Both membranes were safe and effective in supporting bone regeneration in critical size alveolar ridge defects in dogs and completely degraded within 24 weeks with marked BCM inconsistency. In areas of direct contact with bone, all GLYM sites were progressively ossified with time and augmented the original alveolar ridge. To the best of our knowledge, this is the first report of complete ossification of a collagen barrier membrane in GBR procedures.

GLYM maintained its barrier effect in five of seven cases for 25 weeks and induced dense new bone along its interface with underlying tissues. To the best of our knowledge, this is the first report on GLYM ossification in humans with direct mineral apposition on glycated collagen and suggests a new concept of tissue-integrated active barriers.

Ribose-cross-linked collagen is endowed with a higher functional longevity as assessed in an animal model when compared with the most used collagen-based dermal fillers.

Compared with several hyaluronic acid-based dermal fillers, Dermicol-P35 exhibited lower extrusion force, higher viscosity under low shear rate, and a higher modulus of elasticity. Results of histologic evaluation indicated that Dermicol-P35 27G did not elicit an inflammatory response and was well integrated within the host tissue. Together, these results suggest that Dermicol-P35 27G offers several advantages that may result in improved clinical experiences for both patients and clinicians.