Osseous metaplasia in ovarian papillary serous cystadenocarcinoma

Bosscher, James; Barnhill, Danny; O’Connor, Dennis M.; Doering, David L.; Nash, John D.; Park, Robert

doi:10.1016/0090-8258(90)90439-r

Cited by 24 publications

(21 citation statements)

References 4 publications

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“…In contrast to calcified ovarian fibromas (5-8) and osseous metaplasia (1,(9)(10)(11), which are relatively common, only three cases of primary ovarian osteoma have been reported. Several pathophysiological hypotheses have been proposed.…”

Section: Discussionmentioning

confidence: 80%

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Aspects of an ovarian osteoma on magnetic resonance imaging and computerized tomography

Ballester

Bazot

Daraı̈

2008

Fertility and Sterility

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Section: Discussionmentioning

confidence: 80%

“…Ovarian osteomas are very rare, contrary to other ovarian tumors like teratomas and mixed mesodermal tumors with bony components (1). At present, only three histologically confirmed cases have been described (2)(3)(4).…”

mentioning

confidence: 98%

Aspects of an ovarian osteoma on magnetic resonance imaging and computerized tomography

Ballester

Bazot

Daraı̈

2008

Fertility and Sterility

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“…It might be difficult to distinguish calcification from ossification exactly. Some papers have reported the causes of ossification [6][7][8][9][10][11][12][13][14][15][16]. Here, we would like to discuss why ossification, i.e., massive calcification, occurred.…”

Section: Discussionmentioning

confidence: 94%

“…Ossification is a phenomenon in which some tissues are uniquely differentiated or morphologically altered, or a morphological change is noted in adjacent tissue. The following four causes have been considered as reasons for ossification [11][12][13][14]: (a) degenerative necrosis, (b) replacement of cartilage, (c) skeletal muscle-related cause, and (d) epithelial ossification not related to calcification or cartilage [15]; (d) may be the mechanism underlying tumor ossification, in which bone marrow stromal cells might stimulate certain factors to cause tumors not related to calcification, or cartilage to differentiate into bone. Bone morphogenetic protein (BMP-2), transforming growth factor (TGF)-b, and fibroblast growth factor (FGF)-2 have been suggested to be among such factors by Kim et al [16].…”

Section: Discussionmentioning

confidence: 99%

A case of pancreatic solid-pseudopapillary neoplasm with marked ossification

Tajima

Kawaguchi

Ito

et al. 2011

Clin J Gastroenterol

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A cystic lesion of the pancreas was detected in a 25-year-old asymptomatic woman during a company medical checkup. Abdominal computed tomography (CT) revealed an ossified lesion in the pancreatic body, and the patient was referred to us for further management. Abdominal ultrasound and endoscopic ultrasound showed a hypoechoic mass with a large ossific focus, measuring 25 mm in the pancreatic body. CT and magnetic resonance imaging (MRI) showed a nonenhancing tumor lesion with a large calcific focus, measuring 20 mm in the pancreatic body. Endoscopic retrograde pancreatography revealed mild stenosis of the main pancreatic duct near the ossific focus in the pancreatic body. From the above, a pancreatic solid-pseudopapillary neoplasm (SPN) was suspected, and resection of the pancreatic body was performed. Intraoperatively, a whitish tumor measuring about 20 mm was recognized. Histopathologically, moderately large-sized tumor cells containing eosinophilic cytoplasm were arranged in a pseudopapillary formation, and infiltrated the surrounding normal tissue with ossification. Immunostaining was positive for α1-antitrypsin, not inconsistent with the diagnosis of SPN. We report this case of pancreatic SPN with ossification and a review of the literature.

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“…In cases like this one, occasional neoplastic cells must be sought in order to exclude tumors such as a serous borderline or malignant tumor with confluent psammoma bodies [4] and a gonadoblastoma replaced by laminated calcified masses, but with evidence of abnormal gonadal development. Also ossification of an ovary is extremely rare and usually associated with ovarian cystic teratoma [5], mucinous cystadenoma [5], papillary serous cystadenocarcinoma [6], endometrioid adenocarcinoma [7], thecoma [8], and endometriosis [9]. In fact, a common manifestation of ovarian endometriosis is cystification resulting in an endometriotic cyst.…”

Section: Discussionmentioning

confidence: 97%

Bilateral massive osseous metaplasia in ovaries: “ovarian stones”

Lanzafame

Nicolosi²,

Caltabiano

2006

Gynecol Surg

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We report a case of bilateral ovarian ossifications with images that mimic stone formations. A 65-year-old woman presented with a 2-year history of pelvic pain. Computed tomographic scan and pelvic ultrasound identified an enlarged uterus with two calcified lesions interpreted as leiomyomas. Surgical exploration revealed two ovaries with a cystic appearance and stony hard areas. The cyst contents consisted of chocolate-colored material. The pathologic findings were compatible with benign bilateral ovarian endometriotic cysts with extensive ossification. The pelvic pain resolved completely after the surgery. Though the cause of this rare case remains unknown, recognition of cysts with a content of chocolate-colored material and pigment-laden histiocytes allowed us to make the diagnosis of bilateral ovarian endometriotic cysts with extensive ossification. Complete excision was the treatment of choice.

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Osseous metaplasia in ovarian papillary serous cystadenocarcinoma

Cited by 24 publications

References 4 publications

Aspects of an ovarian osteoma on magnetic resonance imaging and computerized tomography

Aspects of an ovarian osteoma on magnetic resonance imaging and computerized tomography

A case of pancreatic solid-pseudopapillary neoplasm with marked ossification

Bilateral massive osseous metaplasia in ovaries: “ovarian stones”

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