Outcomes and ways of optimizing treatment of rotavirus infection in children with atopic dermatitis

Горелова, Е. А.; Olisova, O. Yu; Usenko, D.V.

doi:10.20953/1729-9225-2016-1-80-85

Cited by 2 publications

(1 citation statement)

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“…Кроме того, прием синбиотика снижал вдвое риск обострений атопического дерматита в период наблюдения и приводил к стабилизации и регрессу кожных проявлений аллергии через 3 месяца у большинства участников исследования. Это исследование подтвердило эффективность Нормобакта L не только в лечении ротавирусной инфекции, коррекции поствирусных нарушений микробиоты и функциональных расстройств кишечника, но и в предотвращении прогрессирования и обострений сопутствующего атопического дерматита [63].…”

Section: нормобакт Lunclassified

Probiotic Strains of Lactobacilli as Immunomodulators: Focus on Lactobacillus Rhamnosus Gg

Калюжин

2017

Medicinskij sovet

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Probiotics have long been considered not only as a way of correcting intestinal dysbiosis but also as a promising immunomodulatory solution. Over the past years, the evidence base for their effectiveness in the prevention and treatment of immuneassociated human diseases has substantially increased, the previously described mechanisms were specified and new components of the immunocorrective effect of probiotic bacteria, including those belonging to the genus Lactobacillus, have been deciphered. The meta-analytical findings and systematic reviews leave no doubt about the advisability of using certain probiotics, primarily Lactobacillus rhamnosus GG (LGG), in children for the treatment and prevention of various forms of acute diarrhea, including those associated with the administration of antibacterial agents, as well as for the prevention of respiratory infections. The results of testing the strain to be used as an adjuvant vaccine and a way of preventing atopic dermatitis are encouraging. The review analyzes the specific characteristics of present-day children who are more susceptible to allergic and infectious diseases, effector molecules of lactobacilli and signaling pathways that ensure their immunomodulatory effect, the main areas of therapeutic and preventive application and safety of probiotics, with a focus on LGG as one of the most studied and tested strains. In addition, the clinical efficacy of the synbiotic Normobakt L, a combination of LGG (4 × 109) plus fructooligosaccharides (800 mg),which has been approved in Russia for use in children with rotavirus infection against a background of atopic dermatitis, is demonstrated

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Section: нормобакт Lunclassified

Probiotic Strains of Lactobacilli as Immunomodulators: Focus on Lactobacillus Rhamnosus Gg

Калюжин

2017

Medicinskij sovet

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Experience of using synbiotics in the treatment of atopic dermatitis in children

2021

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In current conditions, traditional antiallergic therapy for atopic dermatitis does not always help to achieve timely remission, so the development of effective therapy methods is a very topical task. The promising direction of probiotics in combination with prebiot-ics, including the original mono-strain synbiotic Lactobacillus rhamnosus LGG® at optimal high concentration of 4 х 109 CFU and prebiotic fructooligosaccharides 800 mg is drawing attention. This article presents data in a clinical case format. This article presents its own data in a clinical case format. The clinical case 1 showed that administration of synbiotic in 1 sachet 1 time per day for 14 days in the composition therapeutic diet during the period of complex antiallergic therapy to a 5-month-old child with a moderate course of atopic dermatitis resulted in a pronounced positive dynamics and achievement of remission on the 10th day after the treatment start against normalization of stool. Prior to this, the child had received only antiallergic therapy, which led to improvement of the skin process, but full clinical remission could not be achieved. Clinical case 2 showed the effectiveness of synbiotic in the composition therapeutic diet during the period of comprehensive antiallergic therapy in a 10-month-old child with a mild course of atopic dermatitis. From day 2 of treatment there was a significant positive dynamics in the skin process. On day 12, remission was achieved: relief of acute inflammatory elements on the face and at the elbows on the background of increased lactobaciUus content from 104 to 106 CFU/g of feces and bifidobacteria from 107 to 109 CFU/g of feces. Clinical case 3 demonstrates the efficacy of synbiotic in 2 sachets once a day for 14 days in a 9-year-old child with atopic dermatitis of moderate severity with a continuously relapsing course. From the 4th day of the beginning of the complex therapy positive dynamics in the skin process was noted, on the 14th day partial remission was achieved: erythematous elements on the back and extremities were eliminated, signs of hyperemia, infiltration and scratching disappeared against the background of stool normalization. Signs of dryness and slight lichenification persisted. Thus, these clinical examples demonstrate a high efficacy of synbiotic treatment in the complex antiallergic therapy of atopic dermatitis in children.

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Outcomes and ways of optimizing treatment of rotavirus infection in children with atopic dermatitis

Cited by 2 publications

References 0 publications

Probiotic Strains of Lactobacilli as Immunomodulators: Focus on Lactobacillus Rhamnosus Gg

Probiotic Strains of Lactobacilli as Immunomodulators: Focus on Lactobacillus Rhamnosus Gg

Experience of using synbiotics in the treatment of atopic dermatitis in children

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