Osteoprotegerin and bone mineral density in hemodialysis patients

Nakashima, Ayumu; Yorioka, Noriaki; Doi, Shigehiro; Takasugi, Norihisa; Shigemoto, Kazuhiro; Kohno, Nobuoki

doi:10.1007/s00198-005-0047-0

Cited by 23 publications

(16 citation statements)

References 23 publications

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“…There was also no significant change in the control group. We previously found that the serum OPG level showed a negative correlation with bone metabolism markers in hemodialysis patients [23]. Though we could not detect any strong effect of vitamin K 2 on serum OPG levels in this study, the decrease of OPG might have been involved in the changes of bone metabolism markers in the vitamin K 2 group.…”

Section: Discussioncontrasting

confidence: 51%

Vitamin K<sub>2</sub> Alters Bone Metabolism Markers in Hemodialysis Patients with a Low Serum Parathyroid Hormone Level

Ochiai

Nakashima²,

Takasugi³

et al. 2010

Nephron Clin Pract

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Background: A low level of intact parathyroid hormone (PTH) is an indicator of adynamic bone disease in hemodialysis patients, and is associated with a significant increase of all-cause mortality. Thus, effective treatment for adynamic bone disease is required. We previously investigated the effect of vitamin K₂ on adynamic bone disease. In this study, we assessed the efficacy of oral vitamin K₂ in a controlled trial. Methods: Forty hemodialysis patients with low intact PTH levels (<100 pg/ml) were randomly divided into two groups, which were a vitamin K₂ group receiving oral menatetrenone (45 mg/day) for 1 year and a control group without vitamin K₂. Venous blood samples were collected at baseline and during the study for measurement of bone metabolism parameters. Results: Thirty-three patients completed follow-up. There was a significant increase of the serum intact osteocalcin level after 1 month of vitamin K₂ administration. Serum levels of intact PTH, bone alkaline phosphatase, and cross-linked N-terminal telopeptide of type I collagen increased significantly after 12 months in the vitamin K₂ group. The serum osteoprotegerin level was decreased after 12 months in the vitamin K₂ group, but the change was not significant. Conclusion: Vitamin K₂ therapy improves bone remodeling in hemodialysis patients with a low intact PTH level.

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Section: Discussioncontrasting

confidence: 51%

Vitamin K<sub>2</sub> Alters Bone Metabolism Markers in Hemodialysis Patients with a Low Serum Parathyroid Hormone Level

Ochiai

Nakashima²,

Takasugi³

et al. 2010

Nephron Clin Pract

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“…Parathyroid hormone has been regarded as one of the biomarkers to evaluate bone turnover in CKD patients. However, its impact on BMD in CKD patients was controversial . Our cross‐sectional study failed to demonstrate a significant relationship between iPTH levels and BMD.…”

Section: Discussionmentioning

confidence: 61%

Triceps Skinfold Thickness Is Associated With Lumbar Bone Mineral Density in Peritoneal Dialysis Patients

et al. 2016

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Anthropometric measurements, including body mass index (BMI), body weight and total fat mass are associated with the bone mineral density (BMD) in the general population. Compared to that in the general population, BMD was lower in dialysis patients. However, the association between anthropometric measurements and BMD is not well-established among peritoneal dialysis (PD) patients. To study this, we conducted a cross-sectional study in 48 chronic PD patients. Anthropometric parameters, biochemical data, and BMD measured by dual energy X-ray absorptiometry in lumbar vertebrae (L2-L4) were collected. Among these PD patients, eight patients (16.7%) had osteoporosis and 22 patients (45.8%) osteopenia, while 18 patients were normal. Older age, decreased height, lower body weight, BMI, triceps skinfold thickness (TSF), mid-arm fat area (MAFA), and higher adiponectin levels were observed in our patients with lower lumbar T-scores. Height, body weight, waist circumference, BMI, body fat mass, TSF, mid-arm circumference, MAFA, and serum phosphorus levels were positively, while age, adiponectin levels were negatively correlated with lumbar BMD levels. According to our multivariate forward stepwise linear regression analysis, TSF (R change = 0.080, P = 0.017) and body weight (R change = 0.333, P = 0.002) were both correlated with low lumbar BMD. In conclusion, either TSF or body weight in our chronic PD patients was proved to be an independent predictor for osteolytic bone lesions.

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“…OPG concentrations are reported to be higher in HD patients [35][36][37][38][39], whereas RANKL level can be higher [39,40], lower [36] or within normal range [41] compared to healthy individuals. Kazama showed that serum OPG levels in uremic patients were elevated and independent of their serum PTH levels, what suggested the circulating OPG to be an independent factor affecting bone metabolism in uremic patients [42].…”

Section: Opg/rank/rankl System In Esrdmentioning

confidence: 99%

OPG/RANK/RANKL signaling system and its significance in nephrology.

Klejna

Naumnik²,

Gasowska³

et al. 2009

Folia Histochem Cytobiol.

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Osteoprotegerin and bone mineral density in hemodialysis patients

Abstract: These correlations of osteoprotegerin are opposite to those found in healthy persons. However, osteoprotegerin might act to prevent bone loss even in hemodialysis patients.

Cited by 23 publications

References 23 publications

Vitamin K<sub>2</sub> Alters Bone Metabolism Markers in Hemodialysis Patients with a Low Serum Parathyroid Hormone Level

Vitamin K<sub>2</sub> Alters Bone Metabolism Markers in Hemodialysis Patients with a Low Serum Parathyroid Hormone Level

Triceps Skinfold Thickness Is Associated With Lumbar Bone Mineral Density in Peritoneal Dialysis Patients

OPG/RANK/RANKL signaling system and its significance in nephrology.

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