Ossification of a Novel Cross‐Linked Porcine Collagen Barrier in Guided Bone Regeneration in Dogs

Abstract

Both membranes were safe and effective in supporting bone regeneration in critical size alveolar ridge defects in dogs and completely degraded within 24 weeks with marked BCM inconsistency. In areas of direct contact with bone, all GLYM sites were progressively ossified with time and augmented the original alveolar ridge. To the best of our knowledge, this is the first report of complete ossification of a collagen barrier membrane in GBR procedures.

Histomorphometric assessment of bone formation in sinus augmentation utilizing a combination of autogenous and hydroxyapatite/biphasic tricalcium phosphate graft materials: at 6 and 9 months in humans

“…The presence of an underlying osseous layer, just under the membrane has also been reported when non-resorbable membranes were examined histologically (Ohnishi et al 2000). Close histologic observation has also shown that a calcification process might occur in these remnants (Tal et al 2008;Zubery et al 2007). …”

Randomized controlled trial on lateral augmentation using two collagen membranes: morphometric results on mineralized tissue compound

“…The history of premature membrane exposure may have a negative effect on new bone formation even if soft tissue dehiscence recovers by secondary epithelization. Although ribose-cross linked membranes might be associated with a higher incidence rate of soft tissue dehiscences (Moses et al, 2005;Tal, et al, 2008), the frequency of concomitant inflammatory reactions reported is almost zero (Friedmann et al, 2001 (Zubery, et al, 2007;Zubery et al, 2008).…”

Effect of a Collagen Membrane Combined With a Porous Titanium Membrane on Exophytic New Bone Formation in a Rabbit Calvarial Model

“…Several collagen cross‐linking methods have been suggested, such as ultraviolet light, hexamethylene diisocyanate, glutaraldehyde plus irradiation, and diphenylphosphorylazide 34 . Recently, the collagen membranes cross‐linked using glycation showed a prolonged barrier function that led to increased bone regeneration when compared with other collagen membranes 42,43 . Therefore, additional studies will be needed to determine the effects of combining various types of cross‐linked membranes with a porous TM on new bone formation in terms of the barrier durability and cell occlusiveness.…”