Outcome by treatment modality in sinonasal undifferentiated carcinoma (SNUC): A case-series, systematic review and meta-analysis

Abstract

Double and triple modality treatment are associated with improved survival over single modality but there is no evidence that triple modality is superior to double modality treatment.

Incidence and survival in sinonasal carcinoma: a Danish population-based, nationwide study from 1980 to 2014

“…This was only significantly higher than the survival in the UC, which had a five year survival of 29% (95% CI 20;40) ( Table 1 and Figure 2(A)). The latter containing the sinonasal undifferentiated carcinoma, which is known to carry a poor prognosis [22].…”

Treatment of Sinonasal Undifferentiated Carcinoma with TPF and Concurrent Chemo-Radiation: Case Report and Literature Review

“…Based off of literature review and prior case series, the multiple modality approach should result in the best possible outcome for this rare and aggressive disease [4, 5, 9]. In this specific case of a young Hispanic male with Stage IVB SNUC, we proceeded with Neoadjuvant TPF with effective results, followed by Cisplatin and concurrent radiation once the patient had interval progression, and was deemed unresectable.…”

“…It is immunohistochemically distinct from other sinonasal malignancies such as lymphoma, neuroendocrine carcinoma, mucosal melanoma, nasopharyngeal carcinoma, and olfactory neuroblastoma. Cytokeratin staining is positive while staining for leucocyte common antigen (LCA), S-100 protein, vimentin, in situ hybridization for Ebstein-Barr encoded RNA (EBER), synaptophysin and calretinin are generally negative [5]. Tumors are typically advanced at presentation with 70–100% of tumors being T4 and 10–30% of tumors having involved neck nodes [6].…”

“…Studies have shown that an aggressive multimodality approach involving combinations of surgery, chemotherapy, and/or radiation is recommended given the high likelihood of local recurrence, generally advanced stage at presentation, and proximity to critical structures [4, 5, 8]. Trimodality was evaluated by Mourad et al in single institution retrospective study of 18 patients with sinonasal undifferentiated carcinoma.…”

“…Single modality treatment (surgery or radiation alone) was associated with reduced survival compared to double modality (surgery and radiation or chemoradiation). In this specific study it was noted that trimodality was not superior to double modality [5, 8]. …”