Osteoclast resorption of thermal spray hydoxyapatite coatings is influenced by surface topography

Gross, Kārlis Agris; Müller, D.M.; Lucas, Helen; Haynes, David R.

doi:10.1016/j.actbio.2012.01.023

Cited by 28 publications

(25 citation statements)

References 40 publications

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“…Gross et al . () found that the resorption of human‐derived osteoclasts revealed a 10‐fold greater number of resorption pits on dentine and on thermally sprayed coatings compared to polished coatings. These authors hypothesized that HA coatings with rougher topography undergo active remodelling, like dentine.…”

Section: Different Materials Parameters Influencing Osteoclastogenesismentioning

confidence: 99%

The role of osteoclasts in bone tissue engineering

Detsch

Boccaccını

2014

J Tissue Eng Regen Med

127

108

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The success of scaffold-based bone regeneration approaches strongly depends on the performance of the biomaterial utilized. Within the efforts of regenerative medicine towards a restitutio ad integrum (i.e. complete reconstruction of a diseased tissue), scaffolds should be completely degraded within an adequate period of time. The degradation of synthetic bone substitute materials involves both chemical dissolution (physicochemical degradation) and resorption (cellular degradation by osteoclasts). Responsible for bone resorption are osteoclasts, cells of haematopoietic origin. Osteoclasts play also a crucial role in bone remodelling, which is essential for the regeneration of bone defects. There is, however, surprisingly limited knowledge about the detailed effects of osteoclasts on biomaterials degradation behaviour. This review covers the relevant fundamental knowledge and progress made in the field of osteoclast activity related to biomaterials used for bone regeneration. In vitro studies with osteoclastic precursor cells on synthetic bone substitute materials show that there are specific parameters that inhibit or enhance resorption. Moreover, analyses of the bone-material interface reveal that biomaterials composition has a significant influence on their degradation in contact with osteoclasts. Crystallinity, grain size, surface bioactivity and density of the surface seem to have a less significant effect on osteoclastic activity. In addition, the topography of the scaffold surface can be tailored to affect the development and spreading of osteoclast cells. The present review also highlights possible areas on which future research is needed and which are relevant to enhance our understanding of the complex role of osteoclasts in bone tissue engineering.

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Section: Different Materials Parameters Influencing Osteoclastogenesismentioning

confidence: 99%

The role of osteoclasts in bone tissue engineering

Detsch

Boccaccını

2014

J Tissue Eng Regen Med

127

108

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“…The interactions of CaPO 4 deposits with either cells in vitro or surrounding tissues in vivo have been studied a lot [36,120,130,236,244,269,314,316,317,391,478,559,566,574,[824][825][826][827][828][829][830][831][832][833][834][835][836][837][838][839][840][841][842]. Similar to the aforementioned, until the CaPO 4 deposits become so thin that cells and tissues will get the direct access to the surface of the substrates, their interactions with cells appear to be similar to that of CaPO 4 bulk bioceramics having the same structure, composition and properties.…”

Section: Interaction With Cells and Tissue Responsesmentioning

confidence: 99%

Calcium orthophosphate deposits: Preparation, properties and biomedical applications

Dorozhkin¹

2015

Materials Science and Engineering: C

262

140

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“…Murine RAW.246.7 or mouse marrow-derived cells are largely employed in studies of osteoclasts on ceramics [5][6][7], with only a few publications addressing osteoclast differentiation of human monocytes on ceramic substitutes [8,9]. These studies have shown that osteoclasts are sensitive to different material properties, such as chemical composition and topography.…”

Section: Introductionmentioning

confidence: 99%