Ossification of a Collagen Membrane Cross‐Linked by Sugar: A Human Case Series

Abstract

GLYM maintained its barrier effect in five of seven cases for 25 weeks and induced dense new bone along its interface with underlying tissues. To the best of our knowledge, this is the first report on GLYM ossification in humans with direct mineral apposition on glycated collagen and suggests a new concept of tissue-integrated active barriers.

Ridge preservation procedures revisited: A randomized controlled trial to evaluate dimensional changes with two different surgical protocols

“…Additionally, Zubery et al. found evidence of membrane ossification when glycine cross‐linked membranes were used in osseous regeneration surgery . Direct apposition of bone along the side of the barrier and the ossification of the membrane itself may support the hard tissue findings seen in our study.…”

Histologic Comparison of Healing Following Tooth Extraction With Ridge Preservation Using Two Different Xenograft Protocols

“…The use of two different membranes introduces an additional variable to be considered; however, the use of each membrane was selected based on the specific properties of the materials used and the lack of intended primary closure over the site. The long‐resorbing OP membrane was placed over the XGS material to contain it during initial healing stages and enabled longer soft tissue exclusion to allow adequate time for osteoprogenitor cells to reach the site and initiate vital bone formation 13,14,23 . It is unknown if the selection of different membranes for the two protocols had an impact on clinical or histologic results; however, the results are similar to other studies in which rapidly resorbing collagen membranes were used to cover the graft material within the socket 17,18,24 …”

“…Primary closure over this material is recommended; however, if primary closure is not intended or obtained, a collagen membrane can be placed over the material to stabilize the initial blood clot and contain the bone graft substitute 9,10 . A resorbable collagen membrane composed of tendon‐derived type I porcine collagen cross‐linked by natural ribose glycation (OP) § can be used to occlude gingival cells from downgrowth into extraction sites 12‐14 . Another xenograft protocol that has been suggested for ridge preservation is 90% anorganic bovine bone with 10% porcine collagen fibers (ABBC) ‖ combined with a resorbable bilayer membrane composed of non‐cross‐linked porcine types I and III collagen (BG) ¶ 15…”

Randomized controlled trial on lateral augmentation using two collagen membranes: morphometric results on mineralized tissue compound

“…The history of premature membrane exposure may have a negative effect on new bone formation even if soft tissue dehiscence recovers by secondary epithelization. Although ribose-cross linked membranes might be associated with a higher incidence rate of soft tissue dehiscences (Moses et al, 2005;Tal, et al, 2008), the frequency of concomitant inflammatory reactions reported is almost zero (Friedmann et al, 2001 (Zubery, et al, 2007;Zubery et al, 2008).…”