Osteosarcoma of the Uterus. Report of a Case

Gilmore, George H.; Hepler, Thomas K.; Herbut, Peter A.; Levinson, John M.; Scheffey, Lewis C.

doi:10.1097/00006254-195708000-00047

Cited by 5 publications

(5 citation statements)

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“…The clinicopathological features of the 14 reported cases and our present case of uterine osteosarcoma are summarized in Table 1 10–23 . The mean age of patients was 62 years (range 41–82 years), and the mean survival time was 8.5 months (range 3 days−52 months in 11 cases that died).…”

Section: Discussionmentioning

confidence: 91%

“…Mechanical injury and radiation are considered to be pathogenic factors for osteosarcoma of soft tissue 1 . Although one reported case had received radiation therapy for a uterine myoma 34 years prior to the onset of the osteosarcoma, 12 it is not yet clear whether radiation could induce this tumor or not. The pathogenesis of this tumor is unknown to date.…”

Section: Discussionmentioning

confidence: 99%

“…While most extraskeletal osteosarcomas originate from soft tissue, 3–5 primary osteosarcomas from the breast, urinary bladder, heart, lung and uterus have also been reported 6–10 . Since a case of osteosarcoma of the uterus was reported by Stier and Lyman in 1936, 10 only 14 cases of uterine osteosarcoma have been reported to date 10–23 . We report here a case of osteosarcoma, apparently originating from the uterine corpus, that showed an extremely aggressive nature.…”

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confidence: 81%

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Primary osteosarcoma of the uterine corpus: Case report and review of the literature

Tokairin

Nishikawa

et al. 2002

Pathology International

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A rare case of rapidly growing osteosarcoma that developed in the uterine corpus of a 62-year-old woman is presented. The tumor occupied almost the entire pelvic cavity and extended into the abdominal cavity, with marked involvement of the intestines. Histopathologically, the tumor was composed of an osteoblastic component, accompanied by conspicuous bone formation, and a fibroblastic component. The tumor cells were positive for vimentin and osteocalcin, as well as desmin, alpha-smooth muscle actin and muscle-specific actin, but negative for h-caldesmon. The results indicated myofibroblastic differentiation in a part of the tumor. A review of 14 reported cases and our case of uterine osteosarcoma revealed that this tumor has a biologically aggressive nature, although its histopathological and immunohistochemical features are similar to those of osteosarcomas in soft tissue and bone. As the prognosis of patients with this tumor is poor, it is of importance to differentiate this tumor from other types of tumors arising from the uterine corpus.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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confidence: 81%

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Primary osteosarcoma of the uterine corpus: Case report and review of the literature

Tokairin

Nishikawa

et al. 2002

Pathology International

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“…It is theoretically possible for a liposarcoma to arise in a preexisting leiomyoma by metaplasia and malignant transformation. In support of such a possibility are the reports of Scheffey et al (11) and Stier and Lyman (12), which describe cases of primary osteosarcoma of the uterus origi-nating in a preexisting leiomyoma. These observations, together with the well-circumscribed configuration of the cervical tumor and the associated uterine leiomyoma in our case, suggest that the liposarcoma originates in a preexisting cervical leiomyoma.…”

Section: Discussionmentioning

confidence: 96%

Primary Liposarcoma of the Cervix: A Case Report

Veliath

Hannah

Ratnakar

et al. 1978

International Journal of Gynecology & Obstetrics

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“…169 OSTEOSARCOMA Uterine neoplasms displaying osseous differentiation are most commonly malignant mixed Mu¨llerian tumors. However, 19 osteosarcomas without a clearly demonstrable epithelial component have been reported, [170][171][172][173][174][175][176][177][178][179][180][181][182][183][184][185][186][187][188] in women ranging in age from 41 to 82 years (median 62 y; Table 6). Osteosarcomas of the uterus are highly aggressive neoplasms, and the calculated median survival for these 123 50…”

Section: Dod 19 Momentioning

confidence: 99%

Heterologous and Rare Homologous Sarcomas of the Uterine Corpus

Fadare¹

2011

Advances in Anatomic Pathology

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Pure sarcomas of the uterine corpus are uncommon, constituting less than 3% of all malignancies at this site, and most of them are leiomyosarcomas and endometrial stromal sarcomas. Rare histotypes of homologous sarcomas and heterologous sarcomas are occasionally encountered, and the absence of significant accumulated experience with these histotypes at this location may potentially raise diagnostic and patient management difficulties. In this article, the clinicopathologic attributes of all earlier reported sarcomas of the uterine corpus other than leiomyosarcomas and endometrial stromal sarcomas are summarized. Included are embryonal rhabdomyosarcoma, pleomorphic rhabdomyosarcoma, angiosarcoma, alveolar soft part sarcoma, malignant perivascular epithelioid cell tumors (PEComas), osteosarcoma, chondrosarcoma, liposarcomatous tumors, malignant extrarenal rhabdoid tumors, Ewing sarcoma/primitive neuroectodermal tumor, and other rare histotypes. Embryonal rhabdomyosarcoma (20%), Ewing sarcoma/primitive neuroectodermal tumor (17%), angiosarcoma (14%), and pleomorphic rhabdomyosarcoma (13%) appeared to be more common than the others, although there was no single overwhelmingly prevalent histotype in the group. A subset, including embryonal rhabdomyosarcoma, alveolar soft part sarcoma, and PEComas, peak in the premenopausal years, but most of the others were observed in postmenopausal women. Favorable outcomes have been reported for the patients diagnosed with alveolar soft part sarcoma, and the prognosis for their counterparts with PEComa remains a matter of debate. Multimodal therapeutic approaches to contemporary patients with embryonal rhabdomyosarcomas have resulted in significantly improved outcomes. Unfortunately, most of the other sarcomas have been associated with rapid tumor progression and unfavorable patient outcomes. The differential diagnosis for these sarcomas is often extensive and varies by histotype, but their accurate diagnosis fundamentally requires the careful exclusion of biphasic malignancies.

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Osteosarcoma of the Uterus. Report of a Case

Cited by 5 publications

References 0 publications

Primary osteosarcoma of the uterine corpus: Case report and review of the literature

Primary osteosarcoma of the uterine corpus: Case report and review of the literature

Primary Liposarcoma of the Cervix: A Case Report

Heterologous and Rare Homologous Sarcomas of the Uterine Corpus

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