OSTEMER polymer as a rapid packaging of electronics and microfluidic system on PCB

Fissi, Lamia El; Fernandez, Roman; Bou-Belda, Eva; Calero, María; García, José Manuel Miralles; Jiménez, Yolanda; Arnau, Antonio; Francis, Laurent

doi:10.1016/j.sna.2018.11.050

Cited by 10 publications

(8 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Mercene Labs AB, developed family of products under the trade name OSTEMER [ 104 ] specifically for microfluidics, lab-on-chip assembly and organ-on-a-chip [ 105 ]. OSTEMER epoxy-based resins are supposed to overcome the main drawbacks of PDMS, namely contamination and low adhesion, while being applied by casting in a very similar way to the PDMS process.…”

Section: Materials Considerationmentioning

confidence: 99%

Device Processing Challenges for Miniaturized Sensing Systems Targeting Biological Fluids

Stoukatch

Dupont

Redouté

2022

Biomedical Materials & Devices

View full text Add to dashboard Cite

This article presents a review of device processing technologies used in the fabrication of biomedical systems, and highlights the requirements of advanced manufacturing technology. We focus on biomedical systems that perform diagnostics of fluidic specimens, with analytes that are in the liquid phase. In the introduction, we define biomedical systems as well as their versatile applications and the essential current trends. The paper gives an overview of the most important biomolecules that typically must be detected or analyzed in several applications. The paper is structured as follows. First, the conventional architecture and construction of a biosensing system is introduced. We provide an overview of the most common biosensing methods that are currently used for the detection of biomolecules and its analysis. We present an overview of reported biochips, and explain the technology of biofunctionalization and detection principles, including their corresponding advantages and disadvantages. Next, we introduce microfluidics as a method for delivery of the specimen to the biochip sensing area. A special focus lies on material requirements and on manufacturing technology for fabricating microfluidic systems, both for niche and mass-scale production segments. We formulate requirements and constraints for integrating the biochips and microfluidic systems. The possible impacts of the conventional microassembly techniques and processing methods on the entire biomedical system and its specific parts are also described. On that basis, we explain the need for alternative microassembly technologies to enable the integration of biochips and microfluidic systems into fully functional systems.

show abstract

Section: Materials Considerationmentioning

confidence: 99%

Device Processing Challenges for Miniaturized Sensing Systems Targeting Biological Fluids

Stoukatch

Dupont

Redouté

2022

Biomedical Materials & Devices

View full text Add to dashboard Cite

show abstract

“…The same syringe was used for delivering glucose samples in a lab-on-PCB for electrochemical glucose sensing (2020) [ 38 ]. Finally, peristaltic micropumps have also been used as external impulsion for lab-on-PCBs [ 39 ].…”

Section: External Energy Systemsmentioning

confidence: 99%

Lab-on-PCB and Flow Driving: A Critical Review

Perdigones

2021

Micromachines

View full text Add to dashboard Cite

Lab-on-PCB devices have been developed for many biomedical and biochemical applications. However, much work has to be done towards commercial applications. Even so, the research on devices of this kind is rapidly increasing. The reason for this lies in the great potential of lab-on-PCB devices to provide marketable devices. This review describes the active flow driving methods for lab-on-PCB devices, while commenting on their main characteristics. Among others, the methods described are the typical external impulsion devices, that is, syringe or peristaltic pumps; pressurized microchambers for precise displacement of liquid samples; electrowetting on dielectrics; and electroosmotic and phase-change-based flow driving, to name a few. In general, there is not a perfect method because all of them have drawbacks. The main problems with regard to marketable devices are the complex fabrication processes, the integration of many materials, the sealing process, and the use of many facilities for the PCB-chips. The larger the numbers of integrated sensors and actuators in the PCB-chip, the more complex the fabrication. In addition, the flow driving-integrated devices increase that difficulty. Moreover, the biological applications are demanding. They require transparency, biocompatibility, and specific ambient conditions. All the problems have to be solved when trying to reach repetitiveness and reliability, for both the fabrication process and the working of the lab-on-PCB, including the flow driving system.

show abstract

“…To construct the proposed micropump, we used Ostemer 322 (Mercene Labs, Sweden) as the main material to overcome the limitation of the material properties of PDMS. Ostemer 322 has several advantages, such as ability to fabricate stiff device by soft lithography (high Young's modulus of 1 GPa), two-step curing process for easy shaping, low absorbance of solution, solvent resistance and high transparency, and its biocompatibility has been also evaluated in Ostemer-based microfluidic device for organ-on-a-chip applications by Sticker et al [19][20][21][22]. Figure 2 I shows the major fabrication process of the proposed micropump, including the PDMS master mold fabrication, the main body casting, and the total assembly.…”

Section: Fabrication Process For Micropump Embedded In Contact Lensmentioning

confidence: 99%

Magnetic micropump embedded in contact lens for on-demand drug delivery

Wang

Park

2020

Micro and Nano Syst Lett

View full text Add to dashboard Cite

In this paper, we report a thin magnetic micropump embedded in contact lens, which is capable of on-demand one-directional drug delivery. The proposed micropump can be actuated by the external magnetic field whenever needed without the need of battery. A micro check valve was integrated with the micropump for one-directional drug delivery from the micropump to the post-lens tear film. With actuation of the external magnetic field, the micro check valve is opened, and on-demand drug release can be realized. On the contrary, without an external magnetic field, the micro check valve is closed, and the undesired drug diffusion can be prevented. Through the control of the strength and the frequency of the magnetic field pulse, on-demand drug release and controlled dose can be realized. Publisher's NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

show abstract

OSTEMER polymer as a rapid packaging of electronics and microfluidic system on PCB

Cited by 10 publications

References 26 publications

Device Processing Challenges for Miniaturized Sensing Systems Targeting Biological Fluids

Device Processing Challenges for Miniaturized Sensing Systems Targeting Biological Fluids

Lab-on-PCB and Flow Driving: A Critical Review

Magnetic micropump embedded in contact lens for on-demand drug delivery

Contact Info

Product

Resources

About