Ovarian vein thrombosis as a first manifestation of COVID-19 infection

Badrawi, Noor; Abdulghaffar, Shareefa

doi:10.1016/j.radcr.2021.08.024

Cited by 6 publications

(11 citation statements)

References 6 publications

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“…Symptomatic postpartum OVT occurs in 0.01-0.05% of deliveries, especially in C-sections [17]. In this review, no significant obstetric history was found in the majority of the cases (77.77%) [6,11,13,14,[18][19][20].…”

Section: Patient Demographicsmentioning

confidence: 68%

“…Our review corroborates a similar finding. A total of 66.66% of patients presented within the first two weeks after a COVID-positive test [11,13,[18][19][20][21]. The remaining 33.33% of patients took three to eight weeks for presentation [6,14].…”

Section: Patient Demographicsmentioning

confidence: 99%

“…Fever in septic pelvic thrombophlebitis is spiking and associated with chills [12]. Abdominal pain is reported in all cases of OVT post-COVID [6,11,13,14,[18][19][20][21]. Clinical profile of the patients can be seen in Table 2.…”

Section: Clinical Profilementioning

confidence: 99%

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Ovarian Vein Thrombosis: A Sequela of COVID-Associated Coagulopathy

Patel¹,

Shah²,

Patel³

et al. 2023

Cureus

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Coronavirus disease 2019 (COVID-19) causes endothelial damage, blood stasis, and an overall state of hypercoagulability. This makes COVID a huge risk factor for venous thromboembolism (VTE) and arterial thromboembolism (ATE). Twenty percent of COVID-19 patients suffer from coagulation abnormalities like pulmonary embolism, myocardial infarction, stroke, deep vein thrombosis, etc. Ovarian vein thrombosis (OVT) has been previously linked to post-partum period, pregnancy, hypercoagulable state, or malignancy. We analyzed PubMed and Google Scholar databases for research and publications regarding OVT in patients with COVID-19. The search yielded nine case reports. These case reports were found to implicate COVIDassociated coagulopathy (CAC) as an additional risk factor for ovarian vein thrombosis (OVT). OVT most commonly presents with abdominal pain and fever, making it difficult to diagnose, owing to the similarity in presentation with multiple other pathologies. OVT can be diagnosed radiologically with ultrasound, magnetic resonance imaging (MRI) scan, or CT scan with IV contrast. CT has been used as the modality of choice for diagnosing OVT. Although rare, OVT can cause life-endangering complications by extension of thrombus into systemic veins or pulmonary artery embolization. Therefore, early diagnosis and treatment are vital. There is no official guideline for the treatment of OVT post-COVID. However, the literature supports the use of apixaban or enoxaparin/acenocoumarol.

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Section: Patient Demographicsmentioning

confidence: 68%

Section: Patient Demographicsmentioning

confidence: 99%

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Ovarian Vein Thrombosis: A Sequela of COVID-Associated Coagulopathy

Patel¹,

Shah²,

Patel³

et al. 2023

Cureus

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“…Both small and large vessel thrombosis has been reported in patients with COVID-19 [16,17]. Published reports have mentioned VSM, PV, aortic, hepatic artery, splanchnic vein, portomensenteric and ovarian vein thrombosis as a result of the hypercoagulable state due COVID-19 [2,16,[18][19][20][21][22][23][24][25][26]. The digestive manifestations of a SARS-CoV-2 infection are varied and nonspecific.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound features of abdominal thrombosis in COVID 19 patients

Dong

Qiu

Cao

et al. 2022

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Purpose: Abdominal thromboses are a poorly characterized thrombotic complication of COVID-19. The aim of this paper is to report multimodality ultrasound imaging findings of the abdomen in evaluation of thrombotic lesions in hospitalized patients with COVID-19. Patients & Methods: In this retrospective observational study, patients admitted to a single University Hospital from April 1, 2020 to April 30, 2022, who tested positive for COVID-19 and developed acute abdominal pain over the course of hospitalization were included. Abdominal ultrasound imaging studies performed in these patients were reviewed, including B mode ultrasound (BMUS), color-coded Doppler ultrasound (CCDS) and contrast enhanced ultrasound (CEUS). Thromboembolic findings on contrast enhanced computed tomography (CTA) were also recorded. Results: Finally, 13 cases of abdominal thrombosis in 226 with COVID 19 infections were included (mean age, 56.69±8.97 years; 10 men, 3 women). Thromboembolic events included: iliac thrombosis (n = 4), portal venous (PV) thrombosis (n = 3), superior mesenteric vein (VMS) thrombosis (n = 2), inferior vena cava (IVC) thrombosis (n = 5) and inferior mesenteric vein (VMI) thrombosis (n = 1). In all cases of abdominal thrombosis, during high resolution BMUS scan, intra-luminary hypoechogenic appositional thrombi could be detected. Meanwhile blood flow with reduced speed less than 20 cm/s could be observed by CCDS. High arterial flow speed was a sign of collateral flow changes with diffuse venous dilatation. On CEUS, changes of the microcirculation of the liver, spleen, kidneys or small bowel by infarctions or micro-emboli could be detected. In 3 cases of PV thrombosis and in 2 cases of IVC thrombosis, catheter interventions were successful performed for recanalization without relevant lumen reduction afterwards. In other cases, without interventional procedure, partial recanalization happened with venous flow speed over 15 cm/s and lumen reduction more than 50%. Conclusions: Our study highlights those thromboembolic complications can be seen in hospitalized patients with COVID-19. Multimodality ultrasound examinations is helpful for early and accurate diagnosis of these complications.

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“…An autopsy study by Wichmann et al reported microthrombi in the prostate of male patients [38] . In female COVID-19 patients, there were also reports of primary ovarian failure (POF) and ovarian vein thrombosis (OVT) [187] , [188] , [189] , [190] , [191] . One study reported POF due to long COVID-19 [192] , and another presented a case of OVT in a pregnant woman [193] .…”

Section: Introductionmentioning

confidence: 99%