Osteoclastogenesis from bone marrow cells during estrogen-induced medullary bone formation in Japanese quails

Hiyama, Shinji; Yokoi, Miyuki; Akagi, Yoshio; Kadoyama, Yumiko; Nakamori, Kiichi; Tsuga, Kazuhiro; Uchida, Takashi; Terayama, Ryuji

doi:10.1007/s10735-019-09835-x

Cited by 8 publications

(5 citation statements)

References 44 publications

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“…Its matrix is different from that of cortical bone [90,91]. On the other hand, osteoclasts from medullary bone accelerate the supply of calcium during the egg-laying cycle and for this reason, it is during this period that the most rapid bone turnover is observed [90,92]. Analysis of other bone parameters proved intensive bone turnover and effective anti-osteoporotic action of AKG in the medullary bone of the laying hens.…”

Section: Discussionmentioning

confidence: 99%

Alpha-Ketoglutarate: An Effective Feed Supplement in Improving Bone Metabolism and Muscle Quality of Laying Hens: A Preliminary Study

Tomaszewska

Świątkiewicz

Arczewska-Włosek

et al. 2020

Animals

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The aim of the experiment was to assess the effect of dietary alpha-ketoglutarate (AKG) supplementation on performance, serum hormonal indices, duodenum and jejunum histomorphometry, meat quality characteristics, bone quality traits and cartilage degradation in laying hens with a mature skeletal system. Forty-eight 30 week-old Bovans Brown laying hens were randomly assigned to a control group or the group fed the basal diet plus 1.0% AKG. The experimental trial lasted 30 weeks. The supplementation of AKG increases blood serum content of leptin, ghrelin, bone alkaline phosphatate and receptor activator of nuclear factor kappa-Β ligand, while osteoprotegerin and osteocalcin decrease. While dietary AKG was given to laying hens negatively influenced villus length, crypt depth, villus/crypt ratio and absorptive surface area in duodenum and jejunum, these changes have no effect on feed intake, weight gain, nor laying performance. In breast muscles, no significant changes in skeletal muscle fatty acid composition were observed, however, a higher shear force and decreased cholesterol content following AKG supplementation were noted, showing the improvement of muscle quality. While dietary AKG supplementation did not affect the general geometric and mechanical properties of the tibia, it increased collagen synthesis and enhanced immature collagen content. In medullary bone, an increase of bone volume fraction, trabecular thickness, fractal dimension and decrease of trabecular space were observed in AKG supplemented group. The trabeculae in bone metaphysis were also significantly thicker after AKG supplementation. AKG promoted fibrillogenesis in articular cartilage, as indicated by increased cartilage oligomeric matrix protein immunoexpression. By improving the structure and maintaining the proper bone turnover rate of highly reactive and metabolically active medullar and trabecular bones AKG showed its anti-osteoporotic action in laying hens.

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Section: Discussionmentioning

confidence: 99%

Alpha-Ketoglutarate: An Effective Feed Supplement in Improving Bone Metabolism and Muscle Quality of Laying Hens: A Preliminary Study

Tomaszewska

Świątkiewicz

Arczewska-Włosek

et al. 2020

Animals

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“…Interestingly, the thickest growth plate cartilage was observed in tibiae of bee pollen supplemented females from meat-PLOS ONE type line, which were characterized by the one of the lowest mechanical strength and mineralization. The deceleration of bone maturation can be associated with the activity of growth factors involved in bone growth such as osteocalcin, insulin-like growth factor I (IGF-I) and steroid hormones [16,21,[47][48][49]. There is a study suggesting that bee pollen can act on bone maturation through modulation of the activity of bone growth factors, as Kolesárová et al [50] report increase in progesterone and estradiol production and decrease in the secretion of IGF-I in female rats after bee pollen supplementation at the dose of 0.5% of feed for 90 days.…”

Section: Plos Onementioning

confidence: 99%

“…As an animal avian model, Japanese quail is often used in studies of the toxicology of chemical compounds and the effects of environmental endocrine disruptors or in examining the physiological processes in birds [11][12][13]. Quails are also used as an animal model for studying bone formation and development, both in pre-hatch and post-hatch studies [14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

The effect of bee pollen on bone biomechanical strength and trabecular bone histomorphometry in tibia of young Japanese quail (Coturnix japonica)

et al. 2020

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It has been demonstrated in numerous studies that bee pollen supplementation shows numerous positive effects on health. However, its impact on bones is largely unknown. The purpose of this study was to investigate the effect of bee pollen supplementation on the tibia biomechanical properties and bone morphometric measures using Japanese quail as an animal model. The experiment was arranged in a 2x2x2 factorial design, with sex, quail line (meat-type or egg-lying type), and bee pollen inclusion (0 or 10 g/kg of feed) as factors. The quails were one-day-old at the beginning of the experiment, they were euthanized after 42 days. Our study showed for the first time unfavorable effects of bee pollen on bones properties. Bee pollen supplementation negatively affected bone structure, irrespective of quails' sex or line type. Bone length (P < 0.001), weight (P < 0.01), and mean relative wall thickness (P < 0.01) and mineralization (P < 0.05) were reduced by bee pollen treatment. For female quails, irrespective of line type, the decrease of yield load (P < 0.001), ultimate load (P < 0.01), yield stress (P < 0.001) and ultimate stress (P < 0.05) was noted. Analysis of growth plate in bone metaphysis showed that bee pollen supplementation slowed the process of bone maturation irrespective of sex (P < 0.05). On contrary, dietary bee pollen positively affected bone homeostasis of trabecular bone in bone metaphysis as bone mineral density increased in experimental groups (P < 0.05). In males, this was the result of the increase of trabecular thickness (P < 0.01), in females due to the reduction of trabecular space (P < 0.001). In conclusion, our results demonstrate that bee pollen (1.0%, 10 g/kg of feed) supplementation caused significant negative effects on the mechanical endurance of the tibia of quails, while showed beneficial effects on trabecular bone histomorphometry.

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“…Bone marrow-derived macrophages ( BMMs ), as osteoclast precursors, can regulate RANK (receptor activator of nuclear factor κ B) expression via modulation of the cell adhesion signaling ( Mochizuki et al, 2012 ). According to a reported study on Japanese quails, E2-induced osteoclastogenesis can be regulated in the bone marrow cells via the RANK/RANKL/OPG (RANK/RANK Ligand/Osteoprotegerin) system during medullary bone formation ( Hiyama et al, 2019 ). Moreover, in prepubertal ovariectomy mice, E2 deficiency can promote both maxilla and mandible growth, accompanied by an increase in RANKL/OPG ratio ( Omori et al, 2020 ; Küchler et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic analysis reveals the molecular mechanisms underlying osteoclast differentiation in the estrogen-deficient pullets

Yue¹,

Huang²,

Song³

et al. 2023

Poultry Science

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Osteoclastogenesis from bone marrow cells during estrogen-induced medullary bone formation in Japanese quails

Cited by 8 publications

References 44 publications

Alpha-Ketoglutarate: An Effective Feed Supplement in Improving Bone Metabolism and Muscle Quality of Laying Hens: A Preliminary Study

Alpha-Ketoglutarate: An Effective Feed Supplement in Improving Bone Metabolism and Muscle Quality of Laying Hens: A Preliminary Study

The effect of bee pollen on bone biomechanical strength and trabecular bone histomorphometry in tibia of young Japanese quail (Coturnix japonica)

Transcriptomic analysis reveals the molecular mechanisms underlying osteoclast differentiation in the estrogen-deficient pullets

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