Herein, an innovative self- and pressure-adhesive biomedical
implant
was developed. Tissue adhesion was achieved with a thermosensitive
hydrogel based on poly(N-isopropylacrylamide-co-acrylamide), PNIPAAm-co-PAAm, grafted
on a substrate composed of knitted fibers of isotactic polypropylene
mesh (PP), used as surgical mesh implants. The in vitro studies, carried
out with porcine skin, showed an important role of the inclusion of
acrylamide-based comonomer (AAm) in the thermosensitive hydrogel PNIPAAm
matrix. The bonding, peeling, and shearing energies obtained for PNIPAAm-co-PAAm increased exponentially up to three, two, and six
times, respectively, compared to the gel without AAm. The physisorption
and mechanical interlocking mechanisms are responsible for such improvement
due to the simultaneous creation of hydrophobic and hydrophilic interactions
of the thermosensitive hydrogel at temperatures higher than the lower
critical solution temperature (LCST), with the porcine tissue. In
addition, our bioadhesives present excellent interfacial toughness
(∼100 J/m2) when compared to commercial bioglues
(∼50 J/m2 or lower). The results obtained represent
a very promising adhesive material that is extensible to other medical
devices that require atraumatic fixation to avoid chronic pain related
to other fixation approaches.