Osseous metaplasia with functioning bone marrow in hydroxyapatite orbital implants

Abstract

Background: Bone formation within the hydroxyapatite implant has been reported in explanted spheres in humans. Bone-specific differentiation was observed to occur earlier in the pores of spherical hydroxyapatite implants enhanced with osteogenin within the rabbit socket. We observed previously unreported bone marrow formation in a coralline hydroxyapatite implant placed into the rabbit orbit after evisceration. Methods: One eye of each of 10 New Zealand white rabbits weighing between 2 and 3 kg was eviscerated and implanted with hydroxyapatite spheres. The explanted hydroxyapatite spheres 20 weeks after surgery were examined under the microscope. Results: Histopathologic examination of the excised implants showed the presence of trabeculae of mature bone with fatty marrow and hematopoietic elements. Scattered throughout the fatty tissue were bone marrow elements consisting of precursors of the granulocytic and erythroid series and also megakaryocytes. Conclusion: The osseous metaplasia with functioning bone marrow was incidentally observed in the coralline hydroxyapatite implant without the addition of any osteogenesis-inducing agents.

Accuracy and Security Analysis of a Cranio-Maxillofacial Plastic Surgery Robot Equipped With Piezosurgery in Genioplasty

“…The clinical success of this technique might be attributed to the proliferative potential of the palatal periosteal connective tissue, as it is well known that adipose-rich connective tissue displays huge tendency to metaplasia. 27…”

“…The clinical success of this technique might be attributed to the proliferative potential of the palatal periosteal connective tissue, as it is well known that adipose-rich connective tissue displays huge tendency to metaplasia. 27 This surgical approach might be at risk for hemorrhage due to the lesion of the greater palatine or its smaller branches. The position of the greater palatine foramen has to be located before starting the surgery, and great attention should be paid to the reflection of the split thickness flap for the exposure of the palatal connective flap.…”