Osteogenic differentiation of MC3T3-E1 cells on poly(l-lactide)/Fe3O4 nanofibers with static magnetic field exposure

Cai, Qing; Shi, Yuzhou; Shan, Dingying; Jia, Wenkai; Duan, Shun; Deng, Xuliang; Yang, Xiaoping

doi:10.1016/j.msec.2015.05.002

Cited by 55 publications

(37 citation statements)

References 27 publications

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“…Many materials have been fabricated by electrospinning, including poly (L-lactic acid) (PLLA), polyglycolic acid (PGA) and silk fibroin (SF) (Sekiya et al 2013;Jeong et al 2014;Cai et al 2015;Zhao et al 2015). Among these materials, SF has attracted increasing research interest because of its benign biocompatibility and excellent mechanical properties (Shao and Vollrath 2002).…”

Section: Introductionmentioning

confidence: 99%

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

Zhi

Zhang

et al. 2016

Biotechnol Lett

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Section: Introductionmentioning

confidence: 99%

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

Zhi

Zhang

et al. 2016

Biotechnol Lett

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“…[15,16] Particularly, NP-loaded systems enhance cellular processes in vitro. For example, PLLA/iron oxide nanocomposites have shown neurite extension in electrospun microfibers, Cai et al showed that PLLA/Fe 3 O 4 composites enhanced osteogenic differentiation [17] and in a similar way Dong et al showed enhanced osteogenic differentiation with PLLA/dicalcium silicate fibres. [18] In this context, ZnO NPs have attracted attention as antimicrobials [19,20] and UV blockers, [21] among others.…”

Section: Introductionmentioning

confidence: 97%

PLLA/ZnO nanocomposites: Dynamic surfaces to harness cell differentiation

Trujillo

Lizundia

Vilas

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Graphical abstract2 Highlights  Biodegradable poly(L-lactide) matrix loaded with ZnO nanorods. Dynamic presentation of nanorods triggered by PLLA degradation. Changes in surface properties as a function of time control cell behaviour. Nanorods exposure promotes cell differentiation.3 Keywords: PLLA, ZnO nanoparticle, C2C12 myoblast, nanocomposite, cell differentiation AbstractThis work investigates the effect of the sequential availability of ZnO nanoparticles, (nanorods of ~ 20 nm) loaded within a degradable poly(lactic acid) (PLLA) matrix, in cell differentiation. The system constitutes a dynamic surface, in which nanoparticles are exposed as the polymer matrix degrades. ZnO nanoparticles were loaded into PLLA and the system was measured at different time points to characterise the time evolution of the physicochemical properties, including wettability and thermal properties. The micro and nanostructure were also investigated using AFM, SEM and TEM images. Cellular experiments with C2C12 myoblasts show that cell differentiation was significantly enhanced on ZnO nanoparticles -loaded PLLA, as the polymer degrades and the availability of nanoparticles become more apparent, whereas the release of zinc within the culture medium was negligible. Our results suggest PLLA/ZnO nanocomposites can be used as a dynamic system where nanoparticles are exposed during degradation, activating the material surface and driving cell differentiation.4

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“…(26) It can thus be beneficial to modulate growth factor release post-implantation using external stimuli. The usage of external physical stimuli to modulate behavior of tissue engineering scaffolds has gained popularity in recent years,(44–46) though few approaches have applied this methodology so far to 3DP scaffolds. One very interesting approach by Gupta et al utilized 3D-printed PLGA shells doped with plasmonic gold nanorods (AuNRs) to achieve photothermally mediated rupture of the shells and subsequent release of a payload from the aqueous core (Figure 1).…”

Section: Fabricating Spatiotemporal Growth Factor Patternsmentioning

confidence: 99%

Spatiotemporal control of growth factors in three-dimensional printed scaffolds

Bittner

Guo

2018

Bioprinting

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Three-dimensional printing (3DP) has enabled the fabrication of tissue engineering scaffolds that recapitulate the physical, architectural, and biochemical cues of native tissue matrix more effectively than ever before. One key component of biomimetic scaffold fabrication is the patterning of growth factors, whose spatial distribution and temporal release profile should ideally match that seen in native tissue development. Tissue engineers have made significant progress in improving the degree of spatiotemporal control over which growth factors are presented within 3DP scaffolds. However, significant limitations remain in terms in pattern resolution, the fabrication of true gradients, temporal control of growth factor release, the maintenance of growth factor distributions against diffusion, and more. This review summarizes several key areas for advancement of the field in terms of improving spatiotemporal control over growth factor presentation, and additionally highlights several major tissues of interest that have been targeted by 3DP growth factor patterning strategies.

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Osteogenic differentiation of MC3T3-E1 cells on poly(l-lactide)/Fe3O4 nanofibers with static magnetic field exposure

Cited by 55 publications

References 27 publications

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

PLLA/ZnO nanocomposites: Dynamic surfaces to harness cell differentiation

Spatiotemporal control of growth factors in three-dimensional printed scaffolds

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