Osmotic water permeability of aquaporin-1 under radial tensile and compressive stimuli

Bahari, Shaghayegh; Davarnejad, Reza; Bavi, Omid; Mohammadi, Seyed Vahid

doi:10.1016/j.desal.2020.114524

Cited by 5 publications

(2 citation statements)

References 74 publications

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“…Although α w and α 0 do not influence the cell when it reaches a steady state, it has a significant impact on the transient osmolarity. It has also been found that the water permeability can depend on membrane tension (Ozu et al, 2013 ; Bahari et al, 2020 ). With this consideration, the transient time scale will be different, i.e., the cell will reach a steady state either faster or slower depends on whether the cell expands or shrinks.…”

Section: Resultsmentioning

confidence: 99%

Hydrogen, Bicarbonate, and Their Associated Exchangers in Cell Volume Regulation

Zhou

Sun

2021

Front. Cell Dev. Biol.

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Cells lacking a stiff cell wall, e.g., mammalian cells, must actively regulate their volume to maintain proper cell function. On the time scale that protein production is negligible, water flow in and out of the cell determines the cell volume variation. Water flux follows hydraulic and osmotic gradients; the latter is generated by various ion channels, transporters, and pumps in the cell membrane. Compared to the widely studied roles of sodium, potassium, and chloride in cell volume regulation, the effects of proton and bicarbonate are less understood. In this work, we use mathematical models to analyze how proton and bicarbonate, combined with sodium, potassium, chloride, and buffer species, regulate cell volume upon inhibition of ion channels, transporters, and pumps. The model includes several common, widely expressed ion transporters and focuses on obtaining generic outcomes. Results show that the intracellular osmolarity remains almost constant before and after cell volume change. The steady-state cell volume does not depend on water permeability. In addition, to ensure the stability of cell volume and ion concentrations, cells need to develop redundant mechanisms to maintain homeostasis, i.e., multiple ion channels or transporters are involved in the flux of the same ion species. These results provide insights for molecular mechanisms of cell volume regulation with additional implications for water-driven cell migration.

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Section: Resultsmentioning

confidence: 99%

Hydrogen, Bicarbonate, and Their Associated Exchangers in Cell Volume Regulation

Zhou

Sun

2021

Front. Cell Dev. Biol.

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“…This has only been possible though when the external force was applied to the parts of the channel that has a key role in the gating process and a robust elastic range in response to external force before they unfold. As the gating mechanism of these channels becomes discovered, the root is being paved for the use of these channels as tunable nanovalves in smart drug delivery systems, as well as some novel applications in water filtration, desalination process, and biomolecules sequencing [41] , [42] .…”

Section: Introductionmentioning

confidence: 99%