Osseoinductive elements around immediate implants for better osteointegration: a pilot study in foxhound dogs

Salomó-Coll, Oscar; Maté‐Sánchez, José‐Eduardo; Ramírez-Fernández, María Piedad; Hernández–Alfaro, Federico; Gargallo‐Albiol, Jordi; Calvo-Guirado, José Luís

doi:10.1111/clr.12809

Cited by 14 publications

(11 citation statements)

References 46 publications

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“…117 Similar results were reported in mice with chronic kidney disease (CKD), suggesting that vitamin D treatment may be an effective approach for implant placement in patients with CKD. 124 Recently, the effect of topical application of vitamin D (10%) 125 and melatonin (5%) 126 solutions on the surface of immediate implants placed in dogs was evaluated. Both topical applications improved significantly new bone formation around implants and reduced crestal bone loss at 12 weeks following surgery, 126 standing out the positive correlation between vitamin D and early stages of osseointegration.…”

Section: Cholesterol and Fatty Acidsmentioning

confidence: 99%

“…124 Recently, the effect of topical application of vitamin D (10%) 125 and melatonin (5%) 126 solutions on the surface of immediate implants placed in dogs was evaluated. Both topical applications improved significantly new bone formation around implants and reduced crestal bone loss at 12 weeks following surgery, 126 standing out the positive correlation between vitamin D and early stages of osseointegration. Therefore, these results may suggest that vitamin D has a protective effect on bone healing after implant insertion.…”

Section: Cholesterol and Fatty Acidsmentioning

confidence: 99%

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Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Ínsua

Monje

Wang

et al. 2017

J Biomedical Materials Res

195

188

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Despite the growing number of publications in the field of implant dentistry, there are limited studies to date investigating the biology and metabolism of bone healing around dental implants and their implications in peri-implant marginal bone loss. The aim of this review article is to provide a thorough understanding of the biological events taking place during osseointegration and the subsequent early and late phases of bone remodeling around dental implants. An update on the coupling mechanism occurring during bone resorption-bone remodeling is provided, focused on the relevance of the osteocytes, bone lining cells and immune cells during bone maintenance. An electronic and manual literature search was conducted by three independent reviewers in several databases, including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register databases for articles up to September 2016 with no language restriction. Local bone metabolism is subject to signals from systemic calcium-phosphate homeostasis and bone remodeling. Three areas of interest were reviewed due to recent reported compromises in bone healing including the putative effects of (1) cholesterol, (2) hyperlipidemia, and (3) low vitamin D intake. Moreover, the prominent influence of osteocytes and immune cells is discussed as being key regulators during dental implant osseointegration and maintenance. These cells are of crucial importance in the presence of biofilm accumulation and their associated byproducts that leads to hard and soft tissue breakdown; the so called peri-implantitis. Factors that could negatively impact osteoclastogenesis or osteal macrophage activation should be monitored in future research including implant placement/torque protocols, bone characteristics, as well as meticulous maintenance programs to favor osseointegration and future long-term stability and success of dental implants. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2075-2089, 2017.

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Section: Cholesterol and Fatty Acidsmentioning

confidence: 99%

Section: Cholesterol and Fatty Acidsmentioning

confidence: 99%

Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Ínsua

Monje

Wang

et al. 2017

J Biomedical Materials Res

195

188

View full text Add to dashboard Cite

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“…Absence of melatonin or its inefficient production affects people who work on night shift, undergo changes in time zone, and suffer from insomnia 16 . In addition, melatonin interferes with bone healing in several ways: through modulation of inflammatory process, collagen fibril formation, osteoblast differentiation, and oxidative stress 6 , 9 , 10 , 15 , 26 , 28 .…”

Section: Introductionmentioning

confidence: 99%

Daily melatonin administration improves osseointegration in pinealectomized rats

et al. 2018

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The hypothesis of this study was that the peri-implant bone healing of the group of pinealectomized rats would differ from the control group. The samples were subjected to immunohistochemical, microtomographic (total porosity and connectivity density), and fluorochrome (mineralized surface) analyses. Objectives The goal of this study was to investigate the cellular changes and bone remodeling dynamics along the bone/implant interface in pinealectomized rats.Material and Methods The total of 18 adult male rats (Rattus norvegicus albinus, Wistar) was divided into three groups (n=6): control (CO), pinealectomized without melatonin (PNX) and pinealectomized with melatonin (PNXm). All animals were submitted to the first surgery (pinealectomy), except the CO group. Thirty days after the pinealectomy without melatonin, the second surgery was conducted, in which all animals received an implant in each tibia (36 titanium implants with surface treatment were installed – Implalife® São Paulo, SP, Brazil). By gavage, the rats of the PNX group received the vehicle solution, and the procedure.Results Immunohistochemical analysis for runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP), osteopontin (OP) and osteocalcin (OC) showed that the bone repair process in the PNXm group was similar to that of the CO group, whereas the PNX group showed a delay. The microtomographic parameters of total porosity [Po(tot)] and bone surface (BS) showed no statistically significant differences, whereas for the connective density (Conn.Dn) a statistical difference was found between the CO and PNXm groups. Fluorochrome analysis of the active mineralized surface showed statistically significant difference between the CO and PNX and between the CO and PNXm groups.Conclusion The absence of the pineal gland impaired the bone repair process during osseointegration, however the daily melatonin replacement was able to restore this response.

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“…Both topical applications improved new bone formation around implants significantly and reduced crestal bone loss at 12 weeks following surgery, indicating the positive correlation between vitamin D and early stages of osseointegration. 18 Aydın et al 19 reported a significant increase in the amount of vitamin D in propolis groups and stated that the healing of the implanted bone was improved.…”

Section: Resultsmentioning

confidence: 99%

“…The study was conducted on patients aged 18 Panoramic radiographs were taken with the same device (Veraviewpocs 2D, Morita, Japan) and with the same technical parameters (64-66 kVp; 6-9 mA; 10 s and voxel size 0.08 mm 3 ). Klemetti et al 7 defined MCI as C1, C2, C3 according to the visibility of the mandibular cortical bone.…”

Section: Methodsmentioning

confidence: 99%

The Relationship Between the Mandibular Bone Quality Assessed by Digital Panoramic Radiography and Serum Biological Parameters in Patients Planning Dental Implant Surgery

Orhan

Özemre

Yilmaz

et al. 2020

Cumhuriyet Dental Journal

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The aim of this study was to evaluate the bone density of the implant site with panoramic radiomorphometric parameters [mandibular cortical index (MCI), mental index (MI)], and to investigate the relationships between bone density, vitamin D, HDL, and LDL. Materials and Methods: Forty patients with mandibular first molar or second molar tooth deficiency who had undergone implant surgery were included in the study. Blood samples and panoramic MCI and MI parameters were used to evaluate mandibular bone density. Data were analyzed using the Mann-Whitney U and Kruskal-Wallis tests. The relationships between MI and the study variables were assessed by Spearman's correlation coefficient. The Chi-square or Fisher's exact tests were used to determine the relationships between MCI and the study variables. p< 0.05 was considered statistically significant. Results: There were significant weak positive correlationsof MI with Vitamin D and LDL (r = 0.329, p = 0.038; r = 0.341, p = 0.031). Vitamin D, LDL, and HDL measurements were not statistically different among the MCI groups (p=0.100, p=0.119, p=0.840, respectively). Conclusions: Vitamin D level may carry importance in addition to radiographic and clinical parameters; thus, patients should be evaluated in this respect. Further studies involvinglarger patient groups are needed to conclude the relationship between vitamin D level and bone quality.

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Osseoinductive elements around immediate implants for better osteointegration: a pilot study in foxhound dogs

Abstract: Within the limitations of this animal study, topical applications of 5% Melatonin or 10% vitamin D improved bone formation around implants placed immediately after extraction and helped to reduce CBL after 12 weeks osseointegration.

Cited by 14 publications

References 46 publications

Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Daily melatonin administration improves osseointegration in pinealectomized rats

The Relationship Between the Mandibular Bone Quality Assessed by Digital Panoramic Radiography and Serum Biological Parameters in Patients Planning Dental Implant Surgery

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