Osteoinductive potential and antibacterial characteristics of collagen coated iron oxide nanosphere containing strontium and hydroxyapatite in long term bone fractures

Wei, Xianhui; Zhang, Xiakun; Zhan, Yang; Li, Liang; Sui, Haitao

doi:10.1016/j.arabjc.2020.102984

Cited by 14 publications

(10 citation statements)

References 68 publications

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“…Attempts to modify biomaterials with strontium ions are still valid. Recent papers report the use of materials such as iron oxide nanospheres-hydroxyapatite-strontium@collagen (IONSs-HA-SR@C) [ 94 ] or macroporous iron foams coated with strontium [ 95 ]. Such materials appear to be particularly useful in the osteoporotic fracture defect healing, as research shows significantly increased bone formation at the implant interface with increased osteoblast and decreased osteoclast activity.…”

Section: Strontium In the Treatment Of Osteoporosismentioning

confidence: 99%

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

Kołodziejska

Stępień

Kolmas

2021

IJMS

164

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Osteoporosis is a chronic disease characterized by low bone mass caused by increased bone turnover and impaired bone microarchitecture. In treatment, we use antiresorptive or anabolic drugs, which usually have a unidirectional effect, i.e., they inhibit the activity of osteoclasts or stimulate the effect of osteoblasts. Strontium ranelate is an anti-osteoporosis drug with a unique mechanism of action (used primarily in postmenopausal women). Unlike other medicines, it has a multidirectional effect on bone tissue, intensifying osteoblastogenesis while inhibiting osteoclastogenesis. It turns out that this effect is demonstrated by strontium ions, an element showing physical and chemical similarity to calcium, the basic element that builds the mineral fraction of bone. As a result, strontium acts through the calcium-sensing receptor (CaSR) receptor in bone tissue cells. In recent years, there has been a significant increase in interest in the introduction of strontium ions in place of calcium ions in ceramics used as bone replacement materials for the treatment of bone fractures and defects caused by osteoporosis. The aim of this study was to summarize current knowledge about the role of strontium in the treatment of osteoporosis, its effects (in various forms), and the ways in which it is administered.

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Section: Strontium In the Treatment Of Osteoporosismentioning

confidence: 99%

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

Kołodziejska

Stępień

Kolmas

2021

IJMS

164

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“…The HA/Col composites had been prepared through different fabricated techniques and were used in many bone defects as biomaterials for bone tissue engineering. The composite have been incorporated by different sizes (Nano-size and micro-size) with many other materials such as calcium phosphate (CaP) [20], poly(L-lactide) (PLLA) [21], Poly(vinyl alcohol) (PVA) [22], chitosan [23], and metals such as iron (Fe) [24], to develop the properties of the composites, which will possess high compatibility and bio-degradable properties for bone repair.…”

Section: Preparation Methods Of Ha/col Compositesmentioning

confidence: 99%

The Natural and Commercial Sources of Hydroxyapatite/Collagen Composites for Biomedical Applications: A Review Study

et al. 2022

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Bone is considered the core unit that forms the human body’s skeleton, consisting primarily of hydroxyapatite (HA) and collagen (Col). The composites of hydroxyapatite/collagen had been prepared through different fabricated techniques and were used in many bone defects as biomaterials for bone tissue engineering. The incorporation of HA and collagen is possible due to the biocompatibility of collagen and the high mechanical properties of the HA. HA/Col composites have been used in many medical and biological fields. Current study have been discussed the synthesis and characterization techniques of HA/Col composites; the study have been included to study the cytotoxicity and cell attachment of the composites, along with their applications, as well as barriers that still remain to their successful development for clinical application.

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“…Although good efficacy levels, the lack of an adequate level of osteoinductivity and/or osteoconductivity led to the addition of other components such as metals, in particular iron, manganese (Yu et al, 2020), and strontium (Montalbano et al, 2020;Wei et al, 2021), or cytokines belonging to β-TGF superfamily, namely, bone morphogenetic proteins (BMPs) (Dawson et al, 2009;Lu et al, 2012;Oryan et al, 2014). Among metals, Fe/Mn-enriched collagen-hydroxyapatite scaffolds manifested enhanced adhesion and proliferation of osteoblasts, promoted bone sialoprotein, dentin matrix acidic phosphoprotein 1 expressions, alkaline phosphatase activity, and increased osteogenic-specific gene expression in in vitro osteogenic culture and much better in vivo bone-regenerating capability compared to scaffolds without Fe/Mn or Healos, a commercial collagen-hydroxyapatite-based scaffold (Yu et al, 2020).…”

Section: Bonementioning

confidence: 99%

Mimicking the Hierarchical Organization of Natural Collagen: Toward the Development of Ideal Scaffolding Material for Tissue Regeneration

Salvatore

Gallo

Natali

et al. 2021

Front. Bioeng. Biotechnol.

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Biological materials found in living organisms, many of which are proteins, feature a complex hierarchical organization. Type I collagen, a fibrous structural protein ubiquitous in the mammalian body, provides a striking example of such a hierarchical material, with peculiar architectural features ranging from the amino acid sequence at the nanoscale (primary structure) up to the assembly of fibrils (quaternary structure) and fibers, with lengths of the order of microns. Collagen plays a dominant role in maintaining the biological and structural integrity of various tissues and organs, such as bone, skin, tendons, blood vessels, and cartilage. Thus, “artificial” collagen-based fibrous assemblies, endowed with appropriate structural properties, represent ideal substrates for the development of devices for tissue engineering applications. In recent years, with the ultimate goal of developing three-dimensional scaffolds with optimal bioactivity able to promote both regeneration and functional recovery of a damaged tissue, numerous studies focused on the capability to finely modulate the scaffold architecture at the microscale and the nanoscale in order to closely mimic the hierarchical features of the extracellular matrix and, in particular, the natural patterning of collagen. All of these studies clearly show that the accurate characterization of the collagen structure at the submolecular and supramolecular levels is pivotal to the understanding of the relationships between the nanostructural/microstructural properties of the fabricated scaffold and its macroscopic performance. Several studies also demonstrate that the selected processing, including any crosslinking and/or sterilization treatments, can strongly affect the architecture of collagen at various length scales. The aim of this review is to highlight the most recent findings on the development of collagen-based scaffolds with optimized properties for tissue engineering. The optimization of the scaffolds is particularly related to the modulation of the collagen architecture, which, in turn, impacts on the achieved bioactivity.

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Osteoinductive potential and antibacterial characteristics of collagen coated iron oxide nanosphere containing strontium and hydroxyapatite in long term bone fractures

Cited by 14 publications

References 68 publications

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

The Natural and Commercial Sources of Hydroxyapatite/Collagen Composites for Biomedical Applications: A Review Study

Mimicking the Hierarchical Organization of Natural Collagen: Toward the Development of Ideal Scaffolding Material for Tissue Regeneration

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