Osseointegration of macroporous calcium phosphate ceramics having a different chemical composition

Frayssinet, Patrick; Trouillet, J.L.; Rouquet, Nicole; Azimus, E.; Autefage, A.

doi:10.1016/0142-9612(93)90144-q

Cited by 169 publications

(88 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To exclude the possibility that results might be influenced by fibre length great care was taken during the cutting of PEEK samples to ensure that the disc were of identical size. Topographical features in the micrometer range can affect activation, adhesion, orientation, morphology and movement of cells and the expression of genes [8]. It has already been considered that not only the chemical properties and the chemical composition, but also the physical quality of a biomaterial surface affects cell-biomaterial interactions by influencing the attachment and subsequent modulation of the intracellular signals that are involved [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…This has resulted in discussion that calcium phosphate compounds might not have a favorable effect on bone growth. It is very difficult to find a common cause for the inhibition of cell proliferation by calcium phosphates, because the diversity of the specifications of the calcium phosphates makes it difficult to link the biological results obtained with the characteristics of the material [8,15]. The mitochondrial cell activity during the total assay was not blocked, showing that bTCP-PEEK do not induce cytotoxicity but inhibit the cell proliferation under the chosen study conditions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of βTCP filled polyetheretherketone on osteoblast cell proliferation in vitro

Petrovic

Pohle²,

Münstedt³

et al. 2005

J Biomed Sci

View full text Add to dashboard Cite

SummaryNon-resorbable thermoplastic polymers have become more important for reconstructive surgery due to their excellent chemical and physical properties. Polyetheretherketone-b-tricalcium phosphate (bTCP-PEEK) composites were developed as alternative materials for load-bearing applications. This study presents the effect of polyetheretherketone (PEEK) specimens incorporated with 5, 10, 20 and 40 wt% b-tricalcium phosphate (bTCP) and processed by injection molding on cultivated osteoblast cells. Normal human osteoblast (NHOst) cells were seeded onto polymer discs to evaluate cell viability and proliferation after 24, 72 and 120 h of cultivation by employing the WST-1 assay. Standard tissue culture plastic was used as a control. The osteoblast cells were found to be viable in all PEEK groups, while the cell proliferation was progressively inhibited due to the incorporated b-tricalcium phosphate. bTCP-PEEK showed concentration independent decrease of cell proliferation compared to the unfilled PEEK and the control group. In summary, this study confirms the non-toxic nature of pure PEEK, whereas this could not definitely be verified for bTCP-PEEK as a composite material in chosen concentrations of b-tricalcium phosphate in vitro.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of βTCP filled polyetheretherketone on osteoblast cell proliferation in vitro

Petrovic

Pohle²,

Münstedt³

et al. 2005

J Biomed Sci

View full text Add to dashboard Cite

show abstract

“…Moreover, the use of a partially resorbable calcium phosphate ceramic encourages faster bone formation at the expense of ceramic crystals [10]. CPC have been demonstrated to bond to bone tissue under specific conditions, including close contact between the graft and host, and the achievement of primary stability.…”

Section: Discussionmentioning

confidence: 99%

“…The CPC, regardless of the composition (HA or TCP), are biocompatible and physicochemically bound to the host bone [10]. Oonishi et al [22] showed that bone stock restoration was regularly achieved in acetabular reconstruction with impacted HA granules during revision total hip replacement.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bone substitution in revision hip replacement

Nich

Sedel

2006

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

Effects of calcium phosphate bioceramics on skeletal muscle cells

Sun

Tsuang

Yao

et al. 1997

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

With advances in ceramics technology, calcium phosphate bioceramics have been applied as bone substitutes. The effects of implants on bony tissue have been investigated. The effects upon adjacent skeletal muscles have not been determined. The focus of this work is to elucidate the biological effects of various calcium phosphate bioceramics on skeletal muscles. Four different kinds of powder of calcium phosphate biomaterials including beta-tricalcium phosphate (beta-TCP), hydroxyapatite (HA), beta-dicalcium pyrophosphate (beta-DCP) and sintered beta-dicalcium pyrophosphate (SDCP), were tested by myoblast cell cultures. The results were analyzed by cell count, cell morphology and concentration of transforming growth factor beta 1 (TGF-beta 1) in culture medium. The cell population and TGF-beta 1 concentration of the control sample increased persistently as the time of culture increased. The changes in cell population and TGF-beta 1 concentration in culture medium of the beta-TCP and HA were quite low in the first 3 days of culture, then increased gradually toward the seventh day. The changes in cell population and TGF-beta 1 concentration in culture medium of the silica, beta-DCP, and SDCP were quite similar. They were lower during the first day of culture but increased and reached that of the control medium after 7 days' culture. Most cells on B-TCP and HA diminished in size with radially spread, long pseudopods. We conclude that HA and beta-TCP are thought to have an inhibitory effect on growth of the myoblasts. The HA and beta-TCP may interfere with the repair and regeneration of injured skeletal muscle after orthopedic surgery.

show abstract

Osseointegration of macroporous calcium phosphate ceramics having a different chemical composition

Cited by 169 publications

References 12 publications

Effect of βTCP filled polyetheretherketone on osteoblast cell proliferation in vitro

Effect of βTCP filled polyetheretherketone on osteoblast cell proliferation in vitro

Bone substitution in revision hip replacement

Effects of calcium phosphate bioceramics on skeletal muscle cells

Contact Info

Product

Resources

About