2016
DOI: 10.3233/cbm-160617
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Osteopontin as a discriminating marker for pancreatic cancer and chronic pancreatitis

Abstract: Our pilot study demonstrates the usefulness of estimating OPN levels to differentiate between pancreatic cancer and chronic pancreatitis. Higher OPN levels over 102 ng/ml could be a potential diagnostic biomarker for pancreatic cancer.

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Cited by 27 publications
(21 citation statements)
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“…In an autoimmune pancreatitis (AIP) model of WBN/Kob rats, the expression of OPN in centroacinar cells in CP with calcification and in AIP is considerably greater than that in normal pancreas [ 120 ]. OPN is also used as a discriminating marker for pancreatic cancer (PC) and CP [ 121 ]. OPN influences the invasiveness of PC cells and increases in neoplastic and inflammatory conditions [ 122 ].…”
Section: The Association Of Opn With Apoptosis In Inflammatory Gi mentioning
confidence: 99%
“…In an autoimmune pancreatitis (AIP) model of WBN/Kob rats, the expression of OPN in centroacinar cells in CP with calcification and in AIP is considerably greater than that in normal pancreas [ 120 ]. OPN is also used as a discriminating marker for pancreatic cancer (PC) and CP [ 121 ]. OPN influences the invasiveness of PC cells and increases in neoplastic and inflammatory conditions [ 122 ].…”
Section: The Association Of Opn With Apoptosis In Inflammatory Gi mentioning
confidence: 99%
“…OPN is a major mediator of inflammation-a key factor in carcinogenesis with multi-functional activities [117,118]. The up-regulation of OPN expression has been identified in a variety of human cancers, including but not limited to breast [119], ovarian [120], prostate [121], and oral cavity cancers [122], lung [123], liver [124], gastric [125], pancreatic [126], and colorectal cancers [127], glioma [128], thyroid carcinoma [129], and melanoma cancer [130]. The WHO technical report identifies breast cancer as the most common cancer among women, with the highest incidence in 2018 (11.6% of all cancers) [1].…”
Section: Osteopontinmentioning
confidence: 99%
“…A meta-analysis published in 2014 demonstrated that the serum OPN levels in patients with PC was significantly greater compared to controls[ 60 ]. More recently, a pilot study published in 2016 identified that levels of OPN were higher in patients with PC compared to those with CP and control subjects, further affirming its potential role as a diagnostic biomarker in PC[ 61 ].…”
Section: Serological Biomarkers Of Pcmentioning
confidence: 99%