Outer membrane vesicles of Porphyromonas gingivalis: Novel communication tool and strategy

Okamura, Hirohiko; Hirota, Kaoru; Yoshida, Kaya; Weng, Yao; He, Yuhan; Shiotsu, Noriko; Ikegame, Mika; Uchida-Fukuhara, Yoko; Tanai, Airi; Guo, Jiajie

doi:10.1016/j.jdsr.2021.07.003

Cited by 33 publications

(35 citation statements)

References 109 publications

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“…As for specific examples, it has been described that OMVs from P. gingivalis can be internalized via receptors, such as integrin α5β1, via lipid rafts and via caveolin/clathrin-independent endocytosis (40,50,53,54,64,71). OMVs from P. gingivalis have been shown to enter cells such as human oral keratinocytes and gingival fibroblasts more efficiently than parental bacterial cells (72). Moreover, the content of T. denticola OMVs can be sensed by the absent in melanoma 2 (AIM2) inflammasome and consequently trigger an inflammatory cell death (59).…”

Section: Resultsmentioning

confidence: 99%

“…A few routes for OMV entry into host cells have been proposed: (1) endocytosis, in eukaryotic cells it can be clathrin-or caveolin-dependent, (2) pinocytosis, an actin-induced process where nonspecific uptake of extracellular components occur, (3) by lipid rafts in the host plasma membrane via caveolins or GTPases, (4) phagocytosis, and (5) by direct membrane fusion (18,22,51,53,54,56,59,(62)(63)(64)(65)70,33,(71)(72)(73)(37)(38)(39)(40)43,46,50). In that sense, OMVs have an intrinsic ability to fuse with the cell and spill their contents into the host's cytoplasm (39,46,64,72,74).…”

Section: Internalization Of Omvs By a Host Cellmentioning

confidence: 99%

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Outer membrane vesicles from commensal and pathogenic anaerobic bacteria: a systematic review of literature reviews

Castro-Vargas,

Barloy-Hubler,

Acuña-Amador

2023

Preprint

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Outer membrane vesicles (OMVs) are constitutively produced by Gram-negative bacteria (GNB), those from pathogenic bacteria play key roles in pathogen-host interactions, modulating host’s immune response and promoting virulence. OMVs of commensal bacteria are fundamental in the maturation of the host immune system and to maintain intestinal homeostasis.The objective of this systematic review was to synthesize the knowledge available on literature reviews on OMVs from anaerobic GNB. The information was classified into categories: induction and biogenesis, OMVs liberation, internalization by host cells, and their interaction. The most studied OMVs are fromPorphyromonas gingivalisandBacteroidesspp.

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Section: Resultsmentioning

confidence: 99%

Section: Internalization Of Omvs By a Host Cellmentioning

confidence: 99%

Outer membrane vesicles from commensal and pathogenic anaerobic bacteria: a systematic review of literature reviews

Castro-Vargas,

Barloy-Hubler,

Acuña-Amador

2023

Preprint

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“…P. gingivalis expresses protease activity which can be extruded with the OMVs [ 42 ]. OMVs enable bacteria and host communication as they can carry molecules involved in immune modulation [ 43 ]. P. gingivalis OMVs are adherent and small, with the ratio of cells to OMVs at approximately 1:2000 [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

How Porphyromonas gingivalis Navigate the Map: The Effect of Surface Topography on the Adhesion of Porphyromonas gingivalis on Biomaterials

Ardhani

Diana²,

Pidhatika³

2022

Materials

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The main purpose of this study is to develop an understanding of how Porphyromonas gingivalis responds to subperiosteal implant surface topography. A literature review was drawn from various electronic databases from 2000 to 2021. The two main keywords used were “Porphyromonas gingivalis” and “Surface Topography”. We excluded all reviews and or meta-analysis articles, articles not published in English, and articles with no surface characterization process or average surface roughness (Ra) value. A total of 26 selected publications were then included in this study. All research included showed the effect of topography on Porphyromonas gingivalis to various degrees. It was found that topography features such as size and shape affected Porphyromonas gingivalis adhesion to subperiosteal implant materials. In general, a smaller Ra value reduces Porphyromonas gingivalis regardless of the type of materials, with a threshold of 0.3 µm for titanium.

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“…As a result, OMVs inherited the functions of these outer membrane proteins and exhibit features such as coaggregation with other oral bacteria, invasion of host cells and pro-inflammatory potential [ 65 ]. The molecular mechanism underpinning the formation and release of P. gingivalis vesicles remains poorly defined, but different mechanisms of OMV biogenesis were proposed [ 66 , 67 ]. In the biogenesis of OMV outer membrane proteins and lipoproteins are involved in peptidoglycan cross-linking and anchorage, specifically Lpp, NlpI, OmpA (Pgm6/7) [ 68 ].…”

Section: Genetic Mechanisms Of Pathogenicity In Periodontal Bacteriamentioning

confidence: 99%

Modulatory Mechanisms of Pathogenicity in Porphyromonas gingivalis and Other Periodontal Pathobionts

Sharaf

Hijazi

2022

Microorganisms

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The pathogenesis of periodontitis depends on a sustained feedback loop where bacterial virulence factors and immune responses both contribute to inflammation and tissue degradation. Periodontitis is a multifactorial disease that is associated with a pathogenic shift in the oral microbiome. Within this shift, low-abundance Gram-negative anaerobic pathobionts transition from harmless colonisers of the subgingival environment to a virulent state that drives evasion and subversion of innate and adaptive immune responses. This, in turn, drives the progression of inflammatory disease and the destruction of tooth-supporting structures. From an evolutionary perspective, bacteria have developed this phenotypic plasticity in order to respond and adapt to environmental stimuli or external stressors. This review summarises the available knowledge of genetic, transcriptional, and post-translational mechanisms which mediate the commensal-pathogen transition of periodontal bacteria. The review will focus primarily on Porphyromonas gingivalis.

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Outer membrane vesicles of Porphyromonas gingivalis: Novel communication tool and strategy

Cited by 33 publications

References 109 publications

Outer membrane vesicles from commensal and pathogenic anaerobic bacteria: a systematic review of literature reviews

Outer membrane vesicles from commensal and pathogenic anaerobic bacteria: a systematic review of literature reviews

How Porphyromonas gingivalis Navigate the Map: The Effect of Surface Topography on the Adhesion of Porphyromonas gingivalis on Biomaterials

Modulatory Mechanisms of Pathogenicity in Porphyromonas gingivalis and Other Periodontal Pathobionts

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