interleukins, Bcl-2, caspases, HIF-1α, EMT proteins, Nrf-2, etc., which play a pivotal role in the molecular mechanism of chronic diseases. Overwhelming pieces of evidence expound on the anti-inflammatory, anti-bacterial, anti-viral, and anti-cancer potentials of this flavonoid, which makes it an engrossing compound for research. Numerous preclinical and clinical studies also displayed the promising potential of OA against cancer, cardiovascular diseases, inflammation, neurological disorders, rheumatoid arthritis, osteoarthritis, etc. Therefore, the current review focuses on delineating the role of OA in combating different chronic diseases and highlighting the intrinsic molecular mechanisms of its action.

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“…Baicalin inhibited cell proliferation, arrested the cell cycle at the G0/G1 phase, and induced cell death through caspase 3/7 activation [ 96 ]. Oroxylin A could down-regulate the expression of SHCBP1 (it is an oncogene involved in the development of various cancers) to inhibit the carcinogen-induced malignant transformation of JB6 P + skin epidermal cells and decrease the number of tumor cells [ 97 ].…”

Section: Pharmacological Effects (Shown In Table 2 mentioning

confidence: 99%

Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review

et al. 2020

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Scutellaria baicalensis Georgi. (SB) is a common heat-clearing medicine in traditional Chinese medicine (TCM). It has been used for thousands of years in China and its neighboring countries. Clinically, it is mostly used to treat diseases such as cold and cough. SB has different harvesting periods and processed products for different clinical symptoms. Botanical researches proved that SB included in the Chinese Pharmacopoeia (1st, 2020) was consistent with the medicinal SB described in ancient books. Modern phytochemical analysis had found that SB contains hundreds of active ingredients, of which flavonoids are its major components. These chemical components are the material basis for SB to exert pharmacological effects. Pharmacological studies had shown that SB has a wide range of pharmacological activities such as antiinflammatory, antibacterial, antiviral, anticancer, liver protection, etc. The active ingredients of SB were mostly distributed in liver and kidney, and couldn't be absorbed into brain via oral absorption. SB’s toxicity was mostly manifested in liver fibrosis and allergic reactions, mainly caused by baicalin. The non-medicinal application prospects of SB were broad, such as antibacterial plastics, UV-resistant silk, animal feed, etc. In response to the Coronavirus Disease In 2019 (COVID-19), based on the network pharmacology research, SB’s active ingredients may have potential therapeutic effects, such as baicalin and baicalein. Therefore, the exact therapeutic effects are still need to be determined in clinical trials. SB has been reviewed in the past 2 years, but the content of these articles were not comprehensive and accurate. In view of the above, we made a comprehensive overview of the research progress of SB, and expect to provide ideas for the follow-up study of SB.

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Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice

Cited by 22 publications

References 35 publications

SHCBP1: A Novel Potential Molecular Target for Pan- Cancer Therapy

SHCBP1: A Novel Potential Molecular Target for Pan- Cancer Therapy

Oroxylin A: A Promising Flavonoid for Prevention and Treatment of Chronic Diseases

Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review

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