Ovarian Mucinous Cystadenocarcinoma with Sarcoma-Appearing Mural Nodule of Anaplastic Carcinoma

Tsuruchi, Nobuhiro; Kaku, Tsunehisa; Kinoshita, Hideichiro; Amada, Satoshi; Saito, Toshiaki; Kamura, Toshiharu; Tsuji, Naoki; Nakano, Hitoo

doi:10.1006/gyno.1993.1204

Cited by 17 publications

(16 citation statements)

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“…Similar features were reported by Chen et al 9 and Nichols et al 11 To date, less than 30 cases of foci of anaplastic carcinoma within a mucinous carcinoma have been reported, and incidence in an adolescent is exceptional. 8,[10][11][12][13]15,16,[18][19][20][21] This case illustrates that, although rare, persistent abdominal pain in an adolescent female may represent an ovarian epithelial malignancy. The question arises as to whether to subject every adolescent with abdominal pain to a pelvic examination and/or ultrasound.…”

Section: Discussionmentioning

confidence: 98%

Anaplastic Carcinoma Arising in an Ovarian Mucinous Cystadenocarcinoma in a 17-Year-Old Female

Vella

Cracchiolo

Heller

2006

Journal of Pediatric and Adolescent Gynecology

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Section: Discussionmentioning

confidence: 98%

Anaplastic Carcinoma Arising in an Ovarian Mucinous Cystadenocarcinoma in a 17-Year-Old Female

Vella

Cracchiolo

Heller

2006

Journal of Pediatric and Adolescent Gynecology

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“…Subsequently, 16 cases have been reported in the literature. [2][3][4][6][7][8]14,15,21,24,25 Clinicopathologic data from these cases and from the 2 cases in our first series not included in this study, appear in Table 3. Eleven patients (61.5%) had stage Ia disease; 2 (11.1%) were stage Ic; 1 (5.5%) was stage II, and 4 (22.2%) were stage III.…”

Section: Discussionmentioning

confidence: 99%

“…19 That publication highlighted their unfavorable prognosis and morphology, typically that of large cells with abundant eosinophilic cytoplasm. Subsequently, about 16 additional examples have been reported in the literature, [2][3][4][6][7][8]14,15,21,24,25 most as individual cases and we included 11 examples in a prior report on ovarian mucinous tumors. 20 In this new report, we wish to highlight the relatively favorable prognosis of the tumors, when stage Ia, based on those 11 and others accrued since.…”

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confidence: 99%

Anaplastic Carcinoma in Mucinous Ovarian Tumors

Provenza

Young

Prat

2008

American Journal of Surgical Pathology

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Several types of mural nodules may develop in the wall of mucinous tumors of the ovary. The histopathologic features and prognosis of foci/nodules of anaplastic carcinoma are not well known. Although they were first thought to carry an invariably unfavorable prognosis, recent data indicate that this does not necessarily apply to stage Ia tumors. Slides from 34 consultation cases of mucinous ovarian tumors with foci/nodules of anaplastic carcinoma were reviewed and classified on the basis of their morphologic features. Cytokeratin stains were done in selected cases. Staging, treatment, and follow-up information were obtained. The foci/nodules of anaplastic carcinoma were classified histologically into 3 groups: (a) rhabdoid (n=12) having a diffuse arrangement of cells with large, bright, eosinophilic cytoplasms, eccentric nuclei, and one or more prominent nucleoli; (b) sarcomatoid (n=10) characterized by a spindle cell proliferation, with atypical and vesicular nuclei often with herringbone pattern; and (c) pleomorphic (n=12) exhibiting overlapping features of the first 2 categories. International Federation of Gynecology and Obstetrics (FIGO) stage was available in 31 cases: 15 were stage Ia, 6 stage Ic, 2 stage II, 7 stage III, and 1 stage IV. Follow-up was obtained in 21 cases. Seven patients died of the disease after a median time of 8 months: 3 stage IC, 1 stage II, 1 stage III, 1 stage IV, and the other was unstaged. Ten patients were alive and clinically free of disease after a median follow-up of 5 years: they were all stage Ia. Three patients (2 stages III and 1 stage IV) were alive with disease at 3 years, 9 months, and 7 months. The other patient (stage Ia) died of an unrelated cause. Thus, only 1 patient with stage Ia disease died, and she died of causes other than ovarian cancer. The presence of foci/nodules of anaplastic carcinoma in unruptured stage I mucinous tumors of the ovary does not necessarily carry an adverse prognosis. These foci/nodules may exhibit rhabdoid, sarcomatoid (spindle cell), or pleomorphic features.

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“…The cysts and papillae are lined by atypical epithelium that contains variable numbers of goblet cells and other intestinal cell types (24). Similarly, endometrioid tumors also express CCR9 as well as CCL25; histologically resembling adenocarcinoma of the endometrium (25). These tumors are solid masses with a soft, firm, or fibrous consistency.…”

Section: Discussionmentioning

confidence: 99%

Expression and histopathological correlation of CCR9 and CCL25 in ovarian cancer

Singh

Stockard²,

Grizzle³

et al. 2011

Int J Oncol

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Ovarian carcinoma is the most lethal gynecological malignancy among women and its poor prognosis is mainly due to metastasis. Chemokine receptor CCR9 is primarily expressed by a small subset of immune cells. The interactions between CCL25 and CCR9 have been implicated in leukocyte trafficking to the small bowel, a frequent metastatic site for ovarian cancer cells. We have previously shown that ovarian cancer cells express CCR9 and play an important role in cell migration, invasion and survival in the presence of its natural ligand in vitro. In this study, we have evaluated the expression of CCR9 and CCL25 in ovarian cancer cells and clinical samples. Ovarian cancer tissue microarrays from University of Alabama at Birmingham and AccuMax were stained for CCR9 and CCL25. Aperio ScanScope was used to acquire 80X digital images and expression analysis of CCR9 and CCL25. Flow cytometry and the Image stream system were used to conform the expression of CCR9 and CCL25 in ovarian cancer cells. Our results show significantly higher (p<0.001) expression of CCR9 and CCL25 in serous adenocarcinoma followed by serous papillary cystadenoma, endometrioid adeno-carcinoma, mucinous adenocarcinoma, cystadenoma, mucinous boderline adenocarcinoma, clear cell carcinoma, granulosa cell tumor, dysgerminoma, transitional cell carcinoma, Brenner tumor, yolk sac tumor, adenocarcinoma and fibroma cases, compared to non-neoplastic ovarian tissue. Similar to tissue expression, CCR9 was also significantly expressed by the ovarian cancer cell lines (OVCAR-3 and SK-OV-3) in comparison to normal adult ovarian epithelial cell. We provide the first evidence that CCR9 and its natural ligand CCL25 are highly expressed by ovarian cancer tissue and their expression correlates with histological subtypes. Expression of this chemokine receptor and its ligand CCL25 within primary tumor tissue further suggests a potential role of this chemokine-receptor axis in ovarian cancer progression.

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Ovarian Mucinous Cystadenocarcinoma with Sarcoma-Appearing Mural Nodule of Anaplastic Carcinoma

Cited by 17 publications

References 0 publications

Anaplastic Carcinoma Arising in an Ovarian Mucinous Cystadenocarcinoma in a 17-Year-Old Female

Anaplastic Carcinoma Arising in an Ovarian Mucinous Cystadenocarcinoma in a 17-Year-Old Female

Anaplastic Carcinoma in Mucinous Ovarian Tumors

Expression and histopathological correlation of CCR9 and CCL25 in ovarian cancer

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