Osmotic-Driven Release Kinetics of Bioactive Therapeutic Proteins from a Biodegradable Elastomer are Linear, Constant, Similar, and Adjustable

Abstract

The elastomer formulation shows promising potential as a sustained protein drug delivery vehicle for local delivery applications.

Controlled Release of IGF-1 and HGF from a Biodegradable Polyurethane Scaffold

“…Biodegradable thermoset elastomers based on ε-caprolactone and D,L-lactide have been processed with solid drug particles to form an osmotically-driven drug delivery device that delivers drug in a zero-order fashion. (18, 36, 37) The release rates in this system can be altered by changing the molecular weight of the prepolymer or the amount of excipient included with the drug. In another report ascorbic acid was incorporated into the backbone of a thermoplastic polyurethane and released only after hydrolysis of ester bonds.…”

Photo-irradiation paradigm: Mapping a remarkable facile technique used for advanced drug, gene and cell delivery

“…They were broadly used as biodegradable implant for the following features they own: the exhibition of mechanical properties being as soft as body tissues make them attractive for the implantation in the highly challenging non static parts of the body; their elasticity can be utilized along with osmotic potential to generate linear release profiles for water soluble compounds in proteins/peptides delivery [112,140]. In addition, the availability of tuning the mechanical and biodegradation characteristics through the selection of appropriate photo-crosslinkable precursors.…”

“…Lifetimes of such biosorbable implants could be adapted by adjusting the molecular weight, degree of crystallinity and crosslinking density of the engineered photo-cured matrices [112]. Moreover, the photo-irradiated elastomers with precisely engineered building units and friendly formulation conditions exemplify ideal carriers for viable cells encapsulation [21,38] and prolonged delivery of cytokines [91,140,141] (Tables 3 and 6). There are many PRP that had been implied to prepare bioelastomers such as peptide conjugated acryloyl polyethylene glycol [21], cinnamated poly(glycerol sebacate) [29,62], methacrylated star poly(ε-caprolactone-co-D,L-lactide) [142], poly(ε-caprolactone-cotrimethylene carbonate) [143], poly(ε-caprolactone) end-functionalized with maleic or itaconic anhydride [144], poly(ε-caprolactone) chain extended with 4,4(adipoyldioxy) dicinnamic acid [145], and poly(ε-caprolactone) combined with poly ethyl acrylate [146].…”

“…For example, Younes et al used photo-crosslinked bioelastomeric implants for bioactive protein delivery in localized cancer immunotherapy [112]. Biodegradable elastomeric matrices loaded with interferon-γ, vascular endothelial growth factor and IL-2 have been investigated and reported lately for their suitability as sustained release carrier [112,140]. These devices were formulated through UV-irradiation of an acrylated star poly(ε-caprolactone-co-D,L-lactide).…”

Zero-order controlled release of ciprofloxacin-HCl from a reservoir-based, bioresorbable and elastomeric device

“…Elastomeric properties also provide greater utility in device implantation for such techniques as catheterization or biopsy injection. Devices constructed from biodegradable elastomers have also been demonstrated to achieve sustained drug release [20,21]. These studies report on a reputed osmotic driven flux from drug embedded in a matrix of new biodegradable elastomer based on a photocrosslinked acrylated star copolymer macromer of ε-caprolactone and D,L lactide.…”